Michael569

@Schizophonia haha no worries its a fair question. Not really no. At least not with psychiatric meds. To he honest i have so little experience with medicine from a perspective of a patient that maybe that's a major limitation of mine. Maybe i was lucky to have been born with good genetics. I do have quite bit of experience with anxieties, panic attacks and dissasociation tho, I've had quite a few episodes over my life which I've always managed to get on top of without pharmacology and knowing the risk factors like alcohol and sleep deprivation helps me avoid them now. But I'm not qualified to talk about what it actually feels like to be on meds i guess

There is something to be said for distributing across as many markets as possible, ofcourse within the limits of safety. You don't want to buy bunch of Venezuelan bonds at 80% marginal value just to see them shrink over next 10 years to 10%. At the same time, if you are, for example, German, you don't want to invest only in German or European bond & stocks because your salary and your pension is already tied to the European economy so you would want to explore APAC, US, UK opportunities. But these days, most of the investment funds have a fair distribution among US, UK, Europe and APAC. I've not seen India markets specifically so can't comment on that. don't we all Read the Intelligent Investor, that gave me very good start into understanding the investment world. Actually read it, don't just skim over it. Highlight chapters and then return to them over and over. Its a book to be studied./ Overall, there are no shortcuts. Longitudinal research shows that methodical slow investing over decades where you take advantage of compound interest is the safest and most reliable way for most people to make decent money. This means sending a little bit of money each month and having multiple of such funds to diversify your risk. There are also a variety of pot options where you put money away for a year into a fund or a product and in 12 months you get them back with a compound interest. Your bank might have some of these available. You have to be a bit lucky to catch a nice AER (annual % return). I caught 5.6% last year and invested which brought me some nice revenue few weeks ago. This year it sank to 3.5% so I reinvested that money into something else. You can subscribe to European bank's newsletter (if you live in EU) to stay up to date with the current interest rates and evolution in the EU economy. Hopping from one fund to another, selling and buying couple times a day is only an option if you have extremely deep knowledge of the markets and if you can do this full time. It is incredibly dangerous too. You are competing with traders and banks across the world and it is such a thin ice to walk on. But many have made money this way so it could work. You also have to account for your age, your situation in life , your current wealth and how much of that you can spend etc,. For example spending half your salary each month on speculative investment is potentially a disastrous thing to do where investing methodically 10% of it into 10 different funds with distributed locations and distributed risk leaving them like that for 5-20 years is potentially a brilliant idea. I don't know how old you are but you're potentially committing a financial suicide. Do you not have to pay your rent / bills / food / travel and other expenses? Or if not at the moment, will you not in the future perhaps when you live alone or with a partner? Keeping some cash in reserve is a good idea. A good way to calculate that is, if you lost your job tomorrow and couldn't find another one, could you last 9-12 months at the current expense rate? That's how much cash you should hold. ( amount needed per month) * 12. Maybe multiple the whole thing by 0.9 if you think you could tighten your belt a little bit. You are a candidate for reading the Intelligent Investor indeed You can't if you do speculative investing like that. Committing 80% of your income into investing is almost like trying to be healthy on 2 hours of sleep. It will devastate your mental health because stakes are way too high and if you loose it all, if the market crashes you're left broke. Its basically gambling with your own sanity and self preservation mechanism. That's why you worry. Consider leaning more into slow sustainable investing that doesn't force you to check all the time and react emotionally to each small fluctuation. Ideally you would be checking maybe once a week or even once a month.

I've worked with lots of people taking some form of SSRI/SNRI, MOAI even TCA antidepressants, often combined with antipsychotics, beta blockers, benzos or occasionally even stimulants. What I've gathered so far is literally every single person has a completely different experience. Some tolerate them well but it dulls them a bit and to some they completely overwhelm their system. I don't love psychiatric meds because they can be hard to work around and prevent contraindications with food and supplements, especially when combined. At the same time I'm glad they exist, they save lifes and keep many people "further from the abyss". hope you'll find the answers to the underlining issue eventually

Sorry to hear that. In such case you probably benefit from not using it. Still, doesn't mean others wouldn't. I assume they control for the usage of antidepressants in those studies but I wasn't able to find it specifically being mentioned. Lot of people choose not to take antidepressants due to their side effects or for other reasons. Nothing wrong with taking meds tho if that's what helps you.

