Your Microbiome Is Very Important When It Comes To The Immune System

[The Don]

Hi.

I recently found this video on YouTube, a video related to the importance of your microbiome in immune system functioning.

If you have health problems, the first thing you should do is restore your microbiome; to make it powerful again. If you don't know what the microbiome is, read this. A short description of the microbiome would mean a system made of healthy gut bacteria that helps your body, including your immune system.

If you want to have a healthy microbiome, you need to eat only healthy foods. You should give up on refined carbohydrates, including bread, pasta, rice, potatoes, and sugars. You should eat more healthy fats like butter. I'm specifically saying butter because it contains butyrate, a short-chain fatty acid that provides fuel for the cells of our gut lining, supports immune system functions of the colon wall and protects against certain diseases of the digestive tract.

I can guarantee that people who give up unhealthy foods will feel a lot better. When it comes to food we should know that food is medicine.

Here's a quote by Hippocrates: “Let food be thy medicine and medicine be thy food.”

Another one by Hippocrates: "If you want to heal somebody, ask him if he's willing to give up the things that brought him in this situation."

A healthy lifestyle is necessary.

[The Don]

17 hours ago, Michael569 said:

Not sure if I would classify butter as "healthy fat".

Humans need more fat.

Your brain is made of 60% fat.

The human mammal milk contains over 50% fat.

Please, read more about the ketogenic diet.

It can change your life for the better. And not only your life but your health too; in a positive way.

Edited April 22, 2020 by The Don

[TrynaBeTurquoise]

1 hour ago, The Don said:

Humans need more fat.

Your made is made of 60% fat.

The human mammal milk contains over 50% fat.

Please, read more about the ketogenic diet.

It can change your life for the better. And not only your life but your health too; in a positive way.

I don't think he is slamming fat itself but the fact there are better fat sources than butter. I don't think butter is bad (especially if you have a high metabolism) but you can upgrade the nutritional quality by replacing it with organic ghee. 

[Rigel]

1 hour ago, The Don said:

Please, read more about the ketogenic diet.

For some people it's great. For some it isn't. For some it's great for some time and then it isn't.

There's no one size fit for all. Yes read the scientifique literature but more importantly listen to your body. What does it want right now? Does it want to fast. Does it want a salad, a mango, or big grass fed steak?

The biggest concern that I have is not about which food is right or wrong but what is the quality of said food. Some vegans here will think that meat isn't healthy but there's a big difference between commercially raised and wild animal that you go hunt yourself. Same for the way veggies are grown, etc.

Edited April 21, 2020 by Rigel

[LfcCharlie4]

@Michael569  Brilliantly said!

[montecristo]

On 4/22/2020 at 5:17 PM, Michael569 said:

 

I am not bashing on ketogenic diet. It can be the only way for people with epilepsy and schizophrenia but an unmanaged ketogenic diet is a cardiovascular disaster. I've seen keto followers eat gigantic chunks of butter claiming they are doing a healthy thing. Stripping  human diet of fruits, legumes and most vegetables and calling is healthy is a very peculiar thing. 

@Michael569when it comes to heart disease saturated fat intake is mostly irrelevant. It's baseline inflammation and endothelial damage that's the problem, cholesterol comes to the site of the damage to heal things. If you were an alien in a spaceship studying car crashes and always saw ambulances and police cars wherever there were car crashes you might think ambulances and police cars caused car crashes but oh how wrong you'd be.

The humans who exist today evolved in a situation with very little fruit and vegetable material in our diets, every plant food you see in the grocery store has been bred into existence in recent history since the last ice age, which was the most significant selective pressure on our species. So to say that stripping the diet of these foods is peculiar, is peculiar. What's really peculiar is to eat them.

[montecristo]

i think the confusion centers around the fact that low fat plant based diets successfully reverse insulin resistance and so do high fat low carb ketogenic diets.

The problem is consuming too much energy in the form of simultaneous intake of fats and carbs. This causes fat cells to become insulin resistant and to signal the rest of the body to do so as well.

The key difference between the two approaches is that plant based diets are not nutritionally complete in teh long term. They dont contain adequate, vitamins A, D, K2 or b12 nevermind an optimal ratio of amino acids or fatty acids. They also tend to be antigenic and drive inflammation due to various irritant compounds found in plant foods.

People go vegan and heal their insulin resistance in much the same way they would if they were fasting, but you cant starve yourself forever and expect to be healthy.

[montecristo]

@Michael569

antigenic substances in plants arent irrelevant, and no Dr. Gundry isnt the only one who is raising this issue, there are countless respected researchers saying the same look up Nora Gedgaudes for example. Are you denying the existence of oxalates, salicylates, lectins etc and the connection with LPS?

