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CFS / Chronic Fatigue Syndrome

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- OpenEvidence AI

Multiple chemical sensitivity (MCS) is characterized by recurrent, multisystem symptoms triggered by low-level chemical exposures that are generally tolerated by the wider population. The evidence base for MCS includes epidemiological, clinical, neurobiological, and genetic studies, but the pathophysiology remains incompletely understood and diagnostic criteria are not universally standardized.

Epidemiological studies show that MCS is more prevalent in women, particularly in middle age, and is associated with comorbidities such as fibromyalgia, asthma, and migraine. Symptom patterns typically include hyperosmia, asthenia, dyspnea, cognitive disturbances, and neurocognitive symptoms, with airway and mucous membrane symptoms often presenting first.[1-4] The Quick Environmental Exposure and Sensitivity Inventory (QEESI) is commonly used for case identification in research and clinical settings.[2][4]

Neurobiological evidence suggests involvement of sensitization mechanisms, particularly of transient receptor potential (TRP) channels such as TRPV1 and TRPA1, and altered functioning in brain regions associated with sensory processing and affective regulation. Functional imaging and capsaicin challenge studies support these findings.[5-7] The olfactory-limbic model and neural sensitization/kindling hypotheses are prominent, positing that repeated low-level exposures may amplify central nervous system reactivity.[6-7]

Genetic studies have identified associations with variants in genes related to chemical detoxification, oxidative stress, inflammation, and neurotransmitter regulation, including the SLC gene superfamily, though findings are inconsistent and require further validation.[5][8-9] Some studies report altered antioxidant enzyme activities (e.g., catalase, glutathione-transferase) in MCS patients.[9]

Consensus statements, such as the Italian Expert Consensus, emphasize the need for standardized diagnostic and management approaches, and highlight the lack of evidence-based guidelines for treatment.[10] There is ongoing debate regarding the organic versus psychogenic origins of MCS, but recent literature increasingly supports a multifactorial, biologically plausible model involving gene-environment interactions, neuroimmune mechanisms, and psychosocial factors.[3][5][9-10]

In summary, the evidence for MCS encompasses clinical, epidemiological, neurobiological, and genetic domains, but definitive biomarkers and universally accepted diagnostic criteria remain lacking. The syndrome is best understood as a complex, multifactorial condition with both biological and psychosocial components.[1-10]

1.Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms.

Del Casale A, Ferracuti S, Mosca A, et al.

International Journal of Environmental Research and Public Health. 2020;17(18):E6551. doi:10.3390/ijerph17186551.

2.Multiple Chemical Sensitivity Syndrome: First Symptoms and Evolution of the Clinical Picture: Case-Control Study/­Epidemiological Case-Control Study.

Fares-Medina S, Díaz-Caro I, García-Montes R, Corral-Liria I, García-Gómez-Heras S.

International Journal of Environmental Research and Public Health. 2022;19(23):15891. doi:10.3390/ijerph192315891.

3.Multiple Chemical Sensitivity Described in the Danish General Population: Cohort Characteristics and the Importance of Screening for Functional Somatic Syndrome Comorbidity-the DanFunD Study.

Dantoft TM, Nordin S, Andersson L, et al.

PloS One. 2021;16(2):e0246461. doi:10.1371/journal.pone.0246461.

4.Multiple Chemical Sensitivity in Patients Exposed to Moisture Damage at Work and in General Working-Age Population-the SAMDAW Study.

Nynäs P, Vilpas S, Kankare E, et al.

International Journal of Environmental Research and Public Health. 2021;18(23):12296. doi:10.3390/ijerph182312296.

5.Multiple Chemical Sensitivity: It's Time to Catch Up to the Science.

Molot J, Sears M, Anisman H.

Neuroscience and Biobehavioral Reviews. 2023;151:105227. doi:10.1016/j.neubiorev.2023.105227.

 Leading Journal 

6.An Olfactory-Limbic Model of Multiple Chemical Sensitivity Syndrome: Possible Relationships to Kindling and Affective Spectrum Disorders.

Bell IR, Miller CS, Schwartz GE.

Biological Psychiatry. 1992;32(3):218-42. doi:10.1016/0006-3223(92)90105-9.

7.Individual Differences in Neural Sensitization and the Role of Context in Illness From Low-Level Environmental Chemical Exposures.

Bell IR, Schwartz GE, Baldwin CM, et al.