^ great post! There is so much more that could be said about coffee. You'll know almost immediately if it is bad for you by experiencing symptoms of rapid heart rate or jitteriness. Its fine for most people and long term benefits are well documented. Whether you get addicted to it to a point that you can't switch on your work laptop nor get yourself to the gym without being caffeinated is a completely different story. Unfortunately some people don't tolerate it well. It usually comes down to genetic mutation on certain hepatic enzymes or there is something else going on. People may have all sorts of inborn snips on key metabolic enzymes making them unable to digest certain food ingredients or particular amino acids such as phenylketonuria or different snips of P450 enzyme family. But that doesn't mean all those foods are automatically bad for everyone else. Knowing the nuances is important before bulk-rejecting entire foods or even food categories , e.g "carbs are bad because I get bloated from bread" or " coffee is bad because it gives me diarrhoea". Prospective evidence shows coffee improves the progression of depression and reduces the odds of suicide in people with mild to moderate depression. Would you take it away from them saying "coffee is bad for you"? ... I'd rather not. Sure, it doesn't solve the underlining issue of their depression but as long as it helps...

did you have to dig up a 5 year old post just to add that?

forgot about this gem !

Are you still predominantly focused on the carnivore diet, @Leo Gura?

There are some high value companies which are heavily stage green, you could look up vacancies on those. Companies like Patagonia, Ocean Bottle, Giff Gaff, Guardian, Finisterre, Tony's Chocolonely etc. You could have a look at the list of B-Corp certified businesses around your country. These are more likely to be engaging in sustainable business practices paying more attention to the longevity of the entire supply chain, the wellfare of the end manufacturer, farmers, avoidance of child labour, recycling practices, chemical spillage etc. https://bcorporation.eu/find-a-b-corp/

Investment is a long-haul game, don't let that clownery scare you and pull out your investment. The evidence shows that most people who invest long term (regardless of economic circumstances) usually earn as a result of compound interest. I think the aggregate yield, based on some studies done in the past on people investing into index funds (DJI, S&P etc) on average, was about 15-21% when investing over 10 years but I'd have to look up the exact details to be sure, it might have been slightly less. Even if you look at the long term trend of most index funds, they grow, despite monthly fluctuations. Speculative withdrawals and investments will most likely cost you because you probably don't have the skills and the knowledge necessary to compete with traders and trading organisations (most of us don't). Reading Benjamin Graham is a good intro into stage Yellow investing, into understanding how the market works and why you can't beat it in the long term.

@Scholar one thing I'd say is definitely test it first before supplementing high dose. Best do the full panel which includes: total iron, ferritin, transferin, TIBC and UIBC. That way you'll get the most holistic picture of transport, storage and acute need. Done alongside full blood count ideally.

Sorry to hear this has been going on for you. I'm sure you've probably tried tons of things but maybe this could help a bit. This is an anonymous case study of someone I worked with. This lady was diagnosed with acute thyroiditis, probably of infectious origin. Not autoimmune, so slightly different to Hashimoto's. She had to go on a 2 months cycle of prenisone which wasn't great but it helped quench the inflammation although there were side effects. I recommended some blood tests to her doctor and after some examination, we found that her iron was critically low. Her vitamin D wasn't great either, and on top of that, she was recently made redundant and went through a lot of stress. Even after that prednisone, she would often feel tingling in her thyroid as if the inflammation was trying to come back. Some things we did was@: replenish her iron with 200mg of iron bisglycinate per day for 3 months, got her vitamin D in the upper 80s (ng/mL), Secondly, we made lots of adjustments to her diet. She increased her antioxidant intake from pomegranates, broccoli, purple cabbage etc. She's been regularly making lentil vegetable soups in an Instapot. She also introduced more fibre and probiotic foods in the diet. She also reduced her consumption of sodium-rich processed food, sugar, saturated fat (especially from high fat dairy) and sweetened drinks. Thirdly, we severely restricted her sodium (temporarily) intake because she lived in a country where salt might have been iodised and sodium in general can be inflammatory in excess. I encouraged her to seek out iodine free salt. In some countries this is not an issue but maybe worth checking. I think her Zinc was also low but we never measured it. She took a 30-day course of Zinc Citrate And finally, she also started to exercise more, especially cardio and aquatic exercise. She found a gym that has a sauna and says it has been helping her. Retrospectively I think her issue was significantly weakened immune system that has trouble mounting up a proper response. She was also quite sedentary so her lympatic system which houses tons of her B-Cells and T-Cells wasn't being moved. Her low iron was probably a major contributor and so was her stress. The antioxidant intake was to help mop up free radical storm around her body caused by the inflammation and help support cellular defences. - as of now, the last I checked with her, her thyroid results were almost normal, with TSH being slightly above 2 but no antibodies detected. Her CRP has calmed down too. She says she hasn't felt that thyroid tingling since August which correlates to the time she started exercising more so maybe that was the last piece of a puzzle. - not sure if its gone or if it'll come back, it might. But those things seemed to have helped. Also, one more thing we added that I think helped was this. It is quite expensive and not sure if you can get it in your country but my client swore this made a difference. https://www.designsforhealth.uk/shop/inf120-pl-inflammatone-120-capsule-554#attr=1740,1011,1267,1332,1704,1918,61 I think we went up to 8 capsules a day in the beginning and than downwards from there. Thats significantly over the recommended intake so I'm not making any recommendation, just saying what we did. We obtained her doctor's approval first. One thing she herself added was drinking 1 litre of tea with ground ginger (about half the size of a thumb), 1 tablespoon of raw honey she bought from a countryside beekeeper in her country and 1/2 lemon. Sometimes she added Cayenne pepper to it, it must have tested gross, but all those things have anti-inflammatory properties, so I was happy to encourage it. So I'd say on the top of everything you're already doing, you could investigate your blood work, ask for a full iron panel test , maybe add vitamin D into the list and see if anything comes up. Look into that salt iodisation too and ensure you're not using one that contains it. Ramping up your antioxidants is likely to be of benefit. And I'm sure you're already physically active but if not, that's of an importance too. If anything else in that report resonates, give it a shot too. With regards to Iodine supplementation, caution is advised as it can exacerbate the inflammation if you supplement during a flareup, but best ask professional guidance on this as it is a very tricky topic. Look up best dietary sources of it if you're concerned. I believe you are vegan, correct? Still, there are options available such as seaweeds. hope that helps.

