Which psychedelic has the biggest impact to cure depression

[OBEler]

@Hojo it seems you experienced some kind of "sleep paralysis". You just went deeper because during this state you lost time.

During and shortly after a sleep paralysis you have the opportunity to get out of body experiences. 

Overall a very unusual experience you described.

 

[Hojo]

@OBElerThe qualia of the experience was like this

 

[Psychonaut]

MDMA

[Psychonaut]

I recently discovered MXPCP. It has anti depressent effects for me. It won't be as draining as MDMA. MDMA is long. Depending on dose MXPCP is around 2-5hr.

[LambdaDelta]

22 hours ago, Psychonaut said:

I recently discovered MXPCP. It has anti depressent effects for me. It won't be as draining as MDMA. MDMA is long. Depending on dose MXPCP is around 2-5hr.

Interesting, I've heard similar things about it, at least that it's pretty light, social, and mood-lifting. Wasn't so great for me, it's confusing but in a lukewarm kind of way, not the total divorce from reality and journey to Wonderland characteristic of stronger stuff. It's also the most impure RC I've seen so far, Chinese lab standards leave a lot to be desired. Either the molecule itself has some weird properties, or they need to make a cleaner batch.

Have you tried DMXE? It's not as widely available these days, but is the closest structurally to MXE, the disso golden standard. PCP backbone instead of PCE makes a much more significant difference than methyl vs. methoxy. DMXE is noticeably warm, gentle, and synergetic, matched perhaps only by MXiPr.

Is MDMA really that long? Never lasts more than 4 hours for me. Maybe it's just genetic quirks, I also barely register the comedowns that people paint as horrible no matter how much I take, guess daily headaches have created an immunity over time. 

[Psychonaut]

@LambdaDelta I only recently have gotten into Dissociatives and it was quite a longshot for me. I didn't believe they would actually hold any potential for spiritual work. I was pleasantly surprised though.

For me though almost any substance, besides weed and alcohol are for spiritual work. 

In the shop I am ordering from there aren't so many substances available.

• 2-FDCK HCl
• 3-HO-PCP HCl
• 3-HO-PCE HCl
• 3-MeO-PCE HCl
• O-PCE HCl
• 3-Me-PCP HCl
• 3-Me-PCPy HCl
• 3-Me-PCE HCl
• 2-FXiPr HCl
• MXPCP HCl

Out of these 3-MeO-PCE sounds promising and I am considering ordering it. 2-FDCK I have already and it is cool too.

I fed this list to Google Gemini and it actually highlighted some surprising picks:

The "Warm Teacher": 3-HO-PCP

Why it fits: This is likely the closest upgrade to what you enjoy in MXPCP. Unlike the manic energy of standard PCP, 3-HO-PCP is widely reported to have a unique "warmth" (likely due to its affinity for opioid receptors).

The Experience: It is often described as tranquil, profoundly introspective, and "magical." It creates a safe-feeling headspace where you can examine trauma or complex concepts without the cold, clinical detachment of other dissociatives.

The "Deep Void": O-PCE

Why it fits: If 5-MeO-DMT is the "rocket ship" of tryptamines, O-PCE is often considered the "rocket ship" of dissociatives.

The Experience: It is famous for its "Hole" capabilities. It can completely disconnect you from your body and physical reality, placing you in a vast, abstract "void."

The Vibe: Unlike 3-HO-PCP, O-PCE is often described as cold, clinical, and digital. It is excellent for exploring the structure of consciousness or deep meditation, but it lacks the emotional "fuzzy blanket" feeling of MXPCP.

Edited 2 hours ago by Psychonaut