how long to wait after MDMA for 5meo dmt?

[emil1234]

I had a therapeutic MDMA session 2 weeks ago, and ive never felt better ever since.

Zero comedown, ive basically felt on top of the world, and ive been able to work through a lot of past trauma.

my question is; how long should i wait before doing 5meo? online people give varying answers, some say that i need to wait 4-6 weeks regardless of how i feel.

i feel like thats a little long time, since i basically feel better than ever. 

U have any experience on this?

[Davino]

What arguments are they giving for having to wait such a long time?

There's a small chance of encountering serotonin syndrome, I've heard. But I've read many trip reports of people combining MDMA and 5meo, so I don't see how likely it is you encounter complications after 2 weeks unless you took such a massive dose that you haven't returned yet to brain chemical homeostasis (and that's why you feel so good, although I'd bet is because of the trauma dissolving, like dropping a heavy backpack)

[OBEler]

@emil1234 what doses did you take?

5 Meo DMT combination with MDMA seems save so far.

Edited May 16 by OBEler

[LambdaDelta]

No concrete experience per se, but at one point I was doing psychs so often that almost surely the above combination or a close relative of it was taken in under a two week period. No negative effects. 

You can do 5-MeO safely already, sufficient time has passed. 4-6 weeks is definitely nonsense. MDMA comedown is for ignorant suckers anyway. Without binging, clean product, and optionally supplementation, it will be no more taxing on the body than any other psych. 

Edited May 17 by LambdaDelta

[Jodistrict]

I don’t know anything about MDMA, but I would wait until it has metabolized entirely out of your body, whatever that period happens to be.  Don’t mix any drug with 5-meo.  The main issue is heart rate.   

[OBEler]

@LambdaDelta MDMA may not be taxing to the body but it is still neurotoxic.

[LambdaDelta]

1 hour ago, OBEler said:

@LambdaDelta MDMA may not be taxing to the body but it is still neurotoxic.

That forms part of what I mean by taxing on the body. In the first place, the mechanics of its neurotoxicity are poorly understood (not by science, but those that take it).

https://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metabolites/

https://www.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/

These should be mandatory reading for anyone using MDMA. Combined with acetone washing and potentially further purification. Undeniably it's neurotoxic, but with a correct procedure that can be inhibited or otherwise minimized. The significant effects on cognitive performance have overwhelmingly been observed in subjects with regular use or even abuse, cautious people needn't worry. It's not 4-CMA. 

[Schizophonia]

24h something like that 

[Aaron p]

Mdma + 5meo combo = slightly increased risk + significant decrease in fear 🔥🔥🔥 both together.

 

The risk is dose dependent. Be super careful as it technically increases risk of death. This is not advice just information for harm reduction purposes: from certain research it appears that the risk of death with this combo isn't substantial. Even 5meo alone risks serotonin syndrome.

 

On drug interactions chart the combo is listed as yellow "caution" and not orange "warning" or red "danger." 

You'd still need to be careful, objectively it would be safer to combine 5meo with diazepam as a method to try combat the fear. Don't assume anything when using combos. Always do your own extensive research. (But yeah I personally reached out to 5meo facilitators who claimed to witness hundreds of people use the MD+5meo combo with apparent safety).

Tryptamines are terrifying, mdma removes most fear. Big hack for the price of slightly increased risk. Start small and work up with (you guessed it) "caution." 

Bonus insight: you can use a drug called "cyproheptadine" to counteract serotonin syndrome if you feel it happening. 

Edited May 23 by Aaron p

[emil1234]

@Aaron p

oh i wasnt intending on combining the drugs - i merely wanted to know if i needed to wait a certain period of time before doing 5meo after a mdma session. its been 3 weeks now and wanted to know if im good to go for the 5meo trip
 

[Aaron p]

@emil1234 well...given the fact that you can take reasonable doses of both together simultaneously without entering the warning or danger zones...I would say it's pretty safe to take 5meo maybe 1.5 months after mdma. Or immediately after. You have to just analyse your own situation. 

The first thing you should think is "am I likely to be able to stay stable?" And "am I someone who doesn't struggle with addiction,"  and "can I handle heavy tripping?" If the answer is a clear "no" to all those questions then you need to apply more wisdom and care. 

If your younger you also need to apply more wisdom, it can be too early for some people. 

If your stable, well balanced, not going through a pivotal or difficult time and your usually ok with keeping your distance from addictive things and your strong enough to handle other dimensions...then maybe just wait 4-8 weeks after? 

The two drugs hit the serotonin system differently so it's not like with taking mdma over and over where you need to wait 3 months per time.

 

Here's the differences in bio chemical operation:

 

---

AI start:

---

MDMA and 5-MeO-DMT both act on the serotonin system, but they do so in different ways:

 

MDMA:

Releases large amounts of serotonin (5-HT) into the synaptic cleft by reversing serotonin transporters (SERT).

Also releases dopamine and norepinephrine, contributing to its stimulant and euphoric effects.

Prolonged or high-dose use depletes serotonin, which can cause a comedown or depression.

---

5-MeO-DMT:

Is a serotonin receptor agonist, especially at:

5-HT1A (calming, introspective)

5-HT2A (psychedelic effects, ego dissolution)

It does not flood the brain with serotonin, but mimics it at the receptor sites, especially in the brainstem and cortex.

