The 5-MeO-DMT Mega-Thread

[Leo Gura]

14 minutes ago, Nemra said:

@Leo Gura, ok.

I thought you were comparing freebase with HCL of 5-MeO-DMT regarding plugging.

They plug equally well.

[LambdaDelta]

On 11/19/2025 at 2:39 PM, Leo Gura said:

If you have the option to buy freebase or HCl, buy freebase. It is 10-20% more potent per gram, and it vapes well, and it plugs well. So this covers every use case.

The only point of salts is if you are going to IV it.

If you buy the salt, you will be limited in your ability to vape it, which is not ideal. You want that option.

Agree to disagree, I'll just present an alternative viewpoint. This on its own is myopic.

Sure, going by straight molar mass freebase is 17% more potent and therefore cost-effective. But what about loss during vaping? It decreases with refined technique and better equipment, but present nonetheless. A person just starting out is guaranteed to waste a bunch. There's degradation too, even though 5MD isn't nearly as bad as N,N-DMT in this aspect, it's still a factor, while any salt will outlive you with half-decent storage. And when making it available for rectal, especially with a kitchen tier tek like vinegar, you simply cannot guarantee that every molecule of 5MD will bond to an acetic acid one, so some are left out. 'Dissolve' isn't even the right term here unless you massively oversimplify. You are forming 5MD acetate, which then becomes water soluble, but with a bunch of excess acid, hence the sting. 
Converting from salt to freebase is both less technically involved, and far more forgiving if done lousily.
Lastly, salts tend to carry less impurities. You won't see this on a regular NMR, something more detailed like LCMS + GC is required.

In the end, why not get half-half of each, or whatever other ratio you think will suit your use.
Works both ways, if you want the option to vape, you also want the option to IM/IV. It ain't 'every use case' when 2/4 of potential ROAs are left out.

What's even the reason to 'suck it up' when you're about to enter a powerful trip, besides saving a few bucks and acting tough? You want as few distractions as possible. Similarly you wouldn't want to taste Salvia's awful harshness right before getting blasted into insanity consciousness.

[LambdaDelta]

It's so fascinating. You moved on from mushrooms to 4-AcO-DMT. From insufflation to rectal. From pipes to e-mesh. From Salvia to Salvinorin A. 

In the conformity video you have a full section on psychedelic conformity and how you were able to get qualitatively different results by being open to new technology, with the example of Ayahuasca vs. synthetic N,N-DMT. We're on the same page regarding how weed is pure stupidity next to THCA.

Yet there's a few areas where you still insist on using the same techniques you were back in 2018, maybe with a few tweaks. Like microscoops instead of volumetric dosing, or plugging instead of IM. Or this vinegar stuff. It's all good if you've tested every method and settled on the ones that are most effective and convenient for you, perhaps that is the case. But you speak as though no alternatives exist and these are the definitive methods, when in fact they may not necessarily be so for others, nor are they the most precise and rigorous. I know there's not enough time in the world to give every fine detail, especially many times over, but more nuance would be nice since most people take everything at face value.

It appears that conformity is not purely a collective phenomenon, it also exists as attachment to ideas and methods one has personally derived, and it is especially difficult to notice and escape when those actually work and are superior to whatever was out there at the time. 

[Leo Gura]

The vinegar is not for converting, it is for helping it dissolve in water. Freebase is active rectally without vinegar. So all of it gets absorbed and used regardless of conversion.

Vape carts waste nearly none of the chemical.

Using traditional pipes is wasteful, I agree.

IV seems pointlessly dangerous since the purity of the chemical is never certain.

Edited November 20 by Leo Gura

[Loveeee]

I've read here and elsewhere regarding 5meo and nausea that you're more prone to it in the first few trips, and also that fasting for too long (9h? 12h?) can be counter-productive ?

Apparently ginger helps but you're not supposed to eat or drink, so ? 

Edited November 21 by Loveeee

[Rahul yadav]

@Leo Gura where are you studying all of this research, where can i start?

[Leo Gura]

10 hours ago, Loveeee said:

I've read here and elsewhere regarding 5meo and nausea that you're more prone to it in the first few trips, and also that fasting for too long (9h? 12h?) can be counter-productive ?

Apparently ginger helps but you're not supposed to eat or drink, so ? 

Fasting is not necessary. Just don't eat for a few hours prior.

10 hours ago, Rahul yadav said:

@Leo Gura where are you studying all of this research, where can i start?

There's not one place. Much of it is my own experimentation.

