Tofu association with cognitive decline, dementia

[mostly harmless]

 

2021

Midlife Intakes of the Isoflavone Genistein and Soy and the Risk of Late-life Cognitive Impairment: The JPHC Saku Mental Health Study

https://www.jstage.jst.go.jp/article/jea/advpub/0/advpub_JE20210199/_pdf/-char/en

 

2021

Effect of Polyphenols on Cognitive Function: Evidence from Population-based Studies and Clinical Trials

https://link.springer.com/article/10.1007/s12603-021-1685-4

 

 

2022

Is It Safe to Eat Soy?

https://www.globehealth.net/vegetarian-living/is-it-safe-to-eat-soy.html

 

 

 

 

[undeather]

The emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles.
Beyond food studies, results of single-nutrient studies have largely failed to be corroborated in randomized trials. Reform has long been due.

The data you provided is at best medium to low quality.

I think its definitely legit to focus some future reserach capacities on exactly this topic.
Causal corroborations of nutritional associations are rare, but they do happen.

However, I wouldnt be too worried about it  

[mostly harmless]

I assume that typical traditional diets in Japan depend on region.

Also the situation with Soy sauce and fermented Soy (Natto) might be different in terms of effects on health.

 

 

[Arthogaan]

@Michael569 thank you for that guy. Nice resource. How did you get to know him?

[ZenAlex]

I eat Tofu daily, but i'm not gonna worry too much about this. 

 

[StarStruck]

I eat tofu once in a while and this wants to make me stop. Damn, can’t a brother eat anything anymore?

[Yarco]

On 5/23/2022 at 5:07 AM, Michael569 said:

I asked the Nutrivore to share his thoughts on the study and got the response surprisingly fast. This seems like a pretty decent breakdown. The sodium component makes a lot of difference 

Is this just limited to cognitive decline, or what do you think this means for all the other claims about soy, especially when it comes to estrogen? Is it time to start doing studies on the effect that high sodium diets have on estrogen production in men? Is it just salt on its own? Or do you think there's some synergistic effect when you combine soy + sodium which is where the problem comes from?

I think there's also some data on estrogen causing an increased sensitivity to sodium, and higher sodium retention in the body? So eating soy might amplify the effect of sodium on the body?

If it's a salt thing, and cultures that eat a ton of soy also eat a ton of salt, then shouldn't we be seeing an epidemic of high blood pressure, heart disease, and strokes in places like Japan?