Landing page - depends on whether you need a personalised link (e.g. Ryanscourse.com) or you're okay with random link (e.g. btt.2689bgeidb.com) The first one will cost you and you'll need to pay either for a website (Wix, Squarespace,) or even use one of the mass mailing services like MailChimp or Mailerlite where you can customise a simple landing page. I'd suggest if you want to come across as a professional (depends on your market tho) having a proper website with a proper email such as info@yourcompanyname.com rather than ryan1998@gmail.com In terms of course, there are options like Udemy which you'll probably have to pay some money for publishing. It's often one off or monthly. The next step is advertising your course but I assume you have social media covered already. So it's really about how far you want to take it. How professional, If you wanna start building a brand or just sell something quick on social... either is an option.

Regular exercise will be important but you've gotta start paying attention to your diet as well otherwise the weight won't move. Just head to the nearest gym, speak to one of the trainers, book a few sessions so they can create a training routine for you then continue on your own. Sign up for at least 6 months. With regards to diet, if you're unsure where to begin, either consider hiring a professional (nutritionists/dietitian) or use AI to help you educate yourself or even create some sort of a meal plan. With time, patience and some commitment, you'll start seeing first results within a month.

@Fountainbleu can you elaborate on what you mean pls?

@Scholar could you share an update on the topic? Have you eventually found anything that helped?

? @Ingit my sympathies. I have a few people in the family either with ongoing or showing first signs. It is heart-breaking. It is important you don't blame yourself or feel fully responsible to become the primary caretaker for her. While she may need your support, it is important your life doesn't begin to revolve around your mother's condition as you'll grow to loath her for it. There are some good materials, videos and books on Dementia. Some really good videos shared above. If you are interested, you can educate yourself briefly on the condition, on what is happening and what are some potential elements that make it worse. To a certain degree you may have control over the progression however there is not yet an evidence of reversal being documented which saddens me greatly. But ultimately this condition is heavily affected by genes, upbringing and life long environment so consider what sort of support systems are available to your family. Wishing you all the best

Definitely don't need to spend all of that to match your requirements. Chat GPT is your friend to understand the specs in detail. Do you also want to game or is it purely work + graphic work? You need to aim for a decent integrated graphic card although you don't need the latest one. Most laptops come with a preinstalled one unless you're savy enough to add one yourself. Intel Core i7 processor unit is probably a good choice although Im not fully familiar with the individual sub-models but usually the built laptops will be calibrated well enough. You want a decently large SSD, I'd say at least 256Gb Or get something with a good split of SSD / HDD. As long as you use the processing of your SSD for the graphic operations and use HDD mostly for file storage you'll be fine. In terms of RAM, 32Gb is becoming a standard with higher tier laptops. I wouldn't go below 16 gig as you may run into memory distribution problems and lag. For brands unless you wanna go fancy like MSI or Razer or Alien, I'd probably stick to something like Assus, Dell or even HP. Have a look at each of their websites, filter by the cost and requirements and see what's there. Good luck! Watch a few vids, talk to AI but dont get stuck for months, most pre made laptops these days with decent specs are reliable.

