Michael569

Unlikely to be permanent change even if it does short term

You are right, to a large degree.There is a lot of crap science out there, bad methodology, personal bias, financial incentives and data distortion. But there is a lot of good science out there too and a lot of researchers who care about more than just getting published. You don't go into medical research to become rich - at least I hope most don't. Maybe I am being naive but most folks I met in this industry are honest, are not making big buck and are fairly passionate. In general the outcome of any research is NEVER definitive. It only shows possibilities and associations and from those, we can learn. No study can ever tell you "definitely do this and this will happen" - but a well-designed trial can help us estimate roughly how things will evolve if we do XYZ. I mean how else are we going to know about potential health hazards? Self-experimentation? Sometimes that is tricky and can be dangerous. I would rather take on board whatever I can learn from those who came before me - even if their data isn't perfect, as long as it is all pointing similar direction, chances are pursuing that path is likely to be least risky (e.g. using fluoride containing toothpaste as an example) than pursuing an alternative where the direction of the effect is all over the place. With an example of fluoride in dentistry, these experiments are actually relatively easy to design because most likely, you are already taking people who are a bit lazy and don't care too much about their health (e.g. people with progressive periodontal disease where you are already assuming a large degree of neglect over a long time) so even if you give them Toothpaste A to try for 3 weeks and give toothpaste B to another group, it is unlikely they will go and turn their entire life around - people like magic pill solutions, they don't want to work hard for their health (I've seen a lot of that in my practice as well) . And people like being given an important task (e.g. being part of a study) so they will do what they are told if it could mean getting solution easily. I mean ofcourse! Nothing works for everyone. There are thousand things that could be causing Leo to feel the way he does and maybe for him hormonal replacement don't do shit - doesn't mean they are useless for everybody. Again, we are only doing our best with the information we have. Most doctors don't have the liberty to experiment if they don't want to lose their licenses. Alternative practitioners do which is both blessing (if it works) and a curse (if it goes wrong).

@Schizophonia no you're good. I liked your response but I never got around to reply properly and didn't want to half -arse it. I appreciate reasonable feedback but what I really hate are the types of responses i was commenting on (e.g. " all science is corrupted" "nothing can be trusted" )

these types of absolute statements always make me laugh. Not everyone out there is trying to get you and scam you of your money. Have some faith in the good of the humanity for fuck's sake. There are lot of scumbags and thieves out there but most folks are fairly honest and kind....

That might be the same elsewhere but think of the long term possibilities. A cashier is unlikley to be promoted and change her income over lifetime. Junior dev can be promoted to more senior roles and exponentially have their salary increased over time. I don't know the first thing about IT development but I'm sure with more seniority the amount of stuff Chat GPT can do as well as human diminishes. It is good at the basic tasks but it has no mastery in anything, it is just an information platform. Turn yourself into an expert in the field and you will attract better opportunities. There is, of course, always the possibility that this is not the right thing for you and that you should be pursuing a different area of expertise altogether. If you hate Spain, why not try living elsewhere? Germany, UK, Austria, US - all offer plenty of opportunities to young people with ambitions. Moving countries is the easiest it's ever been and with EU Passport the Europe at least is your playground. UK (post Brexit) & USA will be a bit more difficult but you could get invited and transferred over by a company (if you ar good enough). If you are young, flexible and (I assume) unmarried without kids, then this is the perfect time to do it. You can always come back to Spain in 5-10 years with a pack of new experience - worked well for me and many others who did the same.

It makes for a nice green poo, that's fur sure. If that's not worth the 80 bucks for a box of Sun Chlorella then I don't know what is

