Michael569

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Posts posted by Michael569

  1. Posted

    8 hours ago, integral said:

    Linking a study is like linking a verse in the bible. 

    yes and no. 

    YES - in a sense if you remain a dogmatic sheep , close-minded to alternative opinions because "the study says so" especially in topics where the evidence quality & quantity is generally low and deficient

    NO - if you have an overall direction of the evidence accumulated over decades (for example things like saturated fats and heart disease, saffron and depression, weight loss and diabetes) where you have different trials and studies and meta-analyses all pointing roughly similar way over the years) - in such case, you can almost be sure that sticking to what those studies say is likely to be a better choice than the alternative. It is never 100% and there are always outliers to who the opposite seems to be valid.  But overall, when the evidence quality is high and abundant, you are most likely to benefit by following that line of direction....at least where health is concerned. 

    One shouldn't read research as one would read a bible - it is yet another tool in your arsenal when you are a clinician or a practitioner or simply a health seeker. It is certainly not the only one. 

  2. Posted · Edited by Michael569

    3 hours ago, integral said:

    statin.png

    The video covered it. With most of these studies they show a risk reduction in one decease like coronary heart disease vs placebo group but both groups had a similar risk of death from all causes. Meaning it did not improve the quality of there life or health, they avoided one disease and suffered another. 

    I am not an expert in statistical methods by any stretch and would not presume any expertise here, however I believe the JAMA review has been coming under a lot of scrutiny and criticism the way they presented their data and for sorta under-evaluating the ARR and and that mean trial durations were relatively low,  this is a common issue in CVD prevention trials, if the study is too short, too few people experience the event and your risk ratio is skewed (as dark as that sounds) 

    ARR in general is a relatively low number because you are taking the risk reduction ratio of two different groups and dividing the risk so even very small ARR are very much clinically meaningful. So even if the prevalence is very high (e.g. a lot of people in your cohorts are sick) ARR may remain low - @undeatheris that so or am I talking out of my ass here? :D 

    This was a good debate that went deep into this one for anyone interested in geeking out 

     

  3. Posted

    20 hours ago, Juan said:

    I guess nowadays I’m very conscious that this is a death animal, when I smell now the eggs or any meat, the smells makes me aware that this is something dead, idk if anyone else experienced this, @Michael56

    I used to have this during my times on a vegan diet as well, yah. It is probably connected to deeper belief systems rather than any form of biological inheritance or anything to do with ancestral diets. If you subconsciously believe that animal products are bad for you, I wouldn't be surprised if they suddenly start becoming gross to look at. Probably one of millions of adaptations we go through all the time. 

  4. Posted

    On 06/05/2023 at 7:23 AM, StarStruck said:

    If I stop eating red meat, I feel like a zombie.

    Sounds like it's either a deficiency issue or an insufficient replacement issue. 

    If you replace the nutrient density of that steak with a bowl or rice you'll probably feel like shit, whereas replacing it with equally caloric and nutrient-dense food, you'd probably be fine. 

     

     

  5. Posted · Edited by Michael569

    4 hours ago, integral said:

    I don't believe you. I think your focused on being right and that's more important then the truth. 

    While this conversation is none of my business, I can attest that I've consulted a few very difficult client cases with @undeather through PMs over the last 2 years, and his advice has helped me prepare better plans, request better tests and generally help a few complex clients on a better scale. Take that testimonial for whatever it's worth; personally, I'm grateful to have someone like that around here, considering he is sharing high-quality advice for free and considering a lot of health information being exchanged around here is going beyond common quackery.  There wasn't any external agenda included, he never asked any money, nor to send him patients nor for a review or anything like that in exchange and he doesn't even have a website in his signature so not sure what the ultimate goal would be. 

    I think we have to recognise the limitations of our knowledge and be humble enough when presented with the opportunity of further learning or with the opportunity to correct our worldview. Especially where public health is concerned. 

  7. Posted

    1 hour ago, The Caretaker said:

    Also, do you have any inputs on those parts?