Beta carotene content is irrelevant if your like the many people with certain gene polymorphisms that can't do squat with beta carotene, in those cases it's just another thing to process and eliminate. 

TBH vitamin D isnt the most relevant to my point bc you can get it from the sun true, but it's importance cannot be overstated, likely why we have that built in redunddancy to get it from food or sun. But in a northern latitude it would have been necessary to get adequate amounts from animal foods. especially since we would have been clothed to keep warm. Again in the skins of animals lol.

Isn't it odd that all humans absolutly NEED b12 to avoid permanent brain damage and we dont NEED any of the phytochemicals, antioxidants polyphenols found in plants to be totally healthy and survive generationally? Like at all...

 What's really not debatable is the non-necessity of plants and the necessity of meat in a context where supplements arent available. We didnt evolve to need supplements did we?

Practically all studies showing benefits from plant compounds are isolating a few variables, noticing certain narrow metrics improving and ignoring potential side affects. Exactly like all drugs and medicines. It doesnt make sense that the human organism would require any of these random xenohormetic compounds.

It's certainly true that some human genetic phenotypes might make those nutrient conversions quite well and have very robust diverse microbiomes, these are the people who seem to be fine with vegan diets but this is the exception. What i believe to be the case is that most people's microbiomes have been decimated given antibiotics glyphosate oversanitation and also dont have the genetic capacity to derive significant nutrition from plant foods, if these individuals try to be vegan it will obviously not work out well for them.

it's not so much that meat cures enzymatic or gut dysfunction it's that not eating potentially harmful compounds prevents the insults in the first place. ounce of prevention is worth a pound of cure.

i also couldnt disagree with this statement more "Our pre-palaeolithic bodies are not adapted to be consuming animals several times a day." The preponderance of evidence points to the fact that we were only able to evolve big brains because we were able to procure enough calories in an efficient way i.e hunting big game, ever heard of the meat-loop? We literally drove the wooly mammoths to extinctioin, you dont think we were gorging on meat everyday??? Native americans drove herds of bison off cliffs by the thousands... and got plenty of vitamin C by passing around the raw liver to every man after a kill. There is also evidence that average brain volume has decreased since the agricultural revolution, when we stopped eating so much meat. Remember civilization is the master disease. THere's a reason we have an archetypical image of the toothless crazy dicrepid peasant farmer from medieval europe, they were lucky if they got meat once a week.

oh and you forgot to debunk me on omega 3's too which coincidentally have antioxidant activity without any associated toxicity from xenohormetic compounds found in plants which are actually classified as oxidants, the antioxidant response is done in via endogenous glutathione upregulation... something you can easily trigger via exercise, cold heat exposure, hypoxia or fasting without need for plants.

I really think the insulin resistance thing doesnt get enough attention though, this is critical for bridging the gap on this debate. The short term improvements with regard to insulin resistance make people very dogmatic about veganism, but it seems to be a mirage when you weigh all the other facts.

[montecristo]

@Michael569

there are plenty of people who stop eating all plant foods and see dramatic reversals in many of their degenerative conditions in short order even autoimmune diseases like type 1 diabetes https://www.ijcasereportsandimages.com/archive/2014/010-2014-ijcri/CR-10435-10-2014-clemens/ijcri-1043510201435-toth.pdf. It doesnt seem like these people are experiencing rapid aging as a result of not getting polyphenols. I dont really see how jordan peterson is marketing his diet, he mentioned his personal experience on a podcast.

what's pro inflammatory for one person may not be for another and vice versa. Microbiome science is in it's infancy and it's likely we will need AI and supercomputing to start making headway on the seemingly infinite fractal of interaction between the various organisms in our gut, spit swapping and transforming substances from one thing to another. It seems cut and dry that you eat fiber and bacteria process it and produce short chain fatty acids but in reality depending on the microbial makeup any given input in the form of food has no guaranteed output. The end product could be something very toxic or very healthy, no reason to rely on this. the other function of the microbiome is to allow us to be exposed to various compuounds without ill effects because the microbiome will in many cases intercept and neutralize them.

I agree and am aware of everything you said about LPS in and of itself and also the various causes of permeability you mentioned but there are other factors at play, namely plant defense compounds. According to sadhguru nothing that lives wants to be eaten, and they ALL have strategies to avoid being eaten, animals and plants alike. Why would we eat things that require us to "tolerate" them. THis implies that they are damaging in some way

I would be interested to see research on saturated fat stiffening the phospholipid bilayer and how that translates to rendering inuslin ineffectual shuttling nutrients into the cell, I was unaware of this. On it's face it sounds weird though given that the precursor to the phospholipid bilayer is saturated fat, but what do I know. I am aware that rancid oxidized cooked and processed plant oils cause massive free radical damage and oxidative stress though. Saturated fat is less likely to oxidize at temperature because the hydrogen bonds are more tightly knit with less surface area.

