Struggling With 5-MeO-DMT Breakthroughs Despite Very High Plugged Doses

[Enizeo]

I've reached a point in my spiritual journey where I'm sincerely questioning what the fuck is wrong.

I’ve been seriously trying to break through for a long time, and I want to give you the full picture so you can see my situation clearly.

Substance & ROA:
– 5-MeO-DMT freebase, dissolved in vinegar
– Plugged, following Leo’s plugging protocol exactly
– Same batch and method used by two of my close friends — both broke through easily
– Onset is fast (1–3 min), peak hits hard, and the entire experience fades after ~20 min
– Body load is intense, especially dry heaving, but no nausea (empty stomach)

Doses attempted:
– Past: up to 30 mg
– Current streak: 20 → 35 → 40 → 45 → 53(!) mg plugged
At these levels, I assume a breakthrough should be happening, given my friends’ results.

Phenomenology:
– Extremely heavy body load
– Very intense sensations
– Strong alteration of state
– But “I” remain coherent and do not “break through”
– After ~20 min the peak is over, then the experience fades over the next hour.

My mind during the peak:
– There is still a sense of agency
– I catch myself subtly monitoring the experience (“is it happening?”)
– When I notice this, I relax it
– No major fear during the peak (just pre-trip anxiety because high doses are uncomfortable)
– Experience is mostly abstract/intense, not visionary

My psychedelic background:
– Extensive LSD use (many trips, though not always serious)
– Mushrooms, ketamine, ayahuasca, MDMA, DXM
– I’ve had one LSD breakthrough 3 months ago that felt meaningful, although I can see that it goes a lot deeper. I became conscious of the distinction between actuality and imagination, unity, and that time/people/places are imagined — but there was a subtle sense of I throughout.
– Basically: I have never had a full ego death on any psychedelic, despite many attempts

My spiritual practice background:
– Started 10 years ago, at the age of ~18 when I found Leo
– Meditation, self-inquiry, Hatha Yoga, Kriya Yoga
– Two 10-day Vipassana retreats
– I've had many distracted periods and some periods of 1–3 months with daily practice (30–60 min)
– Read and listened to quite a lot of spiritual stuff (Ralston etc.)
– Watched all of Leo’s videos at least once
– Plenty of breathwork
– No major nondual breakthroughs outside psychedelics

My mind’s baseline nature:
– Highly conceptual, analytical, active
– I’m intelligent and curious, easily pulled into thought
– Concentration meditation has always been difficult
– My mind tracks things automatically, even when I try to relax it

My emotional orientation:
– I don’t fear the breakthrough
– My real fear is: “What if it never happens for me?”
– After 10 years of trying, I don’t know what else to do
– There’s a deep longing for Truth / God / direct realization
– I feel confused why I’m not progressing despite consistent effort and very high doses
– At this point, I'm really longing for guidance because I can't seem to proceed on my own

My question:
Given this entire picture —
why am I not breaking through, even at 45–53 mg plugged?
Is this purely psychological resistance?
Epistemic resistance?
Energetic block?
Something about my baseline consciousness?
Or something about how my mind “grips” experience even at high doses?

Any insights would be massively appreciated.

Edited 6 hours ago by Enizeo

[Leo Gura]

So, this is purely genetic.

I suggest trying other chemicals like salvia, THCA, DMT, etc.

You need some other chem.

You seem to have a pretty high tolerance. This means you need to look for chems that have low body load so you can take them in higher dose.

If LSD works for you, higher dose there might be your best bet.

Edited 5 hours ago by Leo Gura

[OBEler]

@Enizeo unfortunately you are not sensitive. My girlfriend needs 10 mg  5 Meo plugged to have a breakthrough.

I would consider to combine substances.

 

[Verg0]

Have you tried vaping the 5-MeO-DMT?