It has very little dopaminergic or stimulant activity.

---

In Summary:

MDMA = forces the release of serotonin (and others).

5-MeO-DMT = directly stimulates serotonin receptors, especially 5-HT1A and 5-HT2A.

 

This distinction matters because after MDMA, your serotonin stores are low, and receptor systems can be desensitized—which may make 5-MeO either feel weaker, or conversely, hit unpredictably hard. Waiting gives your system time to rebalance.

___

2 weeks is widely considered the safest and most effective waiting period between MDMA and 5-MeO-DMT, for these key reasons:

---

1. Serotonin System Recovery

MDMA can significantly deplete serotonin and dysregulate receptor sensitivity.

Full recovery takes at least 10–14 days in most people, sometimes longer.

5-MeO-DMT relies heavily on 5-HT1A and 5-HT2A receptors—if these are desensitized, the trip may be blunted or destabilizing.

---

2. Emotional Integration

MDMA opens the heart, but it also leaves many people vulnerable or raw afterward.

Rushing into 5-MeO (which dissolves the ego) during that phase can lead to emotional overwhelm or traumatic ungrounding.

A 2-week buffer allows psychological and emotional re-integration.

---

3. Avoiding Serotonin Syndrome Risk

While rare, taking serotonergic substances too close together increases the risk of serotonin syndrome—a potentially life-threatening condition.

A 2-week gap lowers this risk to virtually zero, assuming no SSRIs or other serotonergic drugs are in your system.

---

If you're experienced and grounded:

Some psychonauts report waiting 7–10 days with no issues, but this is riskier and more dependent on individual neurochemistry.

---

Bottom line:

2 weeks is the optimal and responsible window—for safe

ty, potency, and psychological benefit.

Rushing

 

 

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AI end

---

 

Think about some of these points and carefully consider the variables and dynamics to your specific situation and biology ♥️ just remember that physical damage and addiction potential isn't the only thing...you can have psychological issues develop like psychological dependency/instability and whatnot. 

If it were me I'd wait 3 months then take them both together. Trypts way too scary for me alone. But this is me, not you. You must decide for yourself and research. Dose carefully, test each batch. Ultimately you make all your own decisions.

Edited May 24 by Aaron p

[Schizophonia]

Is MDMA psychedelic ? 🤔

[OBEler]

9 minutes ago, Schizophonia said:

Is MDMA psychedelic ? 🤔

Yes if you are very spiritual already. Otherwise it's just a high.

[Schizophonia]

1 hour ago, OBEler said:

Yes if you are very spiritual already. Otherwise it's just a high.

Because of serotonin neurotransmittion increasing i would think it is basically a psychedelic but more stimulant, close to LSD.

Edited May 26 by Schizophonia

[emil1234]

On 26.5.2025 at 8:33 PM, Schizophonia said:

Because of serotonin neurotransmittion increasing i would think it is basically a psychedelic but more stimulant, close to LSD.

my experience of it was extremely close to LSD. However when i did MDMA back in the day, 6-7 years ago it only had a stimulating, non psychedelic effect on me. dont know if its one of those drugs that changes after you've done psychedelics, like weed. perhaps. my mdma experience was very psychedelic

[LostSoul]

I would like to leverage this post to ask if you guys know if there is some risk combining LSD + 5meo. I'm talking about combining 20µg of LSD (a micro dose) to help with the pre-trip anxiety of 5meo. I once had microdose of LSD and felt very ready and fearless to take the 5meo if I knew that it isn't harmful

[OBEler]

5 hours ago, LostSoul said:

I would like to leverage this post to ask if you guys know if there is some risk combining LSD + 5meo. I'm talking about combining 20µg of LSD (a micro dose) to help with the pre-trip anxiety of 5meo. I once had microdose of LSD and felt very ready and fearless to take the 5meo if I knew that it isn't harmful

No problem at all. You can do that combination it's no problem on that low dose. On higher doses this might be too interfering. 5 Meo overwrites the LSD experience anyway because it's too strong.

Report please if you could reduce the fear with that, sounds like a good idea.

Edited May 30 by OBEler

[Aaron p]

Let's all be super careful with combos they can exponentially expand in the right or wrong direction. 

 

Bonus info about 5meo mdma combo:

On the drug interactions chart the ketamine + alcohol combination is a red warning and I have seen people do this. I myself did this combo once or twice before I knew it was dangerous (wasn't pleasant).

But if ket+alcohol is red warning and 5meo+mdma is two steps below it in risk level at a yellow caution...I mean, that sounds pretty fuckin safe like. 

Also considering that those drug interactions chart people are usually quite strict with what they say is safe and what isn't (seeing as they are literally responsible for life and death accuracy). 

Edited May 31 by Aaron p

[OBEler]

@Aaron p this drug interaction chart is just a superficial chart. Better research on your own what the risk/value of these combos are. 

[Aaron p]

23 minutes ago, OBEler said:

@Aaron p this drug interaction chart is just a superficial chart. Better research on your own what the risk/value of these combos are. 

@OBEler I'll let you know my findings