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SQAAD

5-MeO-DIPT is Neurotoxic

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I didn't understand much from reading this to be honest. Maybe someone more scientific can interpret this data better than me and leave me a comment what does it actually mean. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047954/

Quote

 5-MeO-DIPT increased 5-HT and decreased 5-HIAA tissue content which seems to result from SERT inhibition. On the other hand, a decrease in DA, DOPAC, and HVA tissue contents suggests possible adaptive changes in DA turnover or damage of DA terminals by 5-MeO-DIPT. DNA single and double-strand breaks persisted up to 60 days after the treatment, indicating marked neurotoxicity of 5-MeO-DIPT. The induction of head-twitch response and potentiation of forepaw treading induced by 8-OH-DPAT indicate that hallucinogenic activity seems to be mediated through the stimulation of 5-HT2A and 5-HT1A receptors by 5-MeO-DIPT.

 

Edited by SQAAD

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