5-MeO-DMT for longevity - Bryan Johnson

[Leo Gura]

24 minutes ago, integral said:

They have to be showy on social media its the only game in town, society forces this behavior.

No. They are peak corruption.

They sold their souls to get in bed with Trump.

These billionaires are scum. I see right through their BS. I don't care how much 5-MeO they take or whatever other gimmicks.

Edited March 29 by Leo Gura

[integral]

40 minutes ago, Leo Gura said:

No. They are peak corruption.

They sold their souls to get in bed with Trump.

These billionaires are scum. I see right through their BS. I don't care how much 5-MeO they take or whatever other gimmicks.

But Brian is nothing like Trump, Elon and all the tech Bros?

He hasn't done any of those corrupt things yet, you're assuming he's going to?

In the past, you told me that we need less conscious people then you running for politics because you are too conscious for politics no one is ready for that level of truth.

I mean, Brian is as good as it's going to get when it comes to improving the healthcare industry at this level of development.

Edited March 29 by integral

[Leo Gura]

8 hours ago, integral said:

But Brian is nothing like Trump, Elon and all the tech Bros?

I don't know what he has done.

I wasn't speaking about him per se. The All-In guys.

[Asayake]

It’s easy to hate on Bryan Johnson just cause he wants to live forever and does everything in the name of longevity. People claiming what he’s doing is meaningless. But why choose hate and belittling his mission? Ask yourself if what you’re doing with your own life is more meaningful, it seems like you’re putting him down to feel better about your own life. Truth is Bryan Johnson is rich, healthy and pursuing a topic that he’s passionate about. If that’s meaningless then 99% of humans on earth are just meaningless lumps of cells. To me this isn’t insightful but just nihilism in disguise.

[cistanche_enjoyer]

[Lyubov]

I’m a bit envious that this guy can just afford to do life changing psychedelics and make a giant spectacle out of it with a camera crew filming and social media posts galore afterwards. 

Here I am working full time and building a foundation for success and a future family lol, something like that could derail me in a way I don’t want to put energy into recovering form. But to be honest I’m very much spiritually aware and have prioritized it since 2015, so the fruits of my labor have been paying off even if my experience is just around shrooms and ayahuasca. I shouldn’t frame it like I’m missing out on anything. I would imagine you can only garner so much wisdom when your original intentions are clouded. 

I guess what I’m getting at is he is literally the last person I would probably try to emulate when it comes to seeking peak experiencie. His whole Richie rich life is just so different from mine. I’d probably keep a good bit of it to myself if I were to do it and largely do my own journaling, talk here some about it. 

He also doesn’t look particularly young for his age. Is he really much more healthier than other guys his age? My grandpa lived to 92 and didn’t do shit for like 25 years before passing . Ate a pack of bacon daily and spent his retirement sitting in a recliner watching tv he recorded on a VCR. 

Maybe I’m being a hater but there’s something just performative about the way he moves that I don’t like. 

Edited April 1 by Lyubov

[integral]

3 hours ago, cistanche_enjoyer said:

Sleeping a lot makes sense if you have kid biology.

[bazera]

Lol, I liked the top comment.

And even 5meo.

[Leo Gura]

That's why I never trust these damned billionaires.

They got enough money to be stupid indefinitely.

[OBEler]

On 11.3.2026 at 9:50 PM, Leo Gura said:

Yes

Normal trip

It wasn't gradual. But I did many days of 5-MeO.

@Leo Gura Could it be that you did that one 5 Meo trip on a day where your nervous system was already active , you were in a stressful period?

[integral]

Death is a compelling marketing approuch but he should really make it about state.

The point is being in peek condition, not draggling your feet with brain fog through life and no purpose that 99% of slaves are doing. 

[Natasha Tori Maru]

6 hours ago, integral said:

Death is a compelling marketing approuch but he should really make it about state.

The point is being in peek condition, not draggling your feet with brain fog through life and no purpose that 99% of slaves are doing. 

This is a good point. 

In an interview with Dr Mike, Bryan was challenged on his Don't Die ideology. Mike raised the example of people who suffer from chronic pain, health issues and terrible life circumstances and queried how 'Don't Die' is for everyone given these people aren't in the position of privilege Bryan is in.

Bryan diverted twice and avoided addressing the question. 

I think quality of life, health and state are a big part of living longer; who the fuck wants to live longer in chronic, incurable pain? 

He has good intentions, but Bryan's philosophy is poor.

