5-MeO-DMT for longevity - Bryan Johnson

[cistanche_enjoyer]

Bryan Johnson just posted on X: “My next longevity experiment: 5-MeO-DMT.”

What is he talking about? Could there really be some health/longevity benefits from taking 5-MeO?

https://x.com/bryan_johnson/status/2031128468721905967?s=46

[bazera]

Oh this is interesting.

Imagine after his trip he drops this longevity bullshit and becomes a mystic preaching God and Love.

[Leo Gura]

It's just his clickbait. He needs to keep inventing more hi-tech BS to keep his shtick going.

Psychedelics tax your body. And 5-MeO is not to be used for such shallow purposes.

Edited 13 hours ago by Leo Gura

[Carl-Richard]

3 hours ago, Leo Gura said:

It's just his clickbait. He needs to keep inventing more hi-tech BS to keep his shtick going.

Psychedelics tax your body. And 5-MeO is not to be used for such shallow purposes.

Working out taxes the body as well. You're not supposed to workout 24/7.

[r0ckyreed]

27 minutes ago, Carl-Richard said:

Working out taxes the body as well. You're not supposed to workout 24/7.

Not a good comparison. Yes working out taxes the body but the muscles grow. Psychedelics tax your body differently, leading to long-term consequences. Your brain cells don’t grow back like your muscles do. Neurogenesis doesn’t work like you’d think. Maybe you can’t work out 24/7, but you can workout maybe 12/7 by working different muscle groups. Even walking and wall-sitting is a workout. Psychedelics should be done seriously for one purpose—Awakening.

[cistanche_enjoyer]

I was thinking more in terms of kundalini/prana energy. Maybe 5meo can dissolve some energetic blockages, for example by getting at such high levels of consciousness, you could get new perspectives on your life and resolve traumas, unconscious stress, etc.

This would then ultimately benefit health and longevity.

I have never tried 5meo though so I don’t know how it would be different from other psychedelics in this context.

[Vynce]

Bro is bored already. Only 100 more years to go. 

[Carl-Richard]

2 hours ago, r0ckyreed said:

Psychedelics tax your body differently, leading to long-term consequences.

In what way? What makes it detrimental to longevity?

 

2 hours ago, r0ckyreed said:

Your brain cells don’t grow back like your muscles do. Neurogenesis doesn’t work like you’d think.

Taxing the brain now? Why is it detrimental to longevity? How do you know this?

Edited 6 hours ago by Carl-Richard

[Oppositionless]

Idk about longevity but following 5 meo I began my kriya yoga practice and had a kundalini awakening which led to a monthlong period of pretty intense destabilization.

If you believe in chakras you might say 5 meo forcibly opens the crown chakra.

Edited 4 hours ago by Oppositionless

[Davino]

If you do it enough you may become immortal 

I'm interested to see if he has an ego death, how he'll deal with it. All his life working towards elongating the unchangeable impermanence of the body and then 5-MeO-DMT pushing him to confront death.

I have to say I find value in his content. Usually Leo is too harsh on him for my taste, although it may be my bias to favour him as well.

[Purple Man]

There is a Woody Allen phrase in one of his movies that I think sums it all up. He was (again) certain that he had a terminal illness, only to discover he was totally healthy. So he runs in the streets jumping for joy, shouting "I am not goint to die! I am not going to die!"...and then he stops, gets sad again and says something like "I am not going to die...today..."

And this man, while very eccentric and surrounded by unusual means, is only showing a very common human fear of death, to which he first tried to response with a brute approach, prolonging that which he identifies with nowadays, his body. And maybe he´s already entered the previously commented Woody Allen´s character phase: "so what if I reach170 years of age? I will dissapear then". He´s probably seen how futile this effort is, so next step for him is to look for Eternity in a more subtle way. He must have heard amazing stories involving 5 MeO-DMT and he´ll take that route.

Edited 1 hour ago by Purple Man

[FckdProgress]

Bryan went ahead and gave some justification for his earlier claim, as well as an image referencing some papers.

I'd be interested in seeing what more knowledgable peers (in both the experiential psychonautic context and the relevant scientific literature.. and maybe the neuroscience and CogSci angles) would discuss regarding it.

Here it is:

Quote

I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about.

+ Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models.

+ Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level.

+ Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness.

+ Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.

 

Source: https://x.com/bryan_johnson/status/2031420064092848490?s=20

 

[Leo Gura]

I don't know that he so much fears death as he literally has nothing better to do. He needs to feel like he's doing something important and revolutionary, something historic, like he is some kind of pioneering genius. That's the ego trip.

It gives him a sense of life purpose. So he is grasping at straws to pioneer stuff.

Edited 45 minutes ago by Leo Gura

[Cireeric]

But I honestly believe or intuit that there might be something to the relation of psychedelics and longevity or health. The psychedelic-experience definitely feels very much like a whole system reset and I would argue this is not limited to phenomenology, but also has some physiologic correlation, some of which already backed up by data. I think its an cool experiment to investigate this more thoroughly. The field of longevity expands through people like Bryan.

Edited 15 minutes ago by Cireeric

[cistanche_enjoyer]

43 minutes ago, FckdProgress said:

+ Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models.

Damn that’s interesting. Looking forward to seeing his data and health markers afterwards

[OBEler]

4 hours ago, Oppositionless said:

Idk about longevity but following 5 meo I began my kriya yoga practice and had a kundalini awakening which led to a monthlong period of pretty intense destabilization.

If you believe in chakras you might say 5 meo forcibly opens the crown chakra.

After your kundalini awakening what state are you now in? Do you regret your kundalini awakening?

[Oeaohoo]

He will become God and live forever!