Trying Out a 4-Substituted Tryptamine & More

[Nemra]

15 minutes ago, LambdaDelta said:

Highly suggest trying at least one dissociative while you're at it. They're hardly even a thing in North America, EU is the golden opportunity, maybe not for much longer. There's lots and not all are any good, but ones that are give a qualitatively different experience either standalone or in amazing synergy with 4-subs.

I haven't thought about trying dissociatives. I don't know.

[LambdaDelta]

4 minutes ago, Nemra said:

I haven't thought about trying dissociatives. I don't know.

Worth it to get a reference if nothing else. DMT, 4-subs, LSD are more like flavors of the same thing. This is another entirely, as are Salvinorin & 5MD.

[Nemra]

@LambdaDelta, which ones are good?

 

[LambdaDelta]

1 minute ago, Nemra said:

@LambdaDelta, which ones are good?

 

Of ones still available, DMXE, MXPCP, O-PCE, 3-HO-PCP. Latter 2 are strong and unpredictable, perhaps not an optimal intro to the class. MXPCP is very recent but promising. Which leaves DMXE, it's soft and warm, fantastic synergy with 4-HO-MiPT. Only pellets around now, seems that's what you prefer anyhow.

[Nemra]

3 minutes ago, LambdaDelta said:

DMXE

What's the ROA for that?

[LambdaDelta]

4 minutes ago, Nemra said:

What's the ROA for that?

Only oral cause pellets, otherwise just about any works.

[Nemra]

On 10/18/2025 at 0:17 AM, LambdaDelta said:

If you can't get pure LSD-25, go for 1P-, and this should be the last chem you do.

@LambdaDelta, why get those variants? Why not other variants?

Edited October 20 by Nemra

[LambdaDelta]

17 minutes ago, Nemra said:

@LambdaDelta, why get those variants? Why not other variants?

Nothing comes close to the original, provided it is highly pure and accurately dosed, which most of it is not. You want 98.5% purity and above, with as little Iso-LSD as possible. Look into DS-3.0 if interested, but it is nontrivial to obtain. 

The 1x- are all prodrugs. The more recent like 1V or 1S are weaker, they're simply running out of legal tweak options. 1P/1D is fine. Other lysergamides are either weak or duds, ETH-LAD is cool though. 

[Nemra]

@LambdaDelta, is the potency of LSD-25 and the 1D/1P variants nearly the same per μg?

Also, what about AL-LAD?

 

[Nemra]

14 minutes ago, LambdaDelta said:

Look into DS-3.0 if interested, but it is nontrivial to obtain. 

I know the website, but I haven't put time into understanding how to purchase.

[LambdaDelta]

23 minutes ago, Nemra said:

@LambdaDelta, is the potency of LSD-25 and the 1D/1P variants nearly the same per μg?

Also, what about AL-LAD?

 

No, at least 15% lower based on MW, plus whatever metabolic differences. AL-LAD is eye candy with a weak headspace. 

[Schizophonia]

On 17/10/2025 at 10:19 PM, Leo Gura said:

All 5-MeO's have no tolerance.

No 5 MeO Mipt has a tolerance of one to two weeks

[Nemra]

2 minutes ago, LambdaDelta said:

No, at least 15% lower based on MW, plus whatever metabolic differences. AL-LAD is eye candy with a weak headspace. 

Is what you're saying apply to almost everyone?

[LambdaDelta]

8 minutes ago, Nemra said:

Is what you're saying apply to almost everyone?

Generally. You ask too many basic questions man, there's no need for me, this information is readily available. Read the reports and make conclusions, or test on yourself. 

[Nemra]

5 minutes ago, LambdaDelta said:

Generally. You ask too many basic questions man, there's no need for me, this information is readily available. Read the reports and make conclusions, or test on yourself. 

Anyways, thanks for putting the time answering.

Talking to a live person with experience is different.

[Oppositionless]

On 10/16/2025 at 1:06 PM, LambdaDelta said:

Cause only 4-HO-MET, 4-HO-MiPT, and 4-AcO-DMT are worthwhile and you won't get the 4-AcO. In any case doing a 4-sub when you already have N,N-DMT is fairly redundant, if it's such a rare opportunity get some 5-MeO-DMT, an LSD analogue, or a dissociative.

I'd you can't get 4-AcO-DMT, I've heard 4-PrO-DMT is extremely similar if not the same.

Edited October 21 by Oppositionless

[Mayonnaise]

@Schizophonia i would say it depends on the kind you have. i have 99% pure in tablet form. 14 mgs was wayyyy too much for me it was extremely intense. but like i said its all about how strong yours is

[Nemra]

I'm finding that, besides 5-MeO-DMT, 5-MeO's have a longer tolerance that lasts more than a day.

Should I plug any 5-MeO freebase the same way like for 5-MeO-DMT freebase?

[Leo Gura]

I have never experienced a 5-MeO not working at full effect.

[Nemra]

15 minutes ago, Leo Gura said:

I have never experienced a 5-MeO not working at full effect.

Interesting.

It is written on psychedelic-related wikis that they have tolerance.

Though, I haven't tried them yet, maybe they don't have tolerance.

Edited Friday at 12:40 PM by Nemra