The 5-MeO-DMT Mega-Thread

[Goodpeace]

On 7/14/2025 at 3:49 AM, Leo Gura said:

@Goodpeace About 10mg

Freebase or HCL is about 10mg?

Maybe Freebase is 10mg and HCL is 12mg?

[Leo Gura]

@Goodpeace That's what the word about means.

[Psychonaut]

I need some help with plugging. I have 5-meo-dmt freebase. I can dissolve the freebase nicely in vinegar essence and need about 0.1 ml for 10mg. Now the problem is that vinegar essence is 25% acid and it's very strong. On lower doses let's say 30mg I would fill up my 1ml syringe with 0.3 ml vinegar and dillute the rest with water. With 0.5ml it becomes uncomfortably painful and I think it really not good for me.

Now what should I do? Somehow neutralize the acid in the vinegar essence or evaporate the vinegar and then dillute with water? I have no idea.

[Leo Gura]

@Psychonaut Add more water to fill the whole syringe.

A mild sting is normal and fine. Suck it up, buttercup.

Edited November 19 by Leo Gura

[Psychonaut]

 

2 minutes ago, Leo Gura said:

@Psychonaut Add more water to fill the whole syringe.

A mild sting is normal and fine. Suck it up, buttercup.

I only have 1ml syringes. I would have to get 3 or 5ml then. It's not a mild sting Leo. My ass is still on fire the next day. It's sore and I am no whimp on spicy food.

[Leo Gura]

3 minutes ago, Psychonaut said:

I only have 1ml syringes. I would have to get 3 or 5ml then. It's not a mild sting Leo. My ass is still on fire the next day. It's sore and I am no whimp on spicy food.

You are using too strong a vinegar then. Buy normal kitchen vinegar. It is not 25%.

You don't need more than 1ml. The amount of vinger to dissolve 5-MeO is a few drops.

Edited November 19 by Leo Gura

[Nemra]

@Psychonaut, why aren't you using HCL instead of freebase?

It dissolves in water, although it stung a bit when I tried.

[Leo Gura]

Freebase plugs well. It is actually better than HCl, 10-20% more potent.

But it stings a bit more.

Edited November 19 by Leo Gura

[Nemra]

18 minutes ago, Leo Gura said:

Freebase plugs well.

What do you mean by that?

18 minutes ago, Leo Gura said:

It is actually better than HCl, 10-20% more potent.

I think that less potency is not a bad thing in this case.

We can always add more.

Edited November 19 by Nemra

[OBEler]

@Nemra use freebase, add 1-2 drops of vinegar and 1-2 drops of water. Ready to go.

[Nemra]

35 minutes ago, OBEler said:

@Nemra use freebase, add 1-2 drops of vinegar and 1-2 drops of water. Ready to go.

Perhaps I'll try the freebase next time.

However, I rather not overdose.

I wonder if there is a qualitative difference between freebase and HCL when dosages are adjusted to achieve the same level of potency.

Edited November 19 by Nemra

[Psychonaut]

42 minutes ago, Nemra said:

@Psychonaut, why aren't you using HCL instead of freebase?

It dissolves in water, although it stung a bit when I tried.

Because the shop on the clearnet I get it from only has freebase and I don't want to go to other sources just for HCL.

[Nemra]

@Psychonaut, ok.

[Leo Gura]

1 hour ago, Nemra said:

We can always add more.

You can always add less.

[Leo Gura]

If you have the option to buy freebase or HCl, buy freebase. It is 10-20% more potent per gram, and it vapes well, and it plugs well. So this covers every use case.

The only point of salts is if you are going to IV it.

If you buy the salt, you will be limited in your ability to vape it, which is not ideal. You want that option.

Edited November 19 by Leo Gura

[Leo Gura]

1 hour ago, Nemra said:

I wonder if there is a qualitative difference between freebase and HCL

None

[Nemra]

Yeah, having the option to vape is also preferable.

Ok, I'm convinced.

I wouldn't mind having more options even if it stings a bit more.

Plugging gets tiring for testing.

Edited November 19 by Nemra

[Nemra]

@Leo Gura, when you say "it plugs well", what do you mean?

I know that I will understand when I try it, but I'm curious.

[Leo Gura]

3 minutes ago, Nemra said:

@Leo Gura, when you say "it plugs well", what do you mean?

I know that I will understand when I try it, but I'm curious.

I mean it dissolves easily, fits in a syringe, and absorbs easily.

Some chems don't plug at all. Like DMT or Salvia.

Edited November 19 by Leo Gura

[Nemra]

@Leo Gura, ok.

I thought you were comparing freebase with HCL of 5-MeO-DMT regarding plugging.