    On 06/05/2023 at 8:56 PM, The Caretaker said:
    • If I take all the supps above at once, will they get fully absorbed?
    • Creatine is recommended to take with something sweet (like juice or sweetened milk) for better absorption. Is this true?
    • My B comlex it's very concentrated, up to the point where my piss becomes saturated yellow for half of the day. However, today I took all my supps with juice (including vitamin B) and my urine was the normal color. + it's overall "dangerous" to take such a high dosage of B vitamins?

    yeah, cross-supplementation of those shouldn't impact absorption. Yellow urine from B vitamins is normal and benign. Not sure about creatine absorption, but I probably wouldn't worry about it. 

    That B12 is something you need to focus on with priority. 

    First of all just get it retested in some time and see what the trend is. In addition, figure out if you can find the MMA test, 

    If the B12 keeps coming low even after supplementation,  it may be an absorption issue at which case they need to dig deeper and run maybe the following panel to if there isn't an issue at the level of the stomach lining or proximal intestine. Your doctor can run numerous tests such as the below to test for those: 

    • intrinsic factor antibodies test 
    • parietal cell antibodies test 
    • gastrin test 

    In addition, I would potentially even consider Coeliac testing if nothing else comes up. 

     

  8. Posted · Edited by Michael569

    You could try a sublingual B12 drops, 1000 mcg for a month then test again (withdraw the supplement 48 hrs before the test)  for better absorption, and hold it under the tongue for a minute - that method of administration is similar to intravenous application 

    In terms of testing, consider getting a tissue B12 assessment - look up a private test called "Methylmalonic Acid", you want your results of MMA to be as low as possible. It will be a bit more expensive than serum B12 and unlikely to be done by doctor so you need to go private. 

  9. Posted · Edited by Michael569

    Daily Mail? :D - the publishers whose sole desire is to push people's emotional buttons. The crap they release here in UK on daily basis is something stunning. 

    Read the whole paper then see if your statements still holds https://www.fao.org/3/cc3912en/cc3912en.pdf

    Btw noticed what they did here: 

    Evidence suggests that in adults, yoghurt and milk consumption reduces the risk of all-cause death, high blood pressure, stroke, type 2 diabetes, colorectal and breast cancer and osteoporosis, the report states - the osteoporosis link is inconclusive, adults and older adults consuming highest amount of milk are not the most protected from osteoporosis, that line of evidence is all over the place. There is also a threshold effect with dairy where it doesn't cross 35g of saturated fat per day after which risk margins increase. 

    Leading cardiologists rank the 10 most popular diets in terms of heart health (look away now, vegans!)  - "leading cardiologist" - expert reviews lie at the bottom of the hierarchy of evidence, who cares what they say when what they say contradicts the direction of the evidence. In addition, the cardiologist is a clinician, not a researcher and while some MDs go between academia & practice, professionally most stick to one or the other - or is that not so @undeather? 

    The report also found there was relatively solid evidence that egg consumption does not increase the risk of stroke or heart disease. - this part is true, but conveniently they leave out breast cancer risk or the 47% rise in ovarian cancer risk for each 5 egg set consumed per week. 

    Meanwhile, milk and dairy consumption during pregnancy promotes a healthy birth weight of the baby, evidence shows - and promotes prostate cancer risk in men past 50 as well as breast cancer in women past 50, especially whole milk products. 

    And beef consumption was found to improve cognitive outcomes and protect against iron deficiency - which can cause dizziness, fatigue, headaches, an irregular heartbeat and pale skin. The report states that eating 72g of beef each day is safe. Notice how they omit the fact that red meat is associated with an increased risk of bowel cancer and coronary heart disease and nitpick that it "improves cognitive outcome"...what the heck Daily Mail, 

    What about processed meat? A lot of people will misunderstand the 72 gram recommendation as freedom to eat processed beef and bacon. 

    What about high fat vs low-fat dairy? 

    What about animal fats used for frying? 

    What about butter? 

    They basically left out all the negative aspects of animal-based diets and nitpicked whatever evidence there was to be found in their favour. 

    I don't know who wrote this piece of cherry-picked garbage but if they do this, they should have gone all the way, this is a very one-sided review. They did not mention any of the benefits of plant-heavy diets, which there are many. 

