The 5-MeO-DMT Mega-Thread

[Leo Gura]

14 minutes ago, Nemra said:

@Leo Gura, ok.

I thought you were comparing freebase with HCL of 5-MeO-DMT regarding plugging.

They plug equally well.

[LambdaDelta]

On 11/19/2025 at 2:39 PM, Leo Gura said:

If you have the option to buy freebase or HCl, buy freebase. It is 10-20% more potent per gram, and it vapes well, and it plugs well. So this covers every use case.

The only point of salts is if you are going to IV it.

If you buy the salt, you will be limited in your ability to vape it, which is not ideal. You want that option.

Agree to disagree, I'll just present an alternative viewpoint. This on its own is myopic.

Sure, going by straight molar mass freebase is 17% more potent and therefore cost-effective. But what about loss during vaping? It decreases with refined technique and better equipment, but present nonetheless. A person just starting out is guaranteed to waste a bunch. There's degradation too, even though 5MD isn't nearly as bad as N,N-DMT in this aspect, it's still a factor, while any salt will outlive you with half-decent storage. And when making it available for rectal, especially with a kitchen tier tek like vinegar, you simply cannot guarantee that every molecule of 5MD will bond to an acetic acid one, so some are left out. 'Dissolve' isn't even the right term here unless you massively oversimplify. You are forming 5MD acetate, which then becomes water soluble, but with a bunch of excess acid, hence the sting. 
Converting from salt to freebase is both less technically involved, and far more forgiving if done lousily.
Lastly, salts tend to carry less impurities. You won't see this on a regular NMR, something more detailed like LCMS + GC is required.

In the end, why not get half-half of each, or whatever other ratio you think will suit your use.
Works both ways, if you want the option to vape, you also want the option to IM/IV. It ain't 'every use case' when 2/4 of potential ROAs are left out.

What's even the reason to 'suck it up' when you're about to enter a powerful trip, besides saving a few bucks and acting tough? You want as few distractions as possible. Similarly you wouldn't want to taste Salvia's awful harshness right before getting blasted into insanity consciousness.

[LambdaDelta]

It's so fascinating. You moved on from mushrooms to 4-AcO-DMT. From insufflation to rectal. From pipes to e-mesh. From Salvia to Salvinorin A. 

In the conformity video you have a full section on psychedelic conformity and how you were able to get qualitatively different results by being open to new technology, with the example of Ayahuasca vs. synthetic N,N-DMT. We're on the same page regarding how weed is pure stupidity next to THCA.

Yet there's a few areas where you still insist on using the same techniques you were back in 2018, maybe with a few tweaks. Like microscoops instead of volumetric dosing, or plugging instead of IM. Or this vinegar stuff. It's all good if you've tested every method and settled on the ones that are most effective and convenient for you, perhaps that is the case. But you speak as though no alternatives exist and these are the definitive methods, when in fact they may not necessarily be so for others, nor are they the most precise and rigorous. I know there's not enough time in the world to give every fine detail, especially many times over, but more nuance would be nice since most people take everything at face value.

It appears that conformity is not purely a collective phenomenon, it also exists as attachment to ideas and methods one has personally derived, and it is especially difficult to notice and escape when those actually work and are superior to whatever was out there at the time.