Help with Plugging 5meo - No results so far..

[Jasper23]

I've been working towards plugging 5meo freebase and not experiencing any significant trip so far and would love some suggestions on how to progress from here. Should I just keep upping the dose to 0.040-50? 

I've had several breakthroughs vaping 0.015-20mg.. but don't like the feel on my lungs. 

Trip notes for Plugging so far. 

First trip - 1 red micro scoop - effect nothing

Second trip - 1 red micro scoop - effect nothing

 

Third trip - 2 red micro scoop - 0.013-15mg on scales - Subtle effects - mostly a sense of somatic relaxation, but no visuals.. Meditated for 20 minutes.

Tried redosing a similar amount.. but nothing additional in terms of effects apart from more of a body load and deep relaxation with subtle visual distortion.

 

Fourth Trip - 3 red micro scoops - 0.025mg - 31.10.2026

Looks like 0.003-0.005 doesn’t get sucked up into syringe

And some crystals get caught in the tip of the syringe upon administration

So the actual amount reaching my system could be -0.010?

Deep somatic release after 10 minutes.. similar to sub breakthrough when vaping..  But not much more than that in terms of effects.

Re-dose 0.036 on scales - 4 red micro scoops - waited 30 minutes with almost no additional effects.

 

[Psychonaut]

First of all the microscoops are in mg (milligram). Please get your numbering system and units of measurement right, before playing with very potent psychedelics.

A typical red microscoop is about 5mg = 5 milligram = 0.005 gram = 0.005g

Please don't be an ignorant american prick with your stupid imperial shit numbering system. Thank you.

So start with 10-20mg. Dissolve it in water first. If it doesn't dissolve in water you need to add an acid. Rewatch Leo's video of safe drug use before continuing your inner research.

The dosing range for 5-MeO-DMT plugged is [20-80mg]

• 10mg-20mg starting point
• 20mg-50mg normal exploration
• 50mg-60mg entering danger zone

Edited October 31 by Psychonaut

[Sammy123]

@Psychonaut Calm the fck downn

@Jasper23 Did you dissolve your freebase in kitchen vinegar first?! I had my first trip plugging freebase and I dissolved it in kitchen cooking white vinegar from the supermarket. This mightt help you  - 

 

Edited October 31 by Sammy123

[Leo Gura]

Some people are immune to plugging, for unknown reasons.

Your doses are pretty low.

Try a substantially larger dose.

[Jasper23]

8 hours ago, Leo Gura said:

Some people are immune to plugging, for unknown reasons.

Your doses are pretty low.

Try a substantially larger dose.

I've plugged ketamine several times with excellent effects.. and I did notice some effects from the 5meo.. so it's probably a dosage issue rather than immunity. 

When you say substantially larger.. how much exactly? 2x? that would put me around 50mg - 60mg?  

If 25mg and 35mg did very little, then that seems the logical next step. 

I'll have a crack and report back.  

 

9 hours ago, Sammy123 said:

@Psychonaut Calm the fck downn

@Jasper23 Did you dissolve your freebase in kitchen vinegar first?! I had my first trip plugging freebase and I dissolved it in kitchen cooking white vinegar from the supermarket. This mightt help you  - 

 

Yes mate, I added a few drops of vinegar with about 0.3ml of water. Perhaps ill try with more vinegar next time and try crush it up more. Thanks for the vid  

[Leo Gura]

3 minutes ago, Jasper23 said:

When you say substantially larger.. how much exactly? 2x? that would put me around 50mg - 60mg?  

Keep doubling the dose until you get a proper trip.

Make sure you poo before plugging. Do not plug without pooing first. Poo will ruin it.

Edited November 1 by Leo Gura

[shree]

Plugging has never worked for me. I've tried some extremely high doses several times.

 

[Psychonaut]

58 minutes ago, shree said:

Plugging has never worked for me. I've tried some extremely high doses several times.

 

Hmm  that is really odd.  Have you tried plugging other chemicals? MDMA is readily absorbed through the lining in the ass. I can't imagine how one chemical like 5-MeO-DMT is not absorbed through the lining while others are. But maybe there is a gene or a reason that I am not aware off and if there is research on it I would be interested in seeing it.

[PsychedelicEagle]

16 hours ago, Leo Gura said:

Keep doubling the dose until you get a proper trip.

I think this is dangerous advice.

If you improperly administered 2x in a row a dose that would otherwise be effective, you'll end up in 4x stronger trip, substance-wise. And since psychedelic's effects are often non-linear, the subjective difference can be 10-100x+, who knows.

I would not double but instead increase 5-10mg each time. And make sure the total is not beyond what's generally considered safe.

Edited November 1 by PsychedelicEagle

[Psychonaut]

With 5-MeO-DMT go max +20mg per trip. I have explored the entire dosing range from 20-80mg over many years.

[Leo Gura]

22 hours ago, PsychedelicEagle said:

If you improperly administered 2x in a row a dose that would otherwise be effective, you'll end up in 4x stronger trip

I did not mean taking double doses back to back.

Don't re-dose mid trip.

Edited Monday at 03:39 PM by Leo Gura

[PsychedelicEagle]

On 11/2/2026 at 4:38 PM, Leo Gura said:

I did not mean taking double doses back to back.

Don't re-dose mid trip.

I didn't mean back to back.