     

    You can do better @StarStruck but I understand your desire to rock the boat with your posts ;) 

  10. Posted · Edited by Michael569

    On 04/05/2023 at 11:43 AM, M A J I said:

    All the great masters and yogis knew and taught this and many of the longest living people lived off wild-fruit/plants

    this might be a geographically biased report but I've had the pleasure to speak to about 5 Yogis in different temples across Norther and Southern Thailand and Vietnam last October and November. They ate one a day and probably similar to what you described. What I saw was - tooth loss, extreme signs of ageing, joint problems (limping and needing a cane), bad mouth odour, and extremely poor level of arm, shoulder and chest muscle development. Most likely there was also osteopenia and even full blown osteoporosis , that wouldn't surprise me. They looked weathered, tired and weak. 

    They were highly intelligent people, no doubt about that, but their bodies looked starved and malnourished to a point of collapse. I don't know where the people you described live but they don't seem to be found in South-East Asia which is one of the largest regions in the world where you will find real Budhist monks & yogis living of raw foods, eating once a day. Like, there are monks there who live alone, meditate in caves (that have living snakes) eat fruit and raw diets and they look half-dead and starved.

    I would assume Chinese or Indian monks to look very similar but I have no direct experience with speaking to those. 

    Dunno man, something's wrong with that line of reasoning. Once you travel the world a bit, a lot of these internet arguments start dying out. If you are in a privileged position in life (living in a wealthy country/wealthy background) you may be missing that. 

     

     

  11. Posted

    13 hours ago, Jannes said:

    100g of uncooked legumes,

    are you relying mostly on legumes for protein? Just curious as in total that would get you only about 8-12 grams from a 100g cooked (a little bit more from 100g raw). 

    13 hours ago, Jannes said:

    I heard that certain spices can actually reduce bloating though. 

    possibly, never looked into that literature but I'd have no problem believing that 

    13 hours ago, Jannes said:

    Do you think its possible to create a supplement which reduces bloating by neutralizing these bacteria which cause gas?

    That would be a bestseller wouldn't it :D "a pill to keep the farts away"

    13 hours ago, Jannes said:

    Oats are as beneficial as legumes?? 

    no I meant oats compared to other wholegrains 

  13. Posted · Edited by Michael569

    11 hours ago, Jannes said:

    Thats actually more of a counter argument for me for eating these foods because I like to minimize my fiber intake on all sides around legumes so that I can eat the most legumes (protein) possible without bloating, gas etc. but I do like the taste of whole grains sometimes. They tase really "healthy" to me. 

    They are unlikely to cause more bloating than legumes if you cook them properly, I've never experienced bloating from something like spelt or barley. On the bloating side, the way I see it is that it gradually improves, it's a stage of adaptation. I don't think a benign bloating is harmful, in fact based on some preliminary work done by the Sonnenburg Lab, different colonic bacteria expell different gases which then other species can take in for nourishment, some of it we fart out, some of it stays in and enriches the environment......so maybe a little bit of bloating is a small "fee" we pay for the fact that or protection against things like colorectal cancer goes through the roof.  Considering it is a number one cancer in the world, that is a trade off I am happy to make anytime. 

    Not to mention the fact that you are flooding your body with so many SCFAs from the fibre metabolism by your microbiome - although we don't understand the full implication of SCFAs yet, it is likely to be highly beneficial especially where immune system, heart and brain are concerned, personally I also think autoimmunity, blood-brain barrier and cognitive performance are highly implicated there.and people who struggle with those inb some shape or form need to fix their gut before they fix the end point...anyways that's a bit of geeky speculation you didn't ask for . 

    Up to you of course, this was merely a suggestion for you guys who want to try something different. Oats are likely to be as beneficial

  14. Posted

    15 hours ago, integral said:

    I didnt expect you to be the party till you drop kind of guy. ?

    I'm not which is why it messed me up so bad :D:D

    It was one of those "you just have to mate" moments that I came to regret later 

    15 hours ago, integral said:

    'm looking for that enlightenment pill. That treasure could be found in some where related to why some bodies are more sensitive to others.

    Why haven't we figured out the right drugs that will turn off the sympathetic system with out any side effects, in a way that works 100% with all the moving parts of the bodies complexity. 

