CosmicExplorer

@Arthogaan "And just like Frank Yang says, that shift, of true centerless reality perceiving itself really feels like constant 5meo. " No it doesn't feel the same as 5-MeO God-solipsism. I dissolved that self-center feeling that Daniel Ingram or Frank are talking about, years ago and it doesn't feel the same as 30mg of snorted 5-MeO. Ask Frank to take a big hit of 5-MeO and then looking him in the eyes ask if it was just the same as he was 45 minutes ago, no way it's the same, you wouldn't even be able to function. Yes Frank has done frog venom but it was years ago before his Bhuddist enlightenment

For those of you who say looks is not important I mean dude became super famous right after they photographed him in a fucking jail. Thousands of girls started sending him naked photos within hours of his mugshot going viral. He received 45 modeling/movie contracts while still being in jail! It's insane what millimetres of bones can do.

Yes, status can do that. It's probably even more important than looks for attracting women. Questionable. I think even with an unattractive personality he would still be a desired man overall just because of his top 0.001% looks (he aged and doesn't look as good anymore). The problem with the black pill/incel community arguments is that they, to prove their points, show examples of not just good-looking men or even like really handsome guys, but the absolute top tier best-looking models on the earth. Yea I believe if you are so good-looking that people are willing to pay you to photograph you, you'll get laid easily even with an unattractive personality, however, that's so rare it's basically irrelevant. All decent looking guys still have to put some work to get laid The halo effect

Arguably the most important thing medicine, if powerful, should be able to solve or at least be able to give a big relief, is pain. Modern medicine is a joke in terms of giving people net pain relief. Opioids? Those do not give net pain relief after withdrawal or long-term use, also opium has been known since at least 3400 BC in Mesopotamia. NSAIDs are technically not painkillers*. The only thing with severe pain modern medicine can do is to smoothen out the pain/suffering curve with opioids, but again that is nothing new. Example from a rat study of how quickly tolerance develops to a painkilling effect of opioids: After about 18 days, a high dose of tramadol is not distinguishable from the placebo, complete tolerance has been developed. *NSAIDs are anti-hyperalgesic and anti-inflammatory drugs. Just like caffeine, Drotaverine, or many many other drugs that are not painkillers, can indirectly reduce pain in a specific scenario (hyperalgesia in case of NSAIDs). That doesn't make them painkillers. If you take an NSAID and then your wife of 20 years leaves you or hit your hand with a hammer, it hurts just the same. Opioids are painkillers and work directly by blocking pain signals between the brain and the body. The argument sometimes used is "Look how much longer people live now" but actually a lot of that is infant mortality which was much higher back then. Even 1000 years ago if you reached the age of like 6, your expected lifespan, and certainly healthspan, was not that much different than today. It was not uncommon for people to get to the age of 70, even 1000 years ago. https://news.sky.com/story/rare-genetic-mutation-allows-british-woman-75-to-feel-no-pain-12888007 In some sense, it's not surprising that natural selection cared so much about defending certain level of pain in the body and made all these negative feedback loops, as low pain phenotype is just too careless for it to survive well. There is one thing in long development now which can be a revolution in painkillers. FAAH enzyme, if eliminated, can potentially make a drastic change to the phenotype. There is even some evidence showing it can reduce and reverse tolerance to opioids. All the FAAH inhibitors tested to this day has been either too weak inhibitors and/or cause bad side effects, in 2016 someone even died in a clinical trial which unfortunately probably will delay research by years. The discovery such strong inhibitor would be incredible, chronic pain cured, anxiety and depression destroyed

Dennis Cyplenkov's hands "Doctors in Scotland were amazed when a 66-year-old woman underwent what is normally a very painful operation on her hand for severe arthritis and required little to no pain medication afterward. Similarly, two years ago, she was diagnosed with severe osteoarthritis in her hip with significant joint degeneration, yet she complained of no discomfort before, during, or after her hip replacement surgery" "She also scored remarkably low on anxiety and depression tests." "Thinking the woman’s exceptional insensitivity to pain might be rooted in her genes, researchers in the United Kingdom sequenced and analyzed her genome and found a previously unidentified mutation, they reported Wednesday in the British Journal of Anaesthesia. That mutation, in a region they named FAAH-OUT, seems to turn down the activity of a neighboring gene called FAAH, which is known to be involved in pain sensation, mood, and memory." https://www.scientificamerican.com/article/the-case-of-a-woman-who-feels-almost-no-pain-leads-scientists-to-a-new-gene-mutation/

Reminds me of his reasoning

@LSD-RumiBiggest hormonal protector from anxiety, depression and ptsd is probably high cortisol response to stress. Low cortisol response to stress is strongly associated with suicidal ideation and mental illness in general. Testosterone does increase cortisol response to stress

@LSD-Rumi No, but I want to. Dxm is the only dissociative I have an easy access to, worst side effect I get from it is strong nausea, I'm very prone to nausea in general. Do you get nausea from PCP/PCE?

@LSD-Rumi You mean the afterglow after dissociatives? I have that after DXM but there also seems to be tolerance building up to that afterglow effect, but I'm not sure. Do you think it would work if you would be using PCE/PCP every, let's say 3 days? Or is it more like mushrooms/LSD or MDMA where it only works if you take 2 weeks or longer breaks? If an afterglow lasts only 1 day, than it has to be done frequently to help depression

They do both, decrease brain activity and make the remaining activity more interconnected. Psychedelics has not been found to increase brain activity anywhere, if they do anything to a brain area, they only decrease activity. Meditation also decrease activity Which psychedelics? To my knowledge, no study has ever shown increase in brain activity on psychedelics, only decrease. This is the paradox - your brain is going to sleep but you have the most crazy, rich, meaningful experience of your life. Biggest argument against physicalism imo