Environmental Health Perspectives. 1997;105 Suppl 2:457-66. doi:10.1289/ehp.97105s2457.

8.Multiple Chemical Sensitivity and the SLC Gene Superfamily: A Case-Control Study.

Alcorta E, Gomez-Diaz C.

International Journal of Molecular Sciences. 2025;26(13):6484. doi:10.3390/ijms26136484.

 New Research

9.The Search for Reliable Biomarkers of Disease in Multiple Chemical Sensitivity and Other Environmental Intolerances.

De Luca C, Raskovic D, Pacifico V, Thai JC, Korkina L.

International Journal of Environmental Research and Public Health. 2011;8(7):2770-97. doi:10.3390/ijerph8072770.

10.Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).

Damiani G, Alessandrini M, Caccamo D, et al.

International Journal of Environmental Research and Public Health. 2021;18(21):11294. doi:10.3390/ijerph182111294.


How is this post just me acting out my ego in the usual ways? Is this post just me venting and justifying my selfishness? Are the things you are posting in alignment with principles of higher consciousness and higher stages of ego development? Are you acting in a mature or immature way? Are you being selfish or selfless in your communication? Are you acting like a monkey or like a God-like being?

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On 9/7/2025 at 4:14 PM, Charlotte said:

ME/CFS

ME/CFS is a general diagnosis -> MCS is the cause.

What causes CFS is hormonal problems, hormones being blocked by air born chemicals (MCS). 


How is this post just me acting out my ego in the usual ways? Is this post just me venting and justifying my selfishness? Are the things you are posting in alignment with principles of higher consciousness and higher stages of ego development? Are you acting in a mature or immature way? Are you being selfish or selfless in your communication? Are you acting like a monkey or like a God-like being?

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5 hours ago, Charlotte said:

@integral is this your own opinion or evidence based? 

I will answer yes to that epistemically loaded question. lol

Besides the mountain of Scientific evidence that all of these chemicals block hormones and cause every disease known to man, a more important way to figure out what is true is with careful observation, and experimentation.

Edited by integral

How is this post just me acting out my ego in the usual ways? Is this post just me venting and justifying my selfishness? Are the things you are posting in alignment with principles of higher consciousness and higher stages of ego development? Are you acting in a mature or immature way? Are you being selfish or selfless in your communication? Are you acting like a monkey or like a God-like being?

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On 9/24/2025 at 5:10 PM, Charlotte said:

@integral is this your own opinion or evidence based? 

https://aseq-ehaq.ca/en/events/ join these events, the latest zoom meeting spoke about the 3 major disease cause by home air-born chemicals, Chronic fatigue was one of them. All evidence based.

aseq-ehaq is the organization working towards a solution. If you have chronic fatigue its vital to attend and learn about this, its the main cause. 


How is this post just me acting out my ego in the usual ways? Is this post just me venting and justifying my selfishness? Are the things you are posting in alignment with principles of higher consciousness and higher stages of ego development? Are you acting in a mature or immature way? Are you being selfish or selfless in your communication? Are you acting like a monkey or like a God-like being?

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@integral have you extended your research to include animals yet? 

Dogs and cats are displaying ridiculous amounts of health issues and cancer - rates and incidents have been on the rise. I thought it prudent to point this out as their bodies are much smaller than us, and reach toxic capacities much much quicker. 

The vet that I take my dog to researches this on the side.

I haven't contributed much to your conversation but I have been reading what you present 👍


Deal with the issue now, on your terms, in your control. Or the issue will deal with you, in ways you won't appreciate, and cannot control.

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32 minutes ago, Natasha Tori Maru said:

@integral have you extended your research to include animals yet? 

Dogs and cats are displaying ridiculous amounts of health issues and cancer - rates and incidents have been on the rise. I thought it prudent to point this out as their bodies are much smaller than us, and reach toxic capacities much much quicker. 

The vet that I take my dog to researches this on the side.

I haven't contributed much to your conversation but I have been reading what you present 👍

Very true, the main focus with my dog has been allergies, she slowly became allergic to dog food overtime and I carefully experimented until we found one that didn't cause these issues. Then she would relapse over and over again and we'd have to constantly change her food to avoid these allergies. The biggest problem is when she has an episode her skin would change colour and her hair would go white super fast. She deteriorate much faster than a human would.

But the main insight I got from this after years of experimentation is that most dogs are ageing prematurely, deteriorating and have mood problems because they're allergic to what they're eating and their owners don't notice.

