5-MeO-DMT for longevity - Bryan Johnson

[Carl-Richard]

32 minutes ago, Leo Gura said:

@Carl-Richard Dr Mike has joined the chat.

Mr.* Mike. I always correct it in my head when I read "Dr. Mike" now. The internet decided to revoke his PhD status.

[cistanche_enjoyer]

4 hours ago, Leo Gura said:

The psychedelc chemical itself is not increasing your health there.

Bro he literally posted about this with proof attached:

+ Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models. 

+ Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level.

+ Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness.

+ Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.

[Willy Phallicus]

4 hours ago, Cireeric said:

I definitely wouldnt bet on 5-MeO for longevity, but psylocibin seems very plausible to me.

Shrooms try to kill me every trip now.  Unless we're talking about micro dosing here which I dont bother with.

If psychedelics were that good for you more would be better and that's been proven demonstrably false many times.

The benefits of these types of drugs are mental, not physical - and still subject to abuse like anything else.

[Leo Gura]

25 minutes ago, Carl-Richard said:

Mr.* Mike. I always correct it in my head when I read "Dr. Mike" now. The internet decided to revoke his PhD status.

I'll give it to him, since PhD doesn't mean much to begin with in my head

Let the children have their PhDs. At least it makes them feel good about themselves. Emotional support certificates

17 minutes ago, cistanche_enjoyer said:

Bro he literally posted about this with proof attached:

+ Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models. 

+ Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level.

+ Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness.

+ Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.

Sounds like BS to me.

Edited 3 hours ago by Leo Gura

[Carl-Richard]

22 minutes ago, cistanche_enjoyer said:

Bro he literally posted about this with proof attached:

+ Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models. 

To add to that, the hippocampus is involved in the HPA axis (involved in fight-or-flight) where it sends inhibitory signals. Decreases in hippocampal volume is associated with decreased stress tolerance, and the hippocampus also shrinks from large amounts of stress. It explains why stress can lead to memory problems (as the hippocampus is famously involved in memory formation). So things that increase hippocampal functioning have positive effects on stress which ties to longevity.

Edited 3 hours ago by Carl-Richard

[cistanche_enjoyer]

4 minutes ago, Leo Gura said:

Sounds like BS to me.

 

[Leo Gura]

I've taken more 5-MeO-DMT than any of these so-called scientists and I have experienced damage from it.

I will go by my experience than their artificial studies.

But, hey, you do you. When you finally get hurt, don't say I didn't warn you.

Edited 3 hours ago by Leo Gura

[VioletFlame]

Anything not used in moderation is damaging. Over-consumption is dangerous. So is over-indulgence. You have to learn when to step away from a delicious cake if you're already full. 

[Carl-Richard]

15 minutes ago, Leo Gura said:

I've taken more 5-MeO-DMT than any of these so-called scientists and I have experienced damage from it.

I will go by my experience than their artificial studies.

But, hey, you do you. When you finally get hurt, don't say I didn't warn you.

Maybe don't overdose on it? 😝

[Leo Gura]

21 minutes ago, Carl-Richard said:

Maybe don't overdose on it? 😝

I'm not even talking about the time I nearly killed myself for Alien Mouse. We'll just ignore that.

Edited 2 hours ago by Leo Gura

[Oppositionless]

None of these studies are catching the effects it has on the subtle body , the chakras and the nadis. I didn't believe in these things until my kundalini activated.

[OBEler]

2 hours ago, Leo Gura said:

I've taken more 5-MeO-DMT than any of these so-called scientists and I have experienced damage from it.

I will go by my experience than their artificial studies.

But, hey, you do you. When you finally get hurt, don't say I didn't warn you.

Can you elaborate? What damage exactly?

[Leo Gura]

29 minutes ago, OBEler said:

Can you elaborate? What damage exactly?

Body damage and brain damage.

[OBEler]

2 minutes ago, Leo Gura said:

Body damage and brain damage.

Can you specify? Were they all temporary? Do you still suffer from some of them?were they directly or indirectly?

 

Edited 23 minutes ago by OBEler

[Nemra]

2 hours ago, Leo Gura said:

I'm not even talking about the time I nearly killed myself for Alien Mouse. We'll just ignore that.

Was it traumatizing and too much, or did human life seem meaningless to you to return back?

[Leo Gura]

9 minutes ago, OBEler said:

Can you specify? Were they all temporary? Do you still suffer from some of them?were they directly or indirectly?

 

Direct. Some healed, some didn't.

[Leo Gura]

Just now, Nemra said:

Was it traumatizing and too much, or did human life seem meaningless to you to return back?

Not traumatizing.

Too beautiful to return back.

[OBEler]

10 minutes ago, Leo Gura said:

Direct. Some healed, some didn't.

Which of these damages were occurring exactly? Sleep disorders or something? A burning sensation in your brain?