Brocolli sprouts promote detoxification of heavy metals

[Twega]

 

On 3/15/2021 at 7:18 PM, The0Self said:

t can move heavy metals around (possibly damaging the system of a mercury toxic individual), since it has 1 thiol group, but it won't help you excrete them.

@The0Self

 

Studying Sulforaphane as an isolated molecule will lead to believe that. But what is remarkable about sulforaphane is the potent induction of NRF2 and the catalyzation and conjugation of glutathione.

On 3/15/2021 at 7:18 PM, The0Self said:

It can move heavy metals around (possibly damaging the system of a mercury toxic individual), since it has 1 thiol group, but it won't help you excrete them.

Any evidence for that? I have never heard of that in all the time I have been researching nutrition. I am highly skeptical of that claim especially because there is so much research into sulforaphane and its having a negative impact on heavy metals was not found, in fact, it seems the opposite is the truth from Jed Fahey who is a phytochemist and an expert in sulforaphane and health.

I am highly skeptical of people who use certain facts of biochemistry to extrapolate that to form an opinion on a complex system, like detoxification.

For example (as a thought experiment), it could be that people who have very high levels of mercury will not benefit from sulforaphane, but people who have low to medium levels of mercury do. Or maybe they benefit before exposure but not during, or after one month of exposure but not one day. In reality, this is how nutrition actually works. Saying a compound harms you in X condition because it contains an X structure is very limited and unholisitic. Especially knowing that NRF2 influences every system in your body.

[The0Self]

@Twega It's not exactly chem 101. The more holistic the foundation, the harder it is to explain things in full, but suffice to say, if it was found to have no negative impact on heavy metals, it isn't a chelator. Proper chelators, like ALA, when used incorrectly, will cause brain damage. If sulforaphane didn't cause at least some bodily stress due to redistribution, then it certainly isn't going to cause increased excretion of heavy metals / chelation -- though it really is useless to even refer to some compound's affect on "heavy metals" rather than the specific ones it actually affects. ALA chelates Hg, As, Fe(III), and Se, the first 2 of which are "heavy metals" -- notice lead is absent. For lead you need DMSA and/or DMPS, but they don't chelate intracellularly. There's much more to it as well but I can't remember every bit of it atm. Every chelator and proposed chelator has a long rap sheet; it's not exactly a mystery anymore what these compounds do.

And the thiol double hook issue is entry level understanding before touching the idea of chelation with a 30 foot pole. It's pretty easy to piece together; just takes a while, to actually see how this ends up affecting people in the real world. Any effective single thiol group compound vastly increases the likelihood of a mercury toxic individual being rendered bedridden.

4 hours ago, Twega said:

Studying Sulforaphane as an isolated molecule will lead to believe that. But what is remarkable about sulforaphane is the potent induction of NRF2 and the catalyzation and conjugation of glutathione

Even mentioning glutathione in the context of chelation is bound to make oneself slightly more likely a candidate for brain damage.

Edited March 22, 2021 by The0Self