What Am I

Yep, psychedelics are incredible. Sounds like you had a really nice intro. Be careful pushing the dose higher though. As amazing as they can be, a bad trip can be equally powerful and horrific in the opposite direction. The joy that surpasses all understanding which you're expecting could become the terror that surpasses all understanding.

Reminds me of this awesome scene in Doctor Strange.

Linking to another thread where I talked about harmalas, including where to get them. Feel free to ask any additional questions, as I have a decent amount of experience using harmalas. EDIT: I just checked and it would appear the harmalas I linked in the thread are out of stock. Here's some alternatives. Harmine - https://www.harmalas.com/products/harmine-hydrochloride THH - https://www.harmalas.com/products/tetrahydroharmine-thh-freebase

It is interesting. I wonder if it has something to do with the way 5meo has a crazy affinity to 5-HT1A receptors. It really is unique. I'm thinking even 1mg or 0.5mg 5meo per 20mg of DMT. Thankfully that'd be very easy to do with the volumetric dosing inherent to IM/subq injecting.

Right, I've read similar in all my searching, and I can attest to it in my own limited experience. I wonder what would happen if you increased the ratio in favor of DMT though. Maybe there's a point where the experience would 'click' into something more interesting. Here's a trip report from Erowid that caught my attention. This person used a similar ratio to my own, which is a little confusing considering the content of the report. The experience they describe is closer to what I have in mind as a kind of special experience produced by the two substances. https://www.erowid.org/experiences/exp.php?ID=116663

A year or so ago, I tried ~300mg of the substance that the church provides. In my opinion, it did feel different from mushrooms. But it also felt different from 5meo. Assuming it's legitimately a novel molecule (4-HO-5-MeO-DMT), I guess it'd make sense if it felt significantly different from either. It was also much stronger than what you'd expect from 300mg. I'm not insensitive to the skeptical side of the debate either though. I resonate with fellas like @Girzo in his observance of the ridiculous/unprofessional actions of the people involved. And I recognize my subjective experience could be tainted by my own unconscious bias. It'd be nice if we didn't have this uncertainty and could know definitively one way or the other, because the synthesis of psilomethoxin via mushrooms would be really cool and interesting all on its own. It could potentially lead to breakthroughs in novel psychedelic creation.

Anyone have experience combining DMT and 5-MeO-DMT? It seems to me that this combo could have some serious potential for putting someone in a rarefied state. They're both endogenous psychedelics whose natural release are likely involved in advanced states of meditation. I guess the question would be whether they're released in a particular ratio to produce a particular effect. Or perhaps it's all more complicated than I'm imagining. I do have a small amount of personal experience with the combo in a 1:4 ratio with DMT being the higher. The ROA was subcutaneous injection. It's been a while, but if I remember correctly it was ~5mg/20mg, which was a pretty strong experience indeed. I get the feeling the 5meo was overpowering the DMT though, and it mostly became a 5meo trip with slight DMT visuals while lacking the DMT headspace. Whereas 20mg of DMT on its own would produce more of the DMT effects. Would love to hear if anyone else has experimented.

This turned out to be so accurate. I took a low dose (10mg) of 4-HO-MET, a psych well known for being easy and gentle, and experienced a pretty significant trip. Just like with DMT or mushrooms, my subconscious was laid bare and my usual sense of self became profoundly expanded. Strong euphoria bordering on bliss was passing through my body. It's so cool because you can feel the sensation originating from some kind of higher plane. Was an awesome trip overall, just stronger and way more profound than expected. I have no idea how kids take this stuff and hang out socially lol. Though I wonder if the energetic transformations that people like us in this forum have experienced via 5meo and spiritual practice would have a strong influence on psychedelic trips. It seems pretty likely imo.

I wanted to share this awesome older video of Adyashanti and Loch Kelly describing their everyday state of consciousness after extensive spiritual practice and transformation has occurred. I feel like this type of description is not easy to find for whatever reason. It has lined up very well with a bunch of experiences I've had using 5-MeO-DMT, and even bits of my sober experience get the occasional taste of the picture they paint. It's really valuable imo to hear what a matured version of conscious awakening would be like. It sounds liberating indeed.

It's indeed the essential question which we'd probably all like to know the answer. Thanks, happy to be here where I can discuss these things. God knows I don't have many other outlets to do it.

Don't ask me

Awesome post, it seems to me it's always helpful to call out the need for balance in a spiritual approach. I've come to interpret effective spiritual practice as kind of like riding a bike, where the act itself is a flow of instinctual skill that gets uncovered more and more as the practitioner exposes themself to what is, the Self, etc. So a heavy emphasis on direct experience and mostly non-conceptual. On the other hand, there's probably a large amount that can be said intellectually about the spiritual process, just as there's mathematics and physics that could explain how a person doesn't tip over while riding a bike. And it seems to me the intellectual side would especially have its place in spirituality in the form of useful pointers and maps of the experiential territory. Though I can't claim to have any significant skill, so I could be off on the interpretation. Very interesting, I was not aware of this. Perhaps I've unknowingly fallen into this category as well considering my experiential bias.

I realized this thread, acting as a warning based on firsthand experience, could also benefit from a scientific description of the dangers. See below for an excerpt from the FIVE GUIDE, which I linked a few posts ago. 5-MeO-DMT and Serotonin Toxicity Serotonin Toxicity is best understood as a type of poisoning or adverse effect of serotonergic drugs involving excessive intrasynaptic serotonin that results in toxic levels of signaling via the 5HT2A receptor [29]. It is often discussed as Serotonin Syndrome which is less accurate as it’s not a group of symptoms that define a condition and it can occur along a spectrum . Therefore, substances that increase intrasynaptic serotonin such as monoamine oxidase inhibitors (e.g., MAOIs), serotonin reuptake inhibitors (SRIs e.g., SSRIs, SNRIs) as well as serotonin releasing agents (SRAs e.g., MDMA) are most implicated in the development of Serotonin Toxicity [30]. However, the underlying mechanisms of each substance and their abilities to act additively, synergistically, or diminutively in combination require evaluation to understand if the combination is truly high risk for Serotonin Toxicity [9]. Relative to other tryptamine psychedelics, 5-MeO-DMT appears to be a stronger serotonin stimulating substance and may even be able to activate 5HT receptors to a greater extent that serotonin itself, whereas classic tryptamines (LSD, psilocybin, DMT) are only partially able to stimulate serotonin receptors [4, 25]. It is also a full agonist at the 5HT1A receptor. This may explain why it appears Serotonin Toxicity can occur with 5-MeO-DMT (particularly in combination with MAOIs) whereas it has not been reported with LSD, psilocybin, or DMT. Other contributing aspects of 5-MeO-DMT’s pharmacology to risk of Serotonin Toxicity could include its serotonin reuptake inhibition as well as the presence of its active metabolite bufotenine (more probable with toad venom).

True enough, I bet a highly advanced individual fully established as the Self may have a less disjointed experience.

If I were to guess based on a large number of experiences with it, I'd say DMT facilitates an opening via the third eye into a hyperdimensional reality that's in some way related to an afterlife state for humans. That's the intuition I've had in quite a few trips. A more honest answer would be that I simply don't know for sure though lol. One warning I could give if you ever decide to try it is that the DMT experience is probably not what you're expecting. I remember imagining it'd be angels and heavenly realms like in renaissance artwork, but it's more like incomprehensible geometry and mental profundity beyond what someone could make up. The experience is so transcendent, you can only really bring back the memories of your reaction to it rather than memories of the event itself. It's just too different from our normal mode of operation.