Ya I get that It comes down (at least for me) to having an internal piece of mind. The feeling of not constantly needing to be on the lookout for the next thing trying to kill you, is worth more than avoiding the remaining 2% of toxins. Not all synthetic products are bad tho: Toothpaste containing fluorides are most likely pretty darn important, just don't swallow that stuff on purpose. The evidence on benefits against cavities is pretty darn robust - sure there are other ways but water brushing might not be enough with the diet that humans have in 21st century. The risk of dental problems at the expense of few nanograms of fluoride per day that absorb through oral mucosa (which I am not even sure actually does) is not worth it. You will do more by avoiding alcohol-containing mouthwashes - that stuff has actually bene linked (albeit marginally) to oral cancer risk If you intend to date, find girls and get married then you can forget about that if you are not going to be using some form of washing liquid for your clothes and your body, or at least a decent natural soap. Women like guys who smell nice & are clean. To be frank not using any of that to me sounds a bit creepy and weird (I am generalising here, not speaking directly to anyone). No wonder a lot of these stage green people are always single - some can be really difficult to live with, don't become one of them, it seems to be a pretty miserable form of living. If the stuff for washing your dishes bothers you, wear rubber gloves during it. Just don't have disgusting and greasy cutlery - I've seen that in some people and it made me wanna vomit. The water just doesn't do it as well if you have oil on the plate. What you're left out are poorly washed dishes and cutlery I am yet to see an example where "100% natural living " (e.g removing all synthetic products) has actually led to something better. I've seen it lead to a lot of neglect, dirt, dust and kinda gross households. Adding a bit of stuff back can make a lot of difference. There is ofcourse the other side of the coin where people overuse this stuff and use 50 different products but we are talking about the other side of the spectrum here. You can use all this stuff and still be avoiding more than 90% of exposure which btw comes from water , food and air you breathe, the rest compared to those 3 is small. But again, ignore all of this if it doesn't click with your value system. This is a journey you need to walk alone. My health journey took around 6-7 years and during that time I went down the weirdest fucked up rabbit holes before finding the balance again. So do carry on but be mindful of the suffering some of this stuff causes and be honest with yourself when reflecting on these different practices,

The deeper you go down this rabbit hole, the more miserable you become. Seen it on myself, seen it in others, seen it around here. Just a word of advice from someone who's nearly gone mad with all the toxin avoidance, I tried to do couple years back...it was also the most unhappy I've ever been. Just accept that some exposure is inevitable and from that place take a rational standpoints and adopt few practices that help you find a healthy balance without becoming mad each time you have to come in contact with a synthetic product Example: buy a dish soap from a relatively conscious company then move along Example 2: if you washing machine is making you anxious, don't use it and wash dishes with hands using just a bamboo scrape and some essential oil soap - then move along. Example 3: get an eco egg for your washing machine, mix it with something that seems natural enough and then move along. Ignore if the advice doesn't resonate, maybe you need to experience the misery this stuff causes first hand No criticism there, just a friendly advice

The issue with real life experience around this topic in particular is that most of us around here are too young, so none of us would have actually felt the consequence of eating a high saturated fat diet such as getting a heart disease or stroke. This is, for me personally, the biggest issue I have when guys in their mid 20s tell me "I eat tons of red meat and I feel fine" - it is an irrelevant anecdote because the real downside effects might become apparent in their mid-50s by which time most carnivore eaters will be on a cocktail of medication preventing rupture of arterial plaque with a severe arterial calcification but you won't know anymore because all these conversation will be long forgotten. Consider asking this on a forum where you have a higher population of older men and the answers might differ. This forum where the most population is 22-28 is the wrong place to ask.

Yes!! Got it on the shelf already ready to go. I wish he wouldn't be so dismissive to epidemiology and nutrition tho but his CVD & exercise content is top notch. I'm a member of his private group, worth getting for any health nerds out there. He's a bit too heavy on the pharmacology side which I'm on the fence with

Chat GPT can find stuff but how do you know it can make the accurate conclusions? I think you are putting yourself in harm's way by outsourcing all your critical thinking to AI not to mention it is a bit disempowering.