But you can do a lot of basic research on Reddit, Erowid, DMT Nexus, the BlueLight forum, and Psychonaut Wiki.

Just google for what you need.

All answers exist on Google if you just aren't lazy to search deeply.

Edited November 21 by Leo Gura

[Loveeee]

58 minutes ago, Leo Gura said:

Fasting is not necessary. Just don't eat for a few hours prior.

So when am I supposed to take the ginger ? 

[Schizophonia]

On 19/11/2025 at 0:45 PM, Leo Gura said:

Suck it up, buttercup.

All normal man clenched his buttocks when he feels something trying to slip inside. 

Edited November 21 by Schizophonia

[Leo Gura]

1 hour ago, Loveeee said:

So when am I supposed to take the ginger ? 

Like 30 mins before.

I suggest drinking pure ginger tea. You can buy on Amazon. Ginger tea is quick and easy to consume.

This is not necessary, but if you have nusea issues then this can help.

Edited November 21 by Leo Gura

[Loveeee]

31 minutes ago, Leo Gura said:

Like 30 mins before.

I suggest drinking pure ginger tea. You can buy on Amazon. Ginger tea is quick and easy to consume.

This is not necessary, but if you have nusea issues then this can help.

Understood, thank you 

[Jordan]

On 2025-11-20 at 9:12 PM, Loveeee said:

I've read here and elsewhere regarding 5meo and nausea that you're more prone to it in the first few trips, and also that fasting for too long (9h? 12h?) can be counter-productive ?

Apparently ginger helps but you're not supposed to eat or drink, so ? 

For me I had nausea the first time with 5-MEO DMT. I sat up after a minute or so of plugging it. For my next trips forward, I spent the first 5 minutes or so lying down in the recovery position before sitting up when I feel ready and I never had any nausea issues when I do that.

[Psychonaut]

I am getting that I should take 80mg of 5-meo-dmt. I don't feel like it's ego or a desire to take a large amount to prove to myself something. I have previously taken 50mg. 

I am not sure what peoples doses are atm, but I mean it can't kill me, right? Well nothing that is important to begin with.

[Leo Gura]

@Psychonaut That's a lot. You could hurt yourself.

[Psychonaut]

10 minutes ago, Leo Gura said:

@Psychonaut That's a lot. You could hurt yourself.

Psychologically?

[Thought Art]

@Psychonaut physically and psychologically. Sometimes less is more. 

Edited November 27 by Thought Art

[Leo Gura]

5 hours ago, Psychonaut said:

Psychologically?

No

[Thought Art]

@Leo Gura Don’t think so?

[Psychonaut]

I ended up filling the syringe with 80mg but splitting the doses volumetrically. So first I did about 0.3ml (~20-30mg) on the peak of a high dose MXPCP trip (120mg) and then later I did the rest 0.6ml (~50-60mg). The two doses worked well.

Edited November 28 by Psychonaut

[Thought Art]

I’m still not able to understand the actual 5meodmt trip and my thoughts and feelings about it. 
 

It’s so unitary…. I guess that is non-duality. But, I can tell my rational mind and ego don’t understand it. I want to experience it with less and less resistance, less and less story telling (like, in reality it’s just infinity and I never existed) because you come down from the state. There is a lot here to explore and try to understand. I want to let go of any ideas and fantasies I have and also let go of any teachings surround the substance so I can trip with full consciousness openness. 
 

My recent trip, again has me feeling like time doesn’t exist and it’s just the infinity. It does feel like I’m in that state for a long time. But, I think I need more meditation and longer trips. 
 

I do not understand the implications of 5meodmt. I don’t understand what the trip is saying to me. 
 

It seems to be what is described as non-duality, oneness and an absolute state of consciousness. It seems like time should not exist in that state, but it does. It feels like the trip is happening for eternity but, it’s not. 
 

There is potential more and more for completely selflessness, self love, surrender and total destruction of myself as an ego. But, not destruction of myself as a perspective or set of memories at the same time. 
 

If I hadn’t have learned about infinity would I say I experience infinity? I don’t know. Would I call it God? No. It’s hard to say. It feels very final, very total. It feels like I grasp something very deep. But, I’m not sure what it is. 
 

It definitely felt like a solipsistic, absolute unitary experience in which I realized I was this thing which was the source of existence and non-existence. But, again, I is an interpretation I am sure is fake. Because, in the sober state it’s like… that makes no sense. 

Edited Thursday at 07:22 PM by Thought Art