Depression can be triggered or cure it depending on how you frame the trip and all the insights from it. Also, Depression IS NOT Genetic, only the predisposition/tendency to suffer from that particular condition is.
Try 2g of Shrooms, then 3, then 4 and so on till you get your first breakthrough experience, then move to NN DMT and LSD. Once you have experienced a couple of strong Ego Death experiences and you are not afraid of it, go for 5-meo
I find that its something like:
I love myself and i love it so much that i will make the effort to improve and become the best possible version doing what it takes
Its like if you dont love yourself you will feel that make any kind of improvenent its pointless becouse you are doing for someone that you hate(yourself)