What I have noticed is that my vitamin D levels finally went up significantly after being deficient my whole life while supplementing, to accomplish this i stopped supplemting ironically and dramatically increased the amount of saturated fat in my diet, I dont even get any sun. Of course the meat I eat is of high quality, because of course factory farming is undefensible.

There are too many confounds to name with epidemiological studies rendering them next to meaningless. I do trust unbiased anecdotes because at least they are a holistic assessment and it really doesnt matter what some diluted study or narrow mechanism shows when my health IS an n=1 anyway, so self experimentation and macro outcomes are what matter to me. The qualitative difference in health is the highest standard of evidence for me above all others period.

I'd genuinely be interested to know if there are any direct antioxidant compounds that are found in plants, because as far as Im aware they dont exist and are all stimulating endogenous antioxidant upregulation. 

The rich lords in the UK were almost certainly consuming plant foods in one form or another, likely in the form of bread and alcohol if not other non-rotten farmed produce, which of course will cause disease and insulin resistance along with a meat and dairy heavy diet. THere's a reason when given the chance the first thing people start eating more of is meat, it's naturally palatable for a reason. Animals in nature dont have dental problems, indigenous human populations also dont have dental problems, remember civilization is the master disease.

All of this starts gets into the hierarchy of energy substrates that can be utilized to run the krebs cycle. To give a simplistic outline from inefficient and highest ROS producing to least it goes, alcohol, glucose, lactate and finally ketones. 

Ketones are ulitmately the optimal primary energy substrate for human metabolism, glucose on it's own is just like alcohol in that any excess cant be stored, just radiated as waste heat. Fat on the other hand doesnt get wasted in our metabolism, it all gets stored and utilized perfectly and efficiently granted you dont have excess glucose or alchohol gumming up the system. Oxygen consumption also goes down to 70% of what is necessary to metabolize glucose arresting the aging process related to oxidative damage, making it so in my experience i can hold my breath about twice as long while in ketosis.

MTHFR is especially common in asian phenotypes which heavily favor consumption of animal foods as it happens. I dont think good data exists on this though population wide though.

It seems like you are very well informed but if you arent aware of evolutionary biology you are missing a massive chunk of the story and imho the most important part. How do you think youre even alive? It's because your ancestors were optimized to their particular environment and all of their forebears as well. At the end of the day what matters when it comes to health is how well are you adapted to the environment. It's very difficult to change innate biology in the span of a lifetime or even many generations so it just makes sense to try to recreate an environment that matches the one we evolved in to begin with, maybe that will change with gene editing who knows

[Hello from Russia]

@Michael569

You seem very knowledgable about the topic, a lot more so than I am (although I know a pretty lot about this stuff too).

What is your favorite diet for health and productivity (clarity of mind)? 

I personally lean-to dairy-free gluten-free plant-based vegan diet lately with a moderate to high amount of fats. I eat legumes everyday but besides them I try to eat less carbs (Especially stuff like rice).  I eat things like nuts and seeds instead, although in moderation, because too much of nuts is toxic as well. So, instead of having typical 400g+ carb\day veg diet I only consume 150-200 carbs on average.

My main challenges are overconsumption of fiver (can quickly go 50+ of fiber with all these legumes, nuts and veggies), difficulties with filling up calories (I now use potatoes\oats to do that) and the lack of candy (I plan to bulk-buy plant-based protein bars and different vegan sugar-free candies in the future, but these are a bit costly).

We also have a pretty good plant-based milk company here in Russia called "Nemoloko" which costs only around 2$ per littre. Moloko means Milk => Nemoloko = Nomilk. I tend to avoid Rice Milks because of their arsenic content (and rice in general), so these oat guys are very handy.

 

Edited May 13, 2020 by Hello from Russia

[montecristo]

@Michael569

Cheers! Always up for a friendly debate and information exchange. I love having my beliefs challenged and acknowledge them as beliefs and an approximation of what might be true, a solid useful model to filter decisions through is my goal ultimately.

As soon as research starts getting fired back and forth it get's too involved i agree and in this context we can take each other at our words, i trust the information you provide is accurate although all perspectives are obviously partial.  The article i sent you is quite unique in that the poor guy's c-peptide came back to normal which was thought to be impossible for a type 1. This in my opinion has broad implications for all autoimmune conditions.

eager to see what you dig up on saturated fat