That's a deep topic.
If you're serious, you should spend the next 5 years contemplating and studying all the points I made in the videos. This is not something you just follow a list of bullet points on. You must think profoundly about these epistemic issues as you go about learning and doing science.
No one is gonna hold your hand towards groundbreaking, genius-level science. That's your job to figure out and then convince the world of your discoveries. People will not like your discoveries.