Not just the ground of reality, but all of reality.
Not all questions. But many.
Many questions are poorly formed or simply irrelevant.
Well, that's something you could inquire into. Whether you will ever get an answer is unclear.
Any psychedelics could potentially do it. 5-MeO and DMT are of course two of the most powerful ones and have a good chance to give you more insight into the ultimate nature of reality.
By the time you reach the necessary level of liberation you will no longer exist as a human self.
So it's a bit like curing cancer by shooting yourself in the head.
To keep you alive.