Anybody have experience with magnesium glycinate?

[Carl-Richard]

I tried it today and I've never been this knocked out before in terms of low energy and weird hyper-serotonergic state. "Normal" magnesium (oxide and citrate) doesn't do this to me. Could it be the glycine? I took 360 mg (pure mineral weight), which adds up to over 2g of glycine. I was debating whether to only take 240mg because the improved absorption makes it roughly equal to the 350mg of oxide and citrate I was taking. So maybe it's also excess magnesium, but again, this does not feel the same as just magnesium. I'm asking because it wasn't the only new thing I took (I also had more E vitamin than usual and a different fish oil supplement), but it feels like it could be the culprit.

Edited October 10 by Carl-Richard

[Leo Gura]

I've tried all sorts of magnesiums, never felt any one of them.

[Beans]

I’ve been taking magnesium glistenate for the past two days. 
I usually have extreme anxiety. Often times making me extremely dehydrated. And overall stressed. 

It could be placebo or it’s actually helping.

Though I would say usually without medication my anxiety is normally 9-10 

with the magnesium it feels more like 

6-7 sometimes even 5 with my medical cannabis and matcha.

Overall I feel better. 
 

calmer and more relaxed. Instead of feeling on edge as i I would usually feel. 
 

I feel a bit more free.

[Carl-Richard]

@Beans

I'm so relaxed I could sing an opera naked.

But my mind is also like a snail in a pool of glue.

Edited October 10 by Carl-Richard

[MsNobody]

Yes first time I took I was sleeping so well and woking up super rested!! Now its part of my sleep stack, Magnesium Theanine L-Threonate Apigenin + Glycine + Mag Glycinate, I dont wake up at night anymore and if I wake up I go to back to sleep easily. My sleep game has totally changed after that, I started supplementing because my Oura ring was showing interruptions in my sleep. 

That being said I take little, if I take two pills of Glycine which equals 1g the next day I wake up feeling groggy and super slow, my eyes dont really want to open, so taking 2g would probably be terrible. Makes sense you feel this way

Edited October 10 by MsNobody

[Mannyb]

Most supplements labeled “300 mg of magnesium” actually provide only about 15–20% of that as real, absorbable elemental magnesium.
Now that I’m taking the correct dosage with a 3500 mg magnesium citrate supplement — which is effectively around 500–700 mg of true magnesium — I can really feel its effects and whenever I need even better rest and bowel movements, I bump it up to as much as 10,000 mg.

Even at 10,000 mg of magnesium citrate, it’s still safe because that equals roughly 1,500–2,000 mg of elemental magnesium, which the body easily excretes through the bowels, making it self-limiting rather than toxic.

Although the top 3 essential practices are all included in yoga which are Deep breathing, Stretching or yoga, Meditation.

It’s amazing how the ancient yogis intuitively understood what modern science is only now confirming: that breath, movement, stillness, sunlight, and alignment of mind and body are the true foundations of health, rest, and vitality. 

 

Edited October 10 by Mannyb

[yetineti]

I use this magnesium. I am about 150lbs. I take 100mg in the morning and 100mg at night or just 200mg at night.

Any more and I think I’d pass out and shit myself.

[Beans]

13 hours ago, Carl-Richard said:

@Beans

I'm so relaxed I could sing an opera naked.

But my mind is also like a snail in a pool of glue.

Lol, you are funny 

That actually made me laugh out loud. 

Righteous (meaning badass) 

[Carl-Richard]

5 hours ago, MsNobody said:

That being said I take little, if I take two pills of Glycine which equals 1g the next day I wake up feeling groggy and super slow, my eyes dont really want to open, so taking 2g would probably be terrible. Makes sense you feel this way

It's the closest thing I've come to a sedative-anti-psychotic like Rivotril (Klonopin, clonazepam), just even more depressive and soul-draining. Your brain is literally stopped dead in its tracks. Glycine is a weird substance. It has its own receptor in the brain and is mostly inhibitory. People who take 10-20g of this shit must end up in a K-hole (if they hadn't built up tolerance to it).

Edited October 10 by Carl-Richard

[daydrinking]

On 10.10.2025 at 3:06 AM, Leo Gura said:

I've tried all sorts of magnesiums, never felt any one of them.

basically feel the same. i'm taking a magnesium complex with citrate, oxide, glycinate and malate. been taking it for over a year now and it's just part of my routine.

[Carl-Richard]

9 hours ago, daydrinking said:

basically feel the same. i'm taking a magnesium complex with citrate, oxide, glycinate and malate. been taking it for over a year now and it's just part of my routine.

How much glycine do you get from one serving?

[Carl-Richard]

Yesterday, I switched the magnesium back to the oxide/citrate form and dropped the vitamin E supplement, felt better, and today I added back the vitamin E, and I think it might be the vitamin E dear god. It's understandable as I'm taking around 300% of RDI, but why they make the supplements so strong 😩?

Edited October 11 by Carl-Richard

[Carl-Richard]

Tried the magnesium glycinate again, and while it doesn't have the soul eviscerating effects of vitamin Evil, it makes me want to fall asleep (at the gym). Maybe the dose is too high (now 240 mg pure mineral weight) and there are some possible confounds, but man I can't remember ever having wanted to take a nap when warming up for deadlifts. Anyways, next I'll be trying magnesium malate.

Edited Wednesday at 08:41 PM by Carl-Richard

[Norbert Somogyi]

I’ve been taking magnesium bisglycinate, and I sometimes experienced this tired or drowsy feeling. It's not as expressed for me, unless I take a very high dose (1000mg+).

Glycin, which this form of Magnesium is paired with, has a calming effect. That would explain it.

Nowadays I take 600-800mg a day, but it's needed for my high dosage of vitamin D otherwise I develop insomnia and other uncomfortable symptoms over time.

Malate sounds like a good alternative, taurate or even threonate if you can afford it (supposedly even more bio-available, especially since it can evidently cross the blood-brain-barrier).

[Human Mint]

I do, I am currently taking a supplement that combines 5 different magnesium sources, but not as powerful as just magnesium glycinate. I take it 2-3 hours before bed.

[daydrinking]

On 11.10.2025 at 11:50 PM, Carl-Richard said:

How much glycine do you get from one serving?

its 350mg, and i take one capsule in the morning on an empty stomach and one before sleep.

[Spiral]

Magnesium and vitamin B prevent hangover entirely for me. It should be taken before you drink. You'll still be tried however.

[Carl-Richard]

On 16.10.2025 at 5:03 PM, Norbert Somogyi said:

I’ve been taking magnesium bisglycinate, and I sometimes experienced this tired or drowsy feeling. It's not as expressed for me, unless I take a very high dose (1000mg+).

Glycin, which this form of Magnesium is paired with, has a calming effect. That would explain it.

Nowadays I take 600-800mg a day, but it's needed for my high dosage of vitamin D otherwise I develop insomnia and other uncomfortable symptoms over time.

I don't know about you but I have a very high bar for using one substance to mask the side effects of another substance. There are probably some underlying issues you're trying to mask with the first substance that you should be trying to solve, if it's not some unsolveable chronic health issue. Especially with essential nutrients like vitamin D, the goal is ideally to ensure optimal functioning, not masking pathology.

Edited 1 hour ago by Carl-Richard