Being a sentient being (or a living organism in general) entails self-interest. There is no way to escape self-interest in a genuine way, even from an enlightened perspective. However, the enlightened have dis-identified with the separate self and thus realize that the self encompasses everything in existence. So, from an enlightened perspective, helping others IS self interest. However, make no mistake that any attempt to be helpful is influenced by self-interest. But it is just as self-interested NOT to do it, so go ahead and help... but be mindful. Notice how your desire for selflessness is self interested.