Psygenlab

Personal Research on Dangers of 5-MeO-DMT and MAOI, to see if there is a safe way of

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I did some hours of a conversation with Gemini with google search, and here is the cleaned up, final draft of my research.
still very vague, but good point to start.

My initial curiosity revolved around whether the 5-MeO-DMT and MAOI combination could be safer than generally believed. If so, it might open avenues to explore prolonged states of nondual consciousness. However, there are clear cases resulting in death and severe serotonin toxicity. Despite research, it remains unclear why 5-MeO-DMT is dangerous with MAOIs while N,N-DMT is generally considered fine. I currently lack the resources and knowledge to conduct such experimentation, so I will not be pursuing this experiment anytime soon.

Main Insights:

5-MeO-DMT combined with MAOIs can lead to blood concentrations 100-300 times higher than typical effective inhaled doses of 5-MeO-DMT. This suggests an experience potentially 100-300 times stronger than a high-dose "whiteout" smoked experience.

Considering 5-MeO-DMT's 100-fold higher affinity for the 5-HT1A receptor compared to N,N-DMT, and the MAOI's effect on metabolism, the combined "signal" on this receptor could be ten thousands of times stronger than N,N-DMT's effect in ayahuasca

so, 5-MeO-DMT with MAOI can be at least 100 times stronger than expected, upto 10000 times.
(1mg -> 10g effect?)

The Danger: 5-MeO-DMT + MAOI

Mixing 5-MeO-DMT with MAOIs is dangerous. This combination often leads to Serotonin Toxicity, a severe condition.

Symptoms of Serotonin Toxicity include:

Anxiety

Hypervigilance

Rapid heart rate

High blood pressure

Elevated body temperature

Excessive sweating

Seizures

Severe muscle rigidity

Unlike the relatively short duration of smoked 5-MeO-DMT (around 20 minutes), the effects with MAOIs can last at least 4 hours, potentially causing the body to overheat severely. By default, this combination is hazardous. Medical supervision and safety backups (like "trip killers" and counter-actions to serotonin toxicity) are essential for any safe experimentation, if it were even possible.

The 2005 Fatal Case: A Stark Example

In 2005, a 25-year-old male died after ingesting 5-MeO-DMT and MAOIs. Post-mortem analysis revealed:

Blood Concentration: 1.88 mg/L (or 1880 ng/mL) of 5-MeO-DMT in his heart blood.

Stomach Content: 201 mg/L of 5-MeO-DMT. (Note: This doesn't mean he ingested 201 mg directly; it's a concentration in the stomach contents).

To grasp the magnitude of exposure, compare the blood concentration found to typical effective doses:

Fatal Blood Concentration: 1880 ng/mL.

Typical Effective Inhaled 5-MeO-DMT (without MAOIs): 5-20 ng/mL for a profound, non-lethal experience.

The 1880 ng/mL found in his blood is roughly 100-300 times higher than concentrations typically seen with effective inhaled doses. This suggests his experience was likely orders of magnitude more intense than a high-dose 5-MeO-DMT experience. While a precise ingested dose cannot be calculated, an estimated total amount in his body at death could be around 394 mg, though this is a vague assumption.

Ayahuasca (N,N-DMT + MAOI): A Different Story

The human body contains MAO-A enzymes, primarily in the gut, which break down both 5-MeO-DMT and N,N-DMT. Ayahuasca, by mixing MAOIs with N,N-DMT, aims to prolong the experience of DMT.

However, the outcome is different:

N,N-DMT Blood Concentration Comparison:

Smoked/Vaporized N,N-DMT (without MAOI):

Typical peak plasma concentrations (Cmax) range from 10 ng/mL to 80 ng/mL.

Peaks are reached rapidly (minutes), then decline quickly (half-life 5-15 minutes).

Oral N,N-DMT in Ayahuasca (with MAOI):

Typical peak plasma concentrations (Cmax) for N,N-DMT in ayahuasca sessions generally fall within the range of 10 ng/mL to 100 ng/mL.

Examples: ~33 ng/mL in one study, 12.14-17.44 ng/mL in another.

