5-MeO-DMT for longevity - Bryan Johnson

[Leo Gura]

1 hour ago, OBEler said:

Which of these damages were occurring exactly? Sleep disorders or something? A burning sensation in your brain? Which damages of them were temporary, which permanent?

I got cerebral inflammation.

It eventually healed, but permanent nerve damage was done.

Edited 11 hours ago by Leo Gura

[Natasha Tori Maru]

Personality, I wouldn't be looking seriously at anything Bryan is doing for widespread application. He is N=1, a radical transhumanist and it is beyond apparent his entire gig is a grift now.

He only publishes his top data. Cherry picks. Dunno why people trust this guy. All his arguments fall flat when pushed. Listen to his interview with Dr Mike Varshavski. Or Derek from MPMD. More holes than Swiss cheese. 

[Leo Gura]

If 5-MeO increases longevity, I should live to be 500.

Lol

Edited 11 hours ago by Leo Gura

[bazera]

@Leo Gura Did you do more trips than Martin Ball?

It's also interesting if he experienced some health side-effects since he has done lots of that stuff.

Edited 11 hours ago by bazera

[Leo Gura]

4 minutes ago, bazera said:

Did you do more trips than Martin Ball?

I did less from what I understand.

He did a lot.

He did have serious sleep problems.

It's going to vary a lot by individual. Psychedelic effects are hugely variable.

Edited 11 hours ago by Leo Gura

[AION]

Anybody who says he found the holy grail should be categorically discarded. Obviously certain things add to your health, but it is never in isolation. Every benefit has its costs too. And every cost has its benefit. In general everything that is synthetic and not natural is not good. So that is why I´m warry of DMT and putting it in places that it shouldn´t be put in. God is the best of designers until now so I prefer mushrooms, truffels and stuff.

When you understand basic stuff like your dopamine system and hemostasis, and have basic common sense, you automatically become extremely caution about concentrated synthetic drugs. 

Edited 10 hours ago by AION

[OBEler]

1 hour ago, Leo Gura said:

I got cerebral inflammation.

It eventually healed, but permanent nerve damage was done.

I researched, cerebral inflammation can happen on a autoimmune disorder which you have. 

What was exactly the reason 5 meo did that. High blood pressure or serotonin syndrome or lack of oxygen?

[Leo Gura]

16 minutes ago, AION said:

Anybody who says he found the holy grail should be categorically discarded.

I found the Holy Grail.

[Leo Gura]

13 minutes ago, OBEler said:

I researched, cerebral inflammation can happen on a autoimmune disorder which you have. 

Where did you research it?

What did it say?

I don't have an explanation.

[AION]

8 minutes ago, Leo Gura said:

I found the Holy Grail.

You know what the Holy Grail is right? It cures all ailments. Both spiritual and physical.

[Leo Gura]

4 minutes ago, AION said:

You know what the Holy Grail is right? It cures all ailments. Both spiritual and physical.

The Holy Grail is Infinite Love.

You been watching to much Indiana Jones.

Edited 10 hours ago by Leo Gura

[cistanche_enjoyer]

1 hour ago, Leo Gura said:

It's going to vary a lot by individual. Psychedelic effects are hugely variable.

Exactly. You can hate on Bryan Johnson for selling snake oil and being corrupt, but at least we can agree that he is healthy. 

I’m looking forward to seeing what comes out of this experiment. Who knows, maybe in a body that is 100% metabolically healthy, “pouring jet fuel” could have some interesting beneficial effects.

[Carl-Richard]

12 hours ago, Carl-Richard said:

To add to that, the hippocampus is involved in the HPA axis (involved in fight-or-flight) where it sends inhibitory signals. Decreases in hippocampal volume is associated with decreased stress tolerance, and the hippocampus also shrinks from large amounts of stress. It explains why stress can lead to memory problems (as the hippocampus is famously involved in memory formation). So things that increase hippocampal functioning have positive effects on stress which ties to longevity.