Edited Friday at 03:22 AM by Natasha Tori Maru

[Florian]

On 10.3.2026 at 8:33 PM, Leo Gura said:

I don't know that he so much fears death as he literally has nothing better to do. He needs to feel like he's doing something important and revolutionary, something historic, like he is some kind of pioneering genius. That's the ego trip.

It gives him a sense of life purpose. So he is grasping at straws to pioneer stuff.

He is though. 

Seems to me like everyone here has a wrong vibe of the guy.

2 things:

-he is not afraid of death, he accepted it when he was in deep depression

-its not just about living longer but about improving legitimately everything in life right now 

 

I heard so many people say "if you invest all your time in your health you have no time left to live" which is so wrong. You get more time and can enjoy the time better.

 

And also im pretty sure this big focus on health is nececarry for human kinds next big leap, so he is building the foundation for that.

[Florian]

On 11.3.2026 at 0:12 AM, Leo Gura said:

 

On 11.3.2026 at 0:12 AM, Leo Gura said:

It's even more silly to think that 3 uses of mushrooms will make any improvement to your health.

The only way 5-MeO might increase longevity is if you consume it regularly for years and decades.

No three uses of anything will increase your longevity. This is classic snake oil sales.

If he isn't even prepared to take it chronically for a least a year, he's even less serious than I gave him credit for.

I have taken 5-MeO for over 90 days. I did more experiment on this issue than he is planning to do.

 

It did though, he has measured it. Long term nervous system and hormonal changes.

What if you dont take into account that the impact is affected by the state of your system when consumed?

 

I think calling him unserious is laughable. Have you even followed him closely for a bit? He is 100% commited to this.

[Florian]

On 11.3.2026 at 0:19 AM, Leo Gura said:

I am not saying that. I am saying a thing must be chronic to have a chance of impacting longevity.

There's no pill for longevity. This is a childish idea.

He is already chronically optimizing sleep, exercise and diet + other chronic therapies like sauna and hyperbaric oxygen chamber. Shrooms or other psychedelics could act as reclibrater of your inner clock in a sense that only work if the rest of the system is in proper order, or just like the cherry on top. 

[Florian]

On 11.3.2026 at 0:24 AM, Leo Gura said:

Psychedelics have a cost.

The cost in terms of shrooms is your ability to reproduce. It damages sperm health. Might be similar with other psychedelics.

[Florian]

On 11.3.2026 at 2:44 AM, Leo Gura said:

This just opens the door a mile wide for these health influencer grifters to sell you snake oil.

Longevity means the chemical increases the health of your body, directly. Not vague lifestyle changes.

Eating your own shit before each meal will increase your longevity just by making you not want to eat.

Anyone want to sign up for Leo's Shit-Eating Course? I promise you longer life. 100% backed by Science™.

I can reduce heart-disease and diabetes across the globe by 50% if everyone just eats a bit of shit before each meal.

Bro wtf is this. Obviously you are triggered by it in some way. Stop this shit. I think this health perspective would be perfect for you now. You already did maybe your greatest work in terms of Actualized.org, understanding and explaining reality and paid your prize for it in terms of health, now you seem to be in a kind of hole. You could just sit back, focus on health and let the fruits of your labour unfold. Bryan is literally bringing your abstract teachings into a specific, tangible, physical form. 

[Florian]

On 11.3.2026 at 5:18 AM, Leo Gura said:

I've taken more 5-MeO-DMT than any of these so-called scientists and I have experienced damage from it.

I will go by my experience than their artificial studies.

But, hey, you do you. When you finally get hurt, don't say I didn't warn you.

maybe you overdid it???

[Florian]

On 11.3.2026 at 9:32 AM, Leo Gura said:

But I suspect it is not good for anyone long-term. Psychedelics tax the brain. You don't pour jet fuel into your car engine expecting longevity.

But maybe if your car was alive and capable of evolution you could put jet fuel in it slowly for it to adapt.

[Florian]

On 11.3.2026 at 10:53 AM, AION said:

Anybody who says he found the holy grail should be categorically discarded. Obviously certain things add to your health, but it is never in isolation. Every benefit has its costs too. And every cost has its benefit. In general everything that is synthetic and not natural is not good. So that is why I´m warry of DMT and putting it in places that it shouldn´t be put in. God is the best of designers until now so I prefer mushrooms, truffels and stuff.

When you understand basic stuff like your dopamine system and hemostasis, and have basic common sense, you automatically become extremely caution about concentrated synthetic drugs. 

When did he say he found the holy grail with that? Its just a piece of the puzzle