CosmicExplorer

Dennis Cyplenkov's hands "Doctors in Scotland were amazed when a 66-year-old woman underwent what is normally a very painful operation on her hand for severe arthritis and required little to no pain medication afterward. Similarly, two years ago, she was diagnosed with severe osteoarthritis in her hip with significant joint degeneration, yet she complained of no discomfort before, during, or after her hip replacement surgery" "She also scored remarkably low on anxiety and depression tests." "Thinking the woman’s exceptional insensitivity to pain might be rooted in her genes, researchers in the United Kingdom sequenced and analyzed her genome and found a previously unidentified mutation, they reported Wednesday in the British Journal of Anaesthesia. That mutation, in a region they named FAAH-OUT, seems to turn down the activity of a neighboring gene called FAAH, which is known to be involved in pain sensation, mood, and memory." https://www.scientificamerican.com/article/the-case-of-a-woman-who-feels-almost-no-pain-leads-scientists-to-a-new-gene-mutation/

Reminds me of his reasoning

@LSD-RumiBiggest hormonal protector from anxiety, depression and ptsd is probably high cortisol response to stress. Low cortisol response to stress is strongly associated with suicidal ideation and mental illness in general. Testosterone does increase cortisol response to stress

@LSD-Rumi No, but I want to. Dxm is the only dissociative I have an easy access to, worst side effect I get from it is strong nausea, I'm very prone to nausea in general. Do you get nausea from PCP/PCE?

@LSD-Rumi You mean the afterglow after dissociatives? I have that after DXM but there also seems to be tolerance building up to that afterglow effect, but I'm not sure. Do you think it would work if you would be using PCE/PCP every, let's say 3 days? Or is it more like mushrooms/LSD or MDMA where it only works if you take 2 weeks or longer breaks? If an afterglow lasts only 1 day, than it has to be done frequently to help depression

They do both, decrease brain activity and make the remaining activity more interconnected. Psychedelics has not been found to increase brain activity anywhere, if they do anything to a brain area, they only decrease activity. Meditation also decrease activity Which psychedelics? To my knowledge, no study has ever shown increase in brain activity on psychedelics, only decrease. This is the paradox - your brain is going to sleep but you have the most crazy, rich, meaningful experience of your life. Biggest argument against physicalism imo