Destroy your DNA for Profit. The Future 🌈

[integral]

https://www.facebook.com/reel/1313789310204703

Quote

Lower your cholesterol permanently by editing your DNA. One infusion, one letter of DNA, rewritten forever. That's today published in the New England Journal of Medicine. And as a cerebrovascular neurosurgeon that fights stroke, of course this is exciting news. But it comes with a twist that will make you think twice.

The drug is called Verve 102. It's a base editor. It changes your DNA. IV infusion delivers a CRISPR enzyme directly to your liver. And it flips a single letter of the DNA inside the PCSK9 gene. And the gene shuts off forever.

Your LDL crashes and it stays down. The trial was with 35 participants and it was at six different doses. And the ones at the highest dose, they had a 62% reduction in their LDL cholesterol. And this wasn't a transient thing either. It's 18 months and counting. Zero serious side effects.

And the internet is already calling this the end of heart disease. And the reason they picked the PCSK9 gene is not by accident. In 2006, a Dallas researcher, Jonathan Cohen, he discovered that patients that had naturally broken genes, they had a 28% lower LDL cholesterol over their lifetime. And to go along with that, their risk of coronary disease was 88% lower.

We saw that these patients basically had lifelong protection from cardiovascular disease from a single broken gene. And VIRV it essentially makes you one of these people But the truth is a 62 reduction in LDL cholesterol That something that you can get today with a statin and Zetia Two generic pills a few pennies a day decades of outcome data. So why in the world would you permanently rewrite your DNA for something that you can already hit at the pharmacy today? The honest answer is that not everybody can take a pill every day. Roughly half of patients quit statins within the first 12 months, and some genuinely cannot tolerate them. For those people, a one and done infusion, that's a totally different

conversation. That's a real argument for this drug, and I think it's a fair one. But keep this in mind, even when patients in the PCSK9 trials had their LDLs dropped down to the 30s, they still had double-digit risk of coronary disease over two years. Driving LDL down to the floor, particularly later in life, is not the whole story to coronary disease protection. So who might this drug actually be for? I think to start, a relatively small group of patients that have familial hypercholesterolemia that are at super high risk, or those that have a true

statin intolerance. And then of course, I think there's going to be a premium market of people seeking this out as a premium technology. Really fascinating and really exciting medicine. This is in vivo gene editing stuff inside your body while you're alive. But I think for most of us, two generic pills can probably do the job too. Would you get this irreversible gene editing done to lower your cholesterol? Let me know in the comments and follow along for more from the cutting edge of medicine right here from my treadmill.

Transcribed by Dictationer. Upgrade to Unlimited to remove this message.

Cholesterol being bad for you is a myth, cholesterol production clogging your arteries is a myth and modifying your DNA so your body doesn't produce cholesterol is so corrupt.

Can you imagine the immense damage they're about to do to our DNA justified by fake science?

Then they're going to make a culture around it as preventative DNA vaccines... 

A whole new set of crimes are now available, you can sprinkle a little bit of something into someone's drink to modify their DNA.

Edited yesterday at 03:54 PM by integral

[PsychedelicEagle]

https://www.rwapob.com/

Edited 23 hours ago by PsychedelicEagle

[Hojo]

This is the price we pay for trying to stop dying. It will get 1000 times weirder.

[Natasha Tori Maru]

Yep, this is what the techno-transhumanist silicon valley types are striving for.

Literally the movie 'Gattaca' manifest.

The ethics around this discussion are wild - and people don't even want to discuss it. It is just... drive to improve/expand at all costs. Dreamland future and fantastical thinking with zero foresight.

The road to hell is paved with the best intentions.

[PsychedelicEagle]

The fact that LDL (or, better said, Apo-B-containing lipoproteins) are causally related to atherosclerosis doesn't mean you need to inject yourself with a gene-altering drug. Diet alone is able to reduce it.

If you have familial hypercholesterolemia, however, as the OP wrote, it seems like a promising alternative compared to the other options. For sure better than having a stroke in your 30s.

Edited 10 hours ago by PsychedelicEagle

[integral]

6 hours ago, PsychedelicEagle said:

If you have familial hypercholesterolemia, however, as the OP wrote, it seems like a promising alternative compared to the other options. For sure better than having a stroke in your 30s.

They always use the one niche edge case where its very useful to then smuggle it into widespread use to the masses

The system is designed so that it will always spread medication's across a wide range of things loosely, it's not designed for application rigourously to one case situations.

A wise person would not release this drug into a system that operates that way, knowing it's going to be misused. Just because guns are useful for very specific situations doesn't mean it's a good idea to sell them at Walmart, because Walmart is a mass distributor

Edited 4 hours ago by integral

[PsychedelicEagle]

Yes, but you still need to sell them somewhere. Imagine having such condition and not having access to the medication that could drastically simplify your life and prevent diseases. 

[integral]

2 hours ago, PsychedelicEagle said:

Yes, but you still need to sell them somewhere. Imagine having such condition and not having access to the medication that could drastically simplify your life and prevent diseases. 

Yes, that's the ethical problem and the question is will this cause more harm overall than good.

And it's gonna cause more harm, most likely.