Joe Rogan Experience #1234 - David Sinclair

[Soulbass]

 

[Soulbass]

David Sinclair (Biologist).
Anti-ageing / Longevity research.
____________________________

Intermittent fasting (one meal in the evening).
What you eat doesn't matter, it's when you eat that matter.
Skip breakfast & lunch, when you can.

You need a period during the day, when you're hungry,
and it put your body in a "defensive" mode.

Restrained diet + exercise = caloric restriction, makes animals lives much more longer.

Resveratrol = GOOD (found in plants, not in alcohol).
Resveratrol + caloric restriction = BEST.

Supplements :
- Resveratrol (half a gram a day).
- NMN
(both works together, taking one supplement without the other is non-sense).

When you're 50 old, you have half the level of NAD than where you were 20 old.
That's not good.
NAD level is boosted by NMN supplements.

Avoid sugars & carbs.
Orange (fruits) juices, have too much sugar in them.
Don't over-eat.
High blood glucose = shorter life-span.
Running, workout, cold bath right after sauna (extreme temperatures).
Switching between extreme temperatures, activates you're body defenses (anti-ageing).

Vitamin D + K2 (both works together).
Green leafy, vegetables, colorful vegetables...
An overload of iron damage cells.

When doing sports, try not to do "too much".
Get your body damaged enough, so it can repair itself and have the benefits,
but don't over-do it.

Anti-oxydants is a myth, in the field of anti-ageing. It doesn't work.

A "stress" that doesn't kill you, makes you stronger (live longer).
If you "stress" a plant, you get more Resveratrol from it (grapes).

High levels of amino-acids is bad, it accelerate ageing.
In the short run, amino-acids gives you performance benefits.
In the long run, it come back to bites you.

Your body have two choices :
1. Grow fast, reproduce fast, build muscles, cells divide... great in the short run.
2. Grow slowly = longer life-span.

The reason why "ageing" it not considered as a "disease",
is because it happens to everybody.
It's not natural, don't go with it.

The average farmer in Japan is 65 years old.
Same in China.
This drag the economy of the planet down.
Wasting money (trillion of dollars) on keeping older people alive,
for their last 10-20 years of their lives (dementia, frailty, etc).
This money could be used to solve : global warming, better education...
Anti-ageing is not a selfish act.

X-ray scanners is damaging your body (airports).
X-ray scanners changes your epigenome : the "reader" of the DNA.
Ageing/diseases is not caused by the lost of DNA, but the lost of the epigenome.
This is "noise" information.
When you are 80 years old, the CD/DVD that contains your DNA, is scratched.
What feels good when you're young, come back to bites you when you're old.
Sun exposure is good when you're young (Vitamin D),
but accumulation of scratches on the epigenome, bites you when you're old.
How to polish that CD/DVD, to get that information back again ?
This will happen in the next century.

Never recommend someone to "do something".
Just tell to people what you do, and let them makes judgements and try for themselves.

Being 50 years old is still young (sports, mental performances...)
Don't compromise on your health, when you get older.

Don't force kids to eat.

Researchers are afraid that their lives may have been vain,
if new researches proves that it wasn't true (same for Egyptologists).

[Space]

@Soulbass Interesting stuff, thanks!