I meant:

1. Week 1: 20mg — improper plugging technique (otherwise would have worked)
2. Week 2: 40mg — improper plugging technique
3. Week 3: 80mg — BOOM! 

[Psychonaut]

10 minutes ago, PsychedelicEagle said:

I didn't mean back to back.

I meant:

1. Week 1: 20mg — improper plugging technique (otherwise would have worked)
2. Week 2: 40mg — improper plugging technique
3. Week 3: 80mg — BOOM! 

 Good stuff hehe

[Leo Gura]

2 hours ago, PsychedelicEagle said:

I didn't mean back to back.

I meant:

1. Week 1: 20mg — improper plugging technique (otherwise would have worked)
2. Week 2: 40mg — improper plugging technique
3. Week 3: 80mg — BOOM! 

Yeah, well, if you do things so improperly then nothing can save you.

[Psychonaut]

Hmmm

[Jasper23]

On 04/11/2026 at 8:34 AM, Leo Gura said:

Yeah, well, if you do things so improperly then nothing can save you.

 

On 04/11/2026 at 5:46 AM, PsychedelicEagle said:

I didn't mean back to back.

I meant:

1. Week 1: 20mg — improper plugging technique (otherwise would have worked)
2. Week 2: 40mg — improper plugging technique
3. Week 3: 80mg — BOOM! 

Today I tried 50mg and felt almost nothing.. Waited 30 mins and then went to take a shit and it hit me while on the toilet as I released my bowles. Not a breakthrough, but somewhat close. I figured perhaps I just didn't clear my bowels enough.. So I tried 50mg again 30 mins later.. and again nothing with a slight kick when I took a shit again.. similar to a sub breakthrough vape.

It does seem to be able to absorb through that area, but only while passing stool.. I thought holy fuck, i'm gonna breakthrough while taking a shit lol.. not the most relaxed location, but perhaps in the end it doesn't matter.. Would this indicate that I'm still too low? or plugging improperly? 

I'm using vinegar with freebase, crushing the crystals, inserting the syringe about half way, slow plunge and then sitting still. Seems kinda strange to get almost zero effect with 50mg.

Just keep testing and upping the dose to 65mg and then 80mg? 

Thoughts and suggestions welcome
 

Edited 3 hours ago by Jasper23

[Jasper23]

On 04/11/2026 at 5:46 AM, PsychedelicEagle said:

I didn't mean back to back.

I meant:

1. Week 1: 20mg — improper plugging technique (otherwise would have worked)
2. Week 2: 40mg — improper plugging technique
3. Week 3: 80mg — BOOM! 

Yeah, I'm fearful of that as well.. it's creating a fair amount of anxiety every time I plug waiting for onset

[Psychonaut]

10 minutes ago, Jasper23 said:

 

Today I tried 50mg and felt almost nothing.. Waited 30 mins and then went to take a shit and it hit me while on the toilet as I released my bowles. Not a breakthrough, but somewhat close. I figured perhaps I just didn't clear my bowels enough.. So I tried 50mg again 30 mins later.. and again nothing with a slight kick when I took a shit again.. similar to a sub breakthrough vape.

Would this indicate that I'm still too low? or plugging improperly? 

I'm using vinegar with freebase, crushing the crystals, inserting the syringe about half way, slow plunge and then sitting still. Seems kinda strange to get almost zero effect with 50mg.

Just keep testing and upping the dose to 65mg and then 80mg? 

Thoughts and suggestions welcome
 

What I have done in the past is I would open up the syringe and pull the plunger out. Then cover the front on the syringe, where the nozzle should be. Drizzle the crystals in from the back of the syringe. Then put the plunger back in. Turn the syringe upside down, so that gravity pulls the crystals into the back of the syringe. Then carefully push the plunger in to the end. Next step is to pull a bit of vinegar into the syringe so that the crystals dissolve. Adding heat via warm hot water helps also. You can put the syringe into a plastic bag and dip it into a warm water-bath to aid dissolving the crystals... When the vinegar has dissolved the free-base fill the rest of the syringe up with luke-warm water.

I hope this helps and you can follow my long list of tips/recommendations. You can always ask again hehe. 

You can jump from 60 to 80mg. But please be careful. Lie down and make sure that when you loose consciousness everything is fine.

Edited 3 hours ago by Psychonaut

[Jasper23]

1 hour ago, Psychonaut said:

What I have done in the past is I would open up the syringe and pull the plunger out. Then cover the front on the syringe, where the nozzle should be. Drizzle the crystals in from the back of the syringe. Then put the plunger back in. Turn the syringe upside down, so that gravity pulls the crystals into the back of the syringe. Then carefully push the plunger in to the end. Next step is to pull a bit of vinegar into the syringe so that the crystals dissolve. Adding heat via warm hot water helps also. You can put the syringe into a plastic bag and dip it into a warm water-bath to aid dissolving the crystals... When the vinegar has dissolved the free-base fill the rest of the syringe up with luke-warm water.

I hope this helps and you can follow my long list of tips/recommendations. You can always ask again hehe. 

You can jump from 60 to 80mg. But please be careful. Lie down and make sure that when you loose consciousness everything is fine.

Thanks for the suggestion it makes sense. 

Should I try 50mg again with the melting technique or go for 60 since 50 did nothing last time?