orally active 5meodmt and dmt without maoi?

[Fluran]

https://www.businesswire.com/news/home/20231208385528/en/Terran-Biosciences-Receives-Notice-of-Allowance-for-Four-US-Patents-Including-for-the-World’s-First-New-Salts-and-Polymorphs-of-Psilocybin-potentially-enabling-future-505-b-2-pathway

a biotech platform company developing therapeutics and technologies for patients with neuropsychiatric illnesses, has received notice of allowance from the United States Patent and Trademark Office (USPTO) for four US patents covering a number of breakthroughs in the psychedelic therapeutic space.

Two of these patents cover the world’s first new forms of psilocybin (psilocybin HCl and psilocybin edisylate) and their method of use in treating neurological and psychiatric disorders, including depression. The clinical trials of psilocybin to date have been limited to using the older forms of zwitterionic psilocybin described in the historical literature.

Terran plans to use its new forms of psilocybin to pursue a rapid 505(b)(2) FDA approval pathway if one of the existing forms of psilocybin currently in clinical trials is approved. This regulatory pathway could potentially enable Terran to use pharmacokinetic bridging studies and leverage existing safety and efficacy data from completed trials to bring a Terran psilocybin product to market approximately five years after the first psilocybin approval.

“With these allowances of our novel forms of psilocybin, and GMP manufacturing already completed, Terran is moving quickly toward the goal of providing patients with affordable and accessible psilocybin treatment options,” said Dr. Sam Clark, Terran’s founder and CEO. “Additionally, with the allowance of our breakthroughs in the chemistry of DMT and 5-MeO-DMT, we hope to deliver oral versions of these therapeutics, which we believe will provide the best use profile for patients.”

Terran also received a notice of allowance for a patent covering the world’s first orally active prodrugs of DMT and 5-MeO-DMT. DMT is a psychedelic compound that is not orally active unless taken in combination with a monoamine oxidase inhibitor (MAOI) to help reduce metabolic breakdown. However, this combination approach is difficult to translate to widespread clinical use as it can be associated with side effects such as nausea, vomiting, and changes in blood pressure [1,2]. Terran’s new patent-protected prodrugs were designed to avoid this metabolic breakdown and to be given as a single oral dose without the need for combination with an MAOI.

Terran plans to leverage the 505(b)(2) pathway to bring an oral DMT product and an oral 5-MeO-DMT product to the market after the FDA approval of an alternative form of the historical compound (e.g., injectable, inhaled, or buccal forms), which are in trials now.

Additionally, Terran is developing ibogaine derivatives and has received a notice of allowance on a novel form of tabernanthalog monofumarate and the method of use for treating neurological and psychiatric disorders. Terran believes this new discovery may be the most stable form of tabernanthalog monofumarate.

ABOUT TERRAN BIOSCIENCES

[Thought Art]

Just, don’t mix 5meo with an MAOI

[Leo Gura]

A solution for a problem that does not exist.

You don't need a special form of DMT or 5-MeO-DMT. DMT is perfectly orally active with 1 pill of harmala extract. And 5-MeO-DMT should just be plugged.

These companies are looking to invent patented psychedelics so they can charge $1000s for a single dose. It's the ultimate grift.

Edited December 21, 2023 by Leo Gura

[Girzo]

Actually, in a medical setting all psychedelics that can't be eaten should just be injected, it's a more solid way than administering drugs per rectum. Also, everything that usually gets vaped should be injected, because vaping is a little bit harmful.

It is a grift, but not always only for money. Those companies also try to jump hoops around the anti-narcotic law.

This one is a funny example FT-104 (4-glutaryloxy-N,N-diisopropyltryptamine), which is basically 4-HO-DiPT (4-hydroxy-N,N-diisopropyltryptamine), but the company behind is playing dumb so hard claiming it's new drug, to bypass the law.

The big glutaryloxy part gets cleaved in the stomach or blood stream and becomes the drug on the right, which is a well-known psilocin homologue - 4-HO-DiPT

 

[Thought Art]

@Girzo How it that a “should”?

[Girzo]

@Thought Art if it's better then it should. In a hospital or at a therapy where you pay there's no need to compromise and use inferior methods people use at home.