The MAOI enables oral activity, leading to a slower onset and longer duration (4-6 hours), but the peak concentrations are often numerically similar to smoked DMT.

For N,N-DMT, the MAOIs in ayahuasca primarily enable oral bioavailability and prolong the duration, rather than causing a drastic increase in peak blood concentration to toxic levels. This is why a 200-300 mg oral dose of N,N-DMT in ayahuasca might be considered a high but manageable dose, while a similar dose of 5-MeO-DMT with an MAOI is lethal.

The Core Question: Why the Drastic Difference in Accumulation?

This leads to the central question: Why was there significantly higher 5-MeO-DMT in the blood in the fatal case, despite both compounds being metabolized by MAO-A and both scenarios involving MAOI inhibition?

The answer lies in inherent potency and receptor affinity:

5-MeO-DMT: The Focused "Spear"

It has an at least 100-fold higher affinity (Ki: 1.9 nM) for the 5-HT1A receptor (linked to ego-dissolution) compared to N,N-DMT (Ki: 183 nM).

This means 5-MeO-DMT is incredibly efficient at activating this specific receptor. A tiny amount can produce a profound effect. When its breakdown is blocked by an MAOI, this highly potent compound accumulates rapidly to overwhelming, toxic levels.

N,N-DMT: The "All-Rounder"

N,N-DMT is less selective, acting on 5-HT1A, 5-HT2A (responsible for visuals), and many other receptors.

While MAOIs enable its oral activity, its lower inherent potency means that even with inhibited breakdown, the peak concentrations reached are generally within a range that produces intense psychedelic effects without immediate systemic toxicity.

Two main hypotheses emerge for the extreme 5-MeO-DMT accumulation:

Synergistic Overload: The combination of 5-MeO-DMT's 100-fold stronger affinity for 5-HT1A and a significantly reduced metabolization speed due to MAOI means the "signal" from 5-MeO-DMT is hitting the 5-HT1A "button" ten thousands of times more strongly and frequently. This leads to a rapid and severe overstimulation of the serotonin system.

Accidental Overdose: It's possible the individual simply ingested an extremely high dose of 5-MeO-DMT, perhaps mistaking its potency for that of N,N-DMT, leading to a massive overdose that even partial MAO inhibition turned lethal.

Conclusion:

Disciplinary experimentation and rigorous execution are still needed to fully understand if a safe way to combine 5-MeO-DMT with MAOIs exists. Even if theoretically possible, the extreme potency of 5-MeO-DMT and the narrow margin for error mean that miscalculation or confusion could easily lead to death. Safety backups, medical supervision, and immediate counter-actions for serotonin toxicity would be absolutely critical for any such endeavor. By default, mixing 5-MeO-DMT and MAOIs remains highly hazardous.

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I've done it. It's dangerous. Don't do it unless you are cool with death.


You are God. You are Truth. You are Love. You are Infinity.

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12 hours ago, Leo Gura said:

I've done it. It's dangerous. Don't do it unless you are cool with death.

Were you aware of the risks before doing it? This sounds really frightening. 

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33 minutes ago, integration journey said:

Were you aware of the risks before doing it? This sounds really frightening. 

Yes


You are God. You are Truth. You are Love. You are Infinity.

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@Leo Gura why were you using MAOI’s; if you don’t mind to answer. And why would you risk life combining with 5meo… seems dumb.  

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From my experience 5 meo dmt dissolves the self, so I mean, how could an experience be 100 times stronger?

If a high dose of 5 Meo dmt leads to 100% ego dissolution, meaning 0 percent ego left. How could an experience be stronger than that? I mean there can’t be negative self dissolution beyond zero. Either it’s gone or there’s some ego left, can’t go further right ?

Like how is there MORE or LESS infinity lmao either it’s infinite or limited

Or am I wrong here?

 

Edited by Sugarcoat

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16 hours ago, LostSoul said:

And why would you risk life combining with 5meo

Because I don't believe anything or anyone. I test everything for myself.


You are God. You are Truth. You are Love. You are Infinity.

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3 minutes ago, Leo Gura said:

Because I don't believe anything or anyone. I test everything for myself.

Did you get any side effects?

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