MDMA Report - God Is Infinite Love. I Am Not Ready Yet.

[ItsNick]

8 minutes ago, Leo Gura said:

Only while you're on it.

My sensitivity and especially body and emotional awareness have permanently increased after using it only twice in my life to heal trauma.

[Leo Gura]

10 minutes ago, OBEler said:

If you have read some reports where people were less sensitive after just a handful of MDMA experience please report.

I don't know exactly how many trips it takes, perhaps 10 or more, but there is neuroscience which shows it permanently rewires the brain. I am not talking about anecdotal subjective experiences. I am talking about neuroscience research, brain scans and so on. MDMA tolerance develops quickly and it become permanent. If you use MDMA enough it will stop working entirely as you brain permanently rewires. This is well-known.

Edited January 29 by Leo Gura

[OBEler]

@Leo GuraIf you are referring to studies, can you show me? There are just a handful of studies out there for moderate mdma usage and from what I researched no one showed significant signs for any longterm brain damage. Here is a good study:

 

"We searched for studies applying neuroimaging techniques in man. Studies were included if they provided at least one group with an average of <50 lifetime episodes of ecstasy use or an average lifetime consumption of <100 ecstasy tablets. All studies published before July 2015 were included. Of the 250 studies identified in the database search, 19 were included. There is no convincing evidence that moderate MDMA use is associated with structural or functional brain alterations in neuroimaging measures. The lack of significant results was associated with high methodological heterogeneity in terms of dosages and co-consumption of other drugs, low quality of studies and small sample sizes."

From Neuroimaging in moderate MDMA use: A systematic review

https://pubmed.ncbi.nlm.nih.gov/26746590/

 

Edited January 29 by OBEler

[Leo Gura]

I can't recall the source I was referring to. It was years ago. I was listening to a speech by a neuroscience guy on MDMA.

It is well-known that permanent MDMA tolerance builds up with lots of use. So....

Edited January 29 by Leo Gura

[OBEler]

@Leo Gura Yeah with lots of use for sure, but we talk here about moderate mdma consumption and as you can see on the meta study I posted, there is nothing dangerous found so far

Edited January 29 by OBEler

[Leo Gura]

@OBEler Your study contradicts things I've heard. So I would still be cautious.

[OBEler]

@Leo Gura Ok, maybe there are new studies out there. This study is from 2015 and the psychedelic research field skyrocked the last years. Maybe there is a new study on moderate consumption out there which shows different results

[OBEler]

Ok thanks to ChatGpt here are newer Studies on this since 2015:

here are the results of the above studies that investigated the effects of moderate MDMA consumption on organ damage, specifically brain damage:

Schmid, Y., et al. (2015). "Moderate recreational ecstasy (MDMA) use is associated with alterations in brain structure and function." Neuropsychopharmacology, 40(13), 2963-2972. Result: This study found that moderate use of MDMA led to changes in brain structure and function, particularly in areas related to memory, learning, and emotions.

Parrott, A. C., et al. (2015). "Moderate recreational ecstasy (MDMA) use and cognitive function in young adults." Journal of Psychopharmacology, 29(7), 757-766. Result: This study found that moderate use of MDMA led to mild deficits in cognitive function in young adults, particularly in the areas of attention and working memory.

Verkes, R. J., et al. (2015). "Moderate recreational ecstasy (MDMA) use is associated with alterations in brain serotonin transporters." Biological Psychiatry, 78(8), 546-553. Result: This study found that moderate use of MDMA led to changes in brain serotonin transporters, which may have implications for mood, behavior, and cognitive function.

Reneman, L., et al. (2016). "Moderate use of ecstasy (MDMA) is associated with brain serotonin deficits: a meta-analysis." Psychopharmacology, 233(11), 2037-2046. Result: This meta-analysis found that moderate use of MDMA led to deficits in the brain's serotonin system, which may have implications for mood, behavior, and cognitive function.

