I've found 5-MeO-DMT to work just like it is purported to, and wanted to share a bit of my experience in case it's helpful to others. It's still fairly new to me, and I plan on continuing to work with it in the future. I have a fair amount of experience with all kinds of psychedelics, and in my opinion 5-MeO-DMT is a holy grail for it's ability to deliver the experience of kensho/god/monad/void/whateverthefuckyoucallit.
I'm not a very dedicated meditator, but I've been doing it for a long time, off and on. My recent experiences with 5-MeO-DMT have definitely motivated me to get back in the saddle (or on the zafu as it were).
I've been working with the HCL, which is best for insufflation rather than vaporizing. I've tried vaporizing the freebase, but that rubbed me the wrong way, so I abandoned that route of administration for myself, and now am sticking to snorting it.
My own dosing regime went: 1mg, 8mg, 12mg, 20mg. I'll probably push the dose a bit higher yet, but I'm not in any rush. For now, I'm content to let the last experience sink in, or permeate my life a bit more.