Do people know that SSRIs are thought to work partially by rebuilding the hippocampus and then when you're back to a normal level, you can actually stop taking them and you're better off than you were (granted other side effects; I'm not suggesting to hop on SSRIs necessarily)? If 5-MeO does something similar with irregular doses (and less side effects), it might be a good longevity agent (but of course, the Default Mode Network effects might be even more important, as it sustains the stress response through repetitive thinking).

Edited 4 hours ago by Carl-Richard

[OBEler]

@Leo Gura i asked Gemini. Yes I know you should research for your self. 

Gemini: Cerebral inflammation (encephalitis or vasculitis) following 5-MeO-DMT use is extremely rare in medical literature, but there are scientific frameworks that explain how this could happen—especially when an autoimmune condition is part of the equation.

Here is a breakdown of the potential mechanisms:

1. The Blood-Brain Barrier (BBB) & Serotonin

5-MeO-DMT is a potent serotonin agonist. Serotonin plays a sophisticated role in regulating the blood-brain barrier.

Permeability: High activation of serotonin receptors (specifically 5-HT2A) can temporarily increase the permeability of the BBB.

Immune Infiltration: If this barrier is weakened, immune cells or inflammatory factors from the bloodstream can enter the brain tissue—areas they are usually strictly barred from. In a system where the immune response is already "primed" or hyper-reactive due to an autoimmune condition, this can lead to an acute inflammatory cascade within the central nervous system.

2. Drug-Induced Aseptic Meningitis (DIAM)

There is a clinical phenomenon where certain substances trigger an inflammatory response in the linings of the brain.

The Autoimmune Connection: Patients with existing autoimmune disorders (like Lupus or Rheumatoid Arthritis) are statistically at a higher risk for DIAM.

Hypersensitivity: This is essentially a Type III or IV hypersensitivity reaction. While some research suggests 5-MeO-DMT has anti-inflammatory properties via the Sigma-1 receptor, in a complex or predisposed immune environment, it may paradoxically act as a "trigger" that the body misidentifies as a threat, launching a massive immune attack.

3. Physiological Stress (Hypertension & Hyperthermia)

The physical intensity of a 5-MeO-DMT experience can put extreme stress on the body’s regulatory systems.

Vascular Stress: A sudden, massive spike in blood pressure can cause microvascular damage or lead to PRES (Posterior Reversible Encephalopathy Syndrome), which involves brain swelling and inflammation.

Thermal Damage: Extreme hyperthermia (overheating) during a high-intensity experience can damage nerve tissue directly and trigger a secondary inflammatory "cleanup" response that can spiral out of control.

4. Documented Cases & Reality

In formal medical journals, specific reports of 5-MeO-DMT causing encephalitis are nearly non-existent. Most clinical focus remains on Serotonin Syndrome, which in severe cases causes brain damage through seizures or oxygen deprivation.

However, in anecdotal "trip reports" and harm-reduction communities, there are scattered accounts of long-term neurological "re-triggering," brain fog, and inflammatory-style symptoms. These cases are rarely studied clinically, leaving a gap in our understanding of how the substance interacts with complex immune profiles.

Edited 2 hours ago by OBEler

[Leo Gura]

@OBEler

Thanks for sharing.

That is good info.

[Jodistrict]

I tried Ketamine and got a severe body rash over my back legs and arms.   I am going back to my rule – only natural substances.   I will stick to Bufo, if I ever take it again.

[Nemra]

4 minutes ago, Jodistrict said:

I am going back to my rule – only natural substances.

Why wouldn't naturally occurring substances cause harm?

[Jodistrict]

2 minutes ago, Nemra said:

Why wouldn't naturally occurring substances cause harm?

This is the beginning of a pointless argument.  Do what you want.  

[Leo Gura]

13 minutes ago, Jodistrict said:

I tried Ketamine and got a severe body rash over my back legs and arms.   I am going back to my rule – only natural substances.   I will stick to Bufo, if I ever take it again.

Naturalistic fallacy.

Bufo is literally a nasty toxin.

Edited 2 hours ago by Leo Gura

[Nemra]

16 minutes ago, Jodistrict said:

This is the beginning of a pointless argument.

I think that categorizing the harmful effects of psychedelics by their origin is pointless.

Psychedelics aren't food.

Edited 2 hours ago by Nemra