A dog should never scratch. This is the key thing people don't realize. When you scratch your dog with your hand and then they do that thing where they jiggle their foot because they're stimulated this is actually a sign of an allergy and their skin is super sensitive.

It's cute when we scratched their belly and then they shake their foot to mimic it, but this is actually a sign of a skin sensitivity because there allergic to the food they're eating.

And so this causes them to age much faster and have a bunch of health problems while the owners and the veterinarians have really no idea what's going on. They associate everything with aging, "its just aging". They're not seeing the slow accumulated damage from these allergies.

---

The second major event and you see this on TikTok is when they say "no one tells you how fast they deteriorate", and what they mean by this is that the dogs at a certain age would quickly fall apart and get old. Their hair will turn white quickly not gradually.

The insight here is that when their bodies reach a certain point that they can't tolerate the allergy anymore their hair will immediately turn white and there skin will dis-colour and they're gonna show mood problems like low energy, they will also start to show large "bumbs" all over there body and thats a sign there close to death.

The only solution when a dog reaches these later stages is that you have to remove the allergy and they need a lot of intensive exercise.

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Also, I have never seen a single pet survived chemotherapy... I have no idea why veterinarians even bother going that direction because the survival rate is near zero. They're better off doing anything else. Their bodies are too small and sensitive and they deteriorate and change 100x faster than humans do.

And don't get me started on neutering... This is just a marketing scam. It makes no sense to remove vital hormone producing organs from an animal.

Neutering causes hormonal problems that can lead to depression or anxiety and mood problems and a bunch of other issues for the animal. It has to be completely avoided.

If you remove the testicles of a male human, they will have chronic depression and they need testosterone replacement therapy for the rest of the of their lives. For some reason veterinarians just bought into this ridiculous idea that this doesn't apply to animals?

31 minutes ago, Natasha Tori Maru said:

The vet that I take my dog to researches this on the side.

That's very impressive because most veterinarians do not live a life of learning and are simply repeating whatever the pharmaceutical companies have outlined for them because they don't realize the corruption in their education system.

Edited by integral

How is this post just me acting out my ego in the usual ways? Is this post just me venting and justifying my selfishness? Are the things you are posting in alignment with principles of higher consciousness and higher stages of ego development? Are you acting in a mature or immature way? Are you being selfish or selfless in your communication? Are you acting like a monkey or like a God-like being?

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@integral thanks for the insights ❤️

My girl hasn't been neutered. I just deal with her cycles and it's not an issue. I learned to manage like any other part of life. And IT IS life. She is not here at my convenience. I too am worried about having her fixed. It doesn't make sense removing an essential part of them, although I face a lot of judgement for not fixing her. I am consistently accused of being a bad pet owner.

I cook all her food. It did a lot of research around what dogs can eat and cannot before I begun... But I noticed her digestion prior any allergies or skin issues. She hasn't had anything like that thankfully. But my vet has spoken about terrible bumps, skin rashes, eye issues. Scratching. Cancer/immune issues. She is very intelligent, but also burdened with what she sees owners do. Most dogs are really overweight as well.

My girl doesn't have any sort of twitching or scratching as per your elaboration above. She is a poodle so prone to ear infections (floppy ears) - but I noticed when I begun cooking all her food her earwax buildup went down. No issues at all there. 

One of the biggest things I did note was her behaviour and training improved as soon as I changed her diet. Her anxiety went down, less destructiveness, more receptive to training. More attentive and better interactions with strange dogs. 

I do not use any scented products in my apartment either. I get a blocked/stuffy nose if I use anything of the sort. I am hyper aware of this as dogs smell on a level we could never understand. It's a pain in the arse cosmetics wise for me 🤪. I've almost eliminated everything because there are scents and additives I cannot be sure of. 

I'll keep observing 


Deal with the issue now, on your terms, in your control. Or the issue will deal with you, in ways you won't appreciate, and cannot control.

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@Natasha Tori Maru Your a fantastic pet owner! You're going above and beyond what any normal person would do.

I'm curious of what kind of meal prep are you doing?  


How is this post just me acting out my ego in the usual ways? Is this post just me venting and justifying my selfishness? Are the things you are posting in alignment with principles of higher consciousness and higher stages of ego development? Are you acting in a mature or immature way? Are you being selfish or selfless in your communication? Are you acting like a monkey or like a God-like being?

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