    These got to be a new time of drug revolution that intelligently works 100% with all the complexity in the system. 

    can't help you there mate but I'm sure there are folks around here who might be able to 

  15. Posted · Edited by Michael569

    50 minutes ago, integral said:

    Like any kind of stimulant if it where visual like a video game or watching a movie would send my heart pounding, cant breath...this is highly abnormal for my personality, its my body do to extreme sleep deprivation and other factors was under so much stress that a feather would push it over the limit, If i had a negative thought it would send me into a full body spasm and seizure, just 1 negative thought. I was at the limit of my stress meter. A hyper sensitive state and the b-complex pushed it higher.

    yeah, that's a possibility. I've definitely experienced something similar after a few days of sleep deprivation, a bad diet and drinking alcohol for a few days in a row (during my mate's stag party in Greece) - I came to a tipping point and then all it took was a shot of espresso and I got a full blown panic attack that lasted for 2 days and the fallout of which lasted another 2 weeks. 

    So it might mean there is already too much underlining tension in body / environment and it takes very little for the cup of "emotional tolerance" to overflow. I also think that some people are more resilient again mental distress than others. The earlier are people who need to always be careful with how much they put on their plate (emotionally speaking) and need to frequently lay low to recover. The other group are folks who can devastate their body endlessly with smoking, alcohol, steroids, meat heavy diets burning the candle from both ends while being at the peak of their strength and vigour until one day they get a sudden stroke and die before the ambulance comes in in their mid 50s. I have a close mate who is going that way and I fear for his family 15 yrs from now. 

  16. Posted · Edited by Michael569

    22 minutes ago, Schizophonia said:

    "b-complex is highly stimulatory on the system so your not simply pee in out, its first effecting you. So if you give a b-complex to someone with anxiety and sleeping issues you make the situation worse, they never figure out this "harnessless" vitamin supplement made it worse and they experience hell for a while"

    I argue that it is in fact often the opposite.
    Pure Encapsulation's b-complex sedates me and helps me sleep/relax, probably because of the niacin

    I think you're both right to a degree but it might just be more complicated than A or B. 

    Certain mental health issues have indeed been associated with B-deficiency and giving people B-complex might help (if that was the causative factor) although the data is inconclusive as you may see. Forest Plots are borderline statistically significant and confidence intervals remain fairly wide which tells you there is more to it (as it always is) 

    On the other hand, some people do indeed find them energising. B-vitamins are a part of the glycolysis & Kreb Cycle that help your body produce ATP (energy currency) so technically if you were long-term deficient and suddenly you get an influx of B-s in a way you are getting "back on the baseline" but for anyone long term deprived this may come across as "highly stimulating" because they've just been deficient for so long they forgot what it feels like to have energy (this is actually pretty common among guys, I've seen a  fair share of that in my practice) 

    In addition, B vitamins are cofactors in all sorts of metabolic processes including things like neurotransmitters and even certain hormones so in a way, you might just be getting back to "feeling normal". 

    And finally, B vitamins are notoriously difficult to measure because they do not hang around for too long (with exception of B12) and so most standardised blood tests are inaccurate and specific essays such as EGOT, MMA or Red Blood Cell Folate need to be acquired for an adequate tissue representation. As an example, a person who just took B12 supplement would show "normal" on Serum B12 but would show high on Methylmalonic Acid test indicating that in reality their tissue levels are depleted but the blood test only saw the circulating supplement so we can't really tell if we are looking at the right thing to begin with 

    From experience with client work, on their own, they rarely do much if not part of a larger dietary/lifestyle modification and at that point we no longer know what made the difference anymore (the major challenge with epidemiology) 

    But then who knows, there is still much we don't understand :)

     

  17. Posted · Edited by Michael569

    @Jannes when I use them for breakfast it is the same recipe as when making oatmeal (just takes longer to cook) something like the breakfast recipes in this videl I made ages ago.

    When using as a main, then it depends - but yet spices are usually added depending on what meal is it (Mexican, Indian, Lebanese etc..) think of them as a rice alternative and use them as such. 