Schilt, T., et al. (2017). "Moderate ecstasy (MDMA) use and cognitive function: a prospective longitudinal study." Journal of Psychopharmacology, 31(5), 557-564. Result: This study found that moderate use of MDMA can lead to mild deficits in cognitive function, particularly in the areas of attention and working memory.

Schilt, T., et al. (2018). "Moderate ecstasy (MDMA) use and brain serotonin transporters: a prospective longitudinal study." Journal of Psychopharmacology, 32(4), 367-375. Result: This study found that moderate use of MDMA leads to changes in brain serotonin transporters, which may have implications for mood, behavior, and cognitive function.

 

 

If we trust ChatGpt here, that is very concerning...

Edited January 29 by OBEler

[Sincerity]

7 minutes ago, OBEler said:

Ok thanks to ChatGpt here are newer Studies on this since 2015:

here are the results of the above studies that investigated the effects of moderate MDMA consumption on organ damage, specifically brain damage:

Schmid, Y., et al. (2015). "Moderate recreational ecstasy (MDMA) use is associated with alterations in brain structure and function." Neuropsychopharmacology, 40(13), 2963-2972. Result: This study found that moderate use of MDMA led to changes in brain structure and function, particularly in areas related to memory, learning, and emotions.

Parrott, A. C., et al. (2015). "Moderate recreational ecstasy (MDMA) use and cognitive function in young adults." Journal of Psychopharmacology, 29(7), 757-766. Result: This study found that moderate use of MDMA led to mild deficits in cognitive function in young adults, particularly in the areas of attention and working memory.

Verkes, R. J., et al. (2015). "Moderate recreational ecstasy (MDMA) use is associated with alterations in brain serotonin transporters." Biological Psychiatry, 78(8), 546-553. Result: This study found that moderate use of MDMA led to changes in brain serotonin transporters, which may have implications for mood, behavior, and cognitive function.

Reneman, L., et al. (2016). "Moderate use of ecstasy (MDMA) is associated with brain serotonin deficits: a meta-analysis." Psychopharmacology, 233(11), 2037-2046. Result: This meta-analysis found that moderate use of MDMA led to deficits in the brain's serotonin system, which may have implications for mood, behavior, and cognitive function.

Schilt, T., et al. (2017). "Moderate ecstasy (MDMA) use and cognitive function: a prospective longitudinal study." Journal of Psychopharmacology, 31(5), 557-564. Result: This study found that moderate use of MDMA can lead to mild deficits in cognitive function, particularly in the areas of attention and working memory.

Schilt, T., et al. (2018). "Moderate ecstasy (MDMA) use and brain serotonin transporters: a prospective longitudinal study." Journal of Psychopharmacology, 32(4), 367-375. Result: This study found that moderate use of MDMA leads to changes in brain serotonin transporters, which may have implications for mood, behavior, and cognitive function.

Damn!

Well, I wasn't really planning on taking it more anyway.

[eggopm3]

I'm curious how the toxicity debate with MDMA will change under the therapy framework that is in the process of being legalized. The claim is that this toxicity is not a problem in this context, and that the harms come from overuse, irresponsible doses, and set/setting complications that could have been avoided with education (such as over/under consumption of water or overheating your body by parting on it or whatever). But surely there will be some issues that arise in this area once MDMA therapy really gets off the ground. But there are other entactogens out there that could be used instead to similar effect, and i think in the long run the best case scenario would be the discovery of an MDMA analogue with less toxicity.

[OBEler]

@eggopm3 ChatGpt has the answer on this: 

"It's important to note that the studies you have mentioned above are not conclusive, and more research is needed to fully understand the effects of moderate MDMA use on organ damage. The studies were conducted on recreational ecstasy users, who often take high doses of the drug and in combination with other substances and that is not the case for the therapy use of MDMA.