Maybe the problem lies here. Why do you think the solution needs to come quick? Much of what is desirable to the labour market is hard to come by quickly. Desirable skills take years to acquire. Have you thought about bigger picture perspective? Are you lacking sufficient training or education? Could you be living in the wrong city / country? Do you need to finish College, complete a course to retrain etc? Is it possible that you have you trained your mind to only accept quick results? (e.g. listening to too much hustle culture content)

Hays would never contact you like this. They are one of the most reputable hiring agencies in the world. This is a scam. Recruitment Scam Alert | Hays Any WhatsApp job offer that offers quick buck without interview, proper documentation, third party screening etc is 99% likely to be a scam.

Ok i think it's time for a forum break once again 😅

Alright, well i appreciate the tag.. it was good to refresh a few things in endocrinology i forgot about so i appreciate that 🤜🏻🤛🏻 You can do that more often 😉 I'll leave it here, need to wash that french baguette with some British lard cream

fair point, words for words. Point stands. Why is temporary inhibition of 5AR (although I think its more like temporary reduction, inhibition indicates 100% loss of function) bad? You tagged me i this for a reason , right? even tho you knew I'd come after you with the hammer beating you for all your mechanistic speculative arguments Yes I agree, excessive soy (such as 1.2 litres of highly concentrated stuff) is a problem. Granted ! Soy in moderation is not a problem - can I get a concession on that? Eating a bunch of soy is NOT the same as being full of oestrogen, my god! Phytoestrogens aren't the same thing as biological oestrogens. That's an alpha and omega difference. Read into it. You're a scientist, you enjoy this shit so read a few clinical overviews of the phytoestrogen evidence. Let the research tell you the story rather than plugging up gaps in your knowledge with pseudoscience. Take it seriously and you'll see that all roads point the same direction. Being full of oestrogen which, I presume, means, your body is producing very high amounts, would either be some kind of genetic disease or a pituitary tumour or maybe even some sort of ovarian dysfunction or testicular tumour. The body doesn't just start pumping out hormones because you ate a tofu. Oh I am sure he has, that and PUFA has to be his favourite topics, that's where they can get lost in the pseudoscientific jungle. well, at least you're not a carnivore so that's good

delete? Soy doesn't delete anything. You can't just "delete" an enzyme that's coded by your DNA. If what you mean is temporarily reduce function of 5-Alpha Reductase then that's probably a good thing isn't it? But I don't care about mechanisms. Show me the outcome data. Show me the evidence (in humans) that soy products in moderation cause any endocrine problems? For each of those I have a study with 1000s of people showing protective effects. Ray Pete thinking all over again

All individual case studies , children who were probably fed too much soy by parents. That's obviously a bad idea. I'm more interested in protective effects of soy against chronic disease, some of those meta analyses I listed had over 5,000 - 10,000 participants. No to mention case studies are at the bottom of hierarchy of evidence for a reason. Still....very interesting to see that effect on kids in excess. Good learning lesson for sure dude hypogonadism is a medical diagnosis usually resulting from testicular trauma, testicular cancer or undescended testicles in boys. I think we are throwing around the terms a bit too freely. If what you mean is lower levels of testosterone then I'd want to see that in long term adult studies. good to know! Lots of men do have gnaecomastia who don't eat soy. I mean you see guys with manboobs all the time so clearly there is more going on. Simply being obese is likely a risk factor for it. ok so if that was the case, what would that mean? People who consume soy products become ...what? Look I know you have a great interest in endocrinology and I appreciate you have a good knowledge on it. I would even encourage you to go study something related to it. It is a fascinating subject and it was one of my favourite when I studies as well. But I think that's also become a bit of a barrier because you tend to be overly reductionstic seeing everything through the same lense. Endocrinology is tempting to use as an argument because it involves a lot of terms people don't understand that you can just throw around. But that won't fly here. If you are discussing the science you need to follow the hierarchy of evidence not randomly throw around endocrinology terms and pathways. You have to ask yourself - "if A causes B" then clearly most people who consume A regularly do get B? Do they? What's the evidence? Where is it? If I say a pathways XZY does this and then you say no, there is also pathway ABC that does the opposite. Who is right? How can we tell? That's why you have human outcome data.