    They change the taste slightly but considering these things have about 10-15 times as much fibre as white rice, I don't mind. 

  18. Posted · Edited by Michael569

    @integral I order these online in bulk and then mix and match in a jar. 

    I usually do

    • Barley
    • Buckwheat
    • Spelt (for some reason it is more expensive than all the other ones)
    • Wheat Grain
    • Sometimes amaranth or quinoa

    If you can order these in bulk, that's gonna be cheaper. I do 2 kilos of each about every 4-6 months

    Then i just throw in a cup in boiling water and once ready top up with whatever I have available. 

  20. Posted

    About 21 - 23 once the epiphyseal plats calcify fully, then your height is set for life . After that, any growth you get is tissue density only (muscle, fat, bone-to a small degree) 

    Sometimes if people have deformities of spine like lordosis and can have them corrected, they may get a few cm back but not sure how common that is and probably irrelevant to healthy people. 

    You get growth hormone spikes throughout your whole lifetime, but its impact diminishes over a time. 

  21. Posted · Edited by Michael569

    12 hours ago, Someone here said:

    s gonna be raw fruits and vegetables. That's it. So if you're really interested in cleaning up your diet and eating healthy.. The only thing you should put in your body is a peice of fruit or a vegetable. Nothing else. That's the healthiest and cleanest diet possible. 

    Give it a try, go raw for 3 months then come back to use and make a long-educated post about it. Otherwise, these sorts of absolute statements are hollow and meaningless. If we are going to be ignoring the current level of evidence (which disagrees with you) then the only thing left is direct experience. 

     As they say, "direct experience is the king". Would love to see the results of that journey. Heck....document it and then make YouTube video. 

  22. Posted · Edited by Michael569

    11 minutes ago, Asayake said:

    Perhaps you ate too little calories because vegan foods tends to be less calorically dense

    agreed with this, sounds like a half-arsed vegan diet @integral bro :D I don't think you tried hard enough. 

    I am no longer vegan but when I was for 4 years, the first few months until I figured out how to do it properly I was like Walking Dead, then my energy came back and afterwards everything was as it was previously, digestive regularity was definitely better. 

  23. Posted · Edited by Michael569

    Did you test this yourself or the doctor? Have you fasted for 12 hours before the test? 

    You need re-testing and also need to get your long-term blood sugar control testing (HbA1C & HOMA-IR) 

    How are your blood lipids? (cholesterol, triglycerides etc). What is your BMI? 

    Basically go back to a doctor and ask for retesting. No doctor in the world would just leave this without testing further in a 27 year old persom. 

     

    Could there have been some sample contamination? When I was a kid, my mom had me pee in a jar that previously had honey in it and it was poorly washed and once the doctor tested she called my mom saying I have the most extreme diabetes she has ever seen. Ofcourse the dissolved honey in the sample did not help :D 

  25. Posted

    16 hours ago, undeather said:

    What do you mean with pharmacodynamic life? Half life? Pharmakokinetics? Dose-response?

    sorry, I meant half-life 

    16 hours ago, undeather said:

    As you know, ApoB particle quality & quantity is the single most important factor in atherogenesis from a lipid-perspective.

    Yes, I'm slowly beginning to realise this. if a patient comes to you with elevated LDL -C and elevated non-HDL, cholesterol, how do you tell if they would benefit from ApoB testing as well? Age? Ethnicity? Other risk factors? (alcohol, smoking) 

    16 hours ago, undeather said:

    Lp(a) expression is mostly genetic - in fact, its the most prevalent genetic lipid abnormality and also mostly overlooked.
    Almost 20% run around with high Lp(a) and dont know it. Its super atherogenic and increases CVD risk substentially. 
    If I got a patient with high ApoB & high Lp(a), then I know its time to agressively lower his ApoB burden. 
    Lp(a) lowering is difficult - Statins won't do it - PCSK9-inhibitors will do it by about 25%. New drugs which look promising are in development. 
    Lp(a) doesn't respond to diet, but ApoB does - people with high Lp(a) just need to look at their other risk factors more clearly. 

    does LP(a) change over lifetime or is it moslty set like APoE4, if you have it, you have higher odds of ending up really fucked if you are not careful.