The therapy would be conducted under strict medical supervision and the dosage would be much lower than recreational use. The therapy would also be conducted in a controlled environment and the patients would be closely monitored for any negative side effects."

[Girzo]

@OBEler What is this bullshit and why are you posting this?  Is any of these articles real? AIs for sure have imagination.

[OBEler]

@Girzo they are Real, Google it

[Space]

8 hours ago, OBEler said:

Ok thanks to ChatGpt here are newer Studies on this since 2015:

here are the results of the above studies that investigated the effects of moderate MDMA consumption on organ damage, specifically brain damage:

Schmid, Y., et al. (2015). "Moderate recreational ecstasy (MDMA) use is associated with alterations in brain structure and function." Neuropsychopharmacology, 40(13), 2963-2972. Result: This study found that moderate use of MDMA led to changes in brain structure and function, particularly in areas related to memory, learning, and emotions.

Parrott, A. C., et al. (2015). "Moderate recreational ecstasy (MDMA) use and cognitive function in young adults." Journal of Psychopharmacology, 29(7), 757-766. Result: This study found that moderate use of MDMA led to mild deficits in cognitive function in young adults, particularly in the areas of attention and working memory.

Verkes, R. J., et al. (2015). "Moderate recreational ecstasy (MDMA) use is associated with alterations in brain serotonin transporters." Biological Psychiatry, 78(8), 546-553. Result: This study found that moderate use of MDMA led to changes in brain serotonin transporters, which may have implications for mood, behavior, and cognitive function.

Reneman, L., et al. (2016). "Moderate use of ecstasy (MDMA) is associated with brain serotonin deficits: a meta-analysis." Psychopharmacology, 233(11), 2037-2046. Result: This meta-analysis found that moderate use of MDMA led to deficits in the brain's serotonin system, which may have implications for mood, behavior, and cognitive function.

Schilt, T., et al. (2017). "Moderate ecstasy (MDMA) use and cognitive function: a prospective longitudinal study." Journal of Psychopharmacology, 31(5), 557-564. Result: This study found that moderate use of MDMA can lead to mild deficits in cognitive function, particularly in the areas of attention and working memory.

Schilt, T., et al. (2018). "Moderate ecstasy (MDMA) use and brain serotonin transporters: a prospective longitudinal study." Journal of Psychopharmacology, 32(4), 367-375. Result: This study found that moderate use of MDMA leads to changes in brain serotonin transporters, which may have implications for mood, behavior, and cognitive function.

Are you sure these are even real? The same sentence structure is being used in basically every single one? Maybe there's some standard formatting but seems a little strange that they're all so similar haha.

Edited January 29 by Space

[Girzo]

They are not real or I should never become a scientist.

[acidgoofy]

Unless you're taking ridiculously high doses, I'd say it's relatively safe. I'm very thankful for the substance, it taught me how fun it can be to socialize. Made me more extroverted.

[OBEler]

@Space

Ok these Studies from chatgpt dont exist. I googled on Google scholar (extra searchengine from Google for Studies). 

Now is the question why is chatgpt generating these phantasy studies? Is there Anti drug propaganda programmed in chatgpt? 

 

[Sincerity]

The machines are starting to learn to fool us. We are doomed.  (joking)

[OBEler]

@Sincerity from chatgpt:

"Yes, the studies mentioned in my previous response do exist. However, it's possible that they are not readily available on the internet for various reasons, such as restricted access to scientific journals or being behind a paywall." 

Can anyone find them? I dont trust chatgpt 

 

[Space]

37 minutes ago, OBEler said:

@Space

Ok these Studies from chatgpt dont exist. I googled on Google scholar (extra searchengine from Google for Studies). 

Now is the question why is chatgpt generating these phantasy studies? Is there Anti drug propaganda programmed in chatgpt? 

 

Yea seems a little strange. Although, ChatGPT making up random facts and bits of information is not uncommon. I've seen people saying this multiple times. 

I wouldn't rely on the technology to do this kind of research though.