that's not how you're supposed to validate your claims with research that's pure cherrypicking. The best quality research actually requires specific filters to find, what you're likely to find through Google is stuff most commonly used by influencers and marketers or the ones that have the most fancy title. Once you stop googling studies and actually dedicating time to reading the high-quality ones, most mechanistic evidence (e.g. Ray Pete type of content) dies in the process and gets superseded by human outcome data./ That sounds to me like a regirgutation of mechanistic pathway you read somewhere. All these mechanisms interact with thousands of other pathways which is impossible to capture in in-vitro study (once again I'll mentio the name of Ray Pete because I've seen you copy his content and I think that's where you are finding these - Ray Pete is not a good exmaple of objective researchers - he is extremely biased into mechanisms that sound cool but may not be the most accurate representation of the impact on the human health. In-vitro studies and lab animal studies are prone to the most biases and errors in conclusions which is why they sit so low at the hierarchy of evidence. Give me a practical implication of this for human health staying away of mechanisms (e.g.l that receptors and that neurotransmitter etc). How is more DHT better than less DHT all things being equal? My argument is that high DHT is a risk factor for prostate cancer that 1/8 men get and if they had lower DHT they would survive longer. What would you say is the strongest argument against that where high DHT is beneficial and the benefit is worth the risk of PC? those are two contradictory statements. Can you unwrap this for me pls? That's cool, I'm glad that is working for you. Maybe the effect on your depression could be achieved through other means too? Maybe one of those supplements is also targeting multiple other pathways. I would still be cautious with widely recommending to people online such protocol due to the above cancer risk. It's the carnivore argument all over again - eating more beef makes people's digestion better but it also increases their APoB. What is bigger risk - IBS or heart disease? How do you know that? Most people eating those foods do not end up with hypothyroidism. In fact the only evidence of this phenomenon has been observed in rats - This was very well discussed in Alex Leaf & Paul Saladino debate - both being subjct to their own biases ofcourse. But let's assume eating brassicas (most likely goitrogens) does increase the risk of hypothyroidism by say 10%. Considering that massively reduce the risk of cancer of the reproductive system & lungs, would that be a tradeoff worth making? I'd argue that it is. Also goitrogenic substances get deactivated by cooking so as long as you're not juicing ounces of kale you should theoretically be fine if you get those from cooked food. And finally, statistically speaking, people with goitrogen will test deficient on iodine tests so maybe goitre development has nothing to do with goitrogenic substance and is a pure sign of major deficiency. that is intereting, I've never thought about that. Migth be true. But then it increases the odds of atherosclerosis which isn't ideal. In the end all these things can be managed with medication so you are able to get treatment for anything that occurs, the question is what is worth the ultimate risk? If being stronger is worth the risk of early coronary obstruction then people should go for it. I guess getting benefits from DHT modulation for depression might be worth for you if you're happy to accept the other risk factors. It's always a balancing act. People need to be given all the information when making these choices rather than being exposed to marketing and cherrypicking which I have a personal grievance with. I'm just trying to present the dark side to you that you might not have considered That's all

@Nilsi right, gotcha. First of all, I appreciate the criticism, it is certainly pointing some blind spots that I need to work on. Yes, sure, full disclosure, everything I say here has a spin of my own bias - of course it does !!! You do the same and so does everyone around here. We all wear the filters of our own perspective and biases and those shape our perception of the world. You should critically examine everything you read around here automatically. I try to actually be unbiased where I can which is why you see my advice changing over time but sure, there is lot of it there still. With health advice this is tricky. With philosophy (or political theories such as Marxism) for example you might be able to follow all sorts of rabbit holes, try them and then come back and try something new. No harm done. With nutrition, going down wrong rabbit holes for couple years could mean irreversible damage to health and since we only got one of those i am perfectly happy to follow a consensus of the evidence because, well, it's the best we got. It's not perfect, there is lot of garbage there but you can train yourself to spot it. If you wanna put your health in hands of charlatans, by all means but if I have information based on 100s of thousands of people who went before me, and who got the things i would like to avoid, and I can see a certain mathematical probability of X happening if they do YZ, then why not? It would be silly not to. I'm totally willing to put my ego aside in this, there is zero agenda in the type of health advice I share with folks which is probably why people consistently disagree with me, and that's totally cool. I'm always open to debate about this stuff. This is not just about sharing A study. I spend hundreds of hours dissecting this information, studying the methodology, potential biases in those studies. I don't pull stuff out of my ass. To give you an example, I used to be a huuuge seed oil and dairy denier. If you look up my past comments here, they were all against those things in a bit of a dogmatic fashion. But you know what? With more due diligence and more digging I came to realisation that they are not all that bad and a lot of what I share with folks has changed...this happens all the time. This is not about finding clients, in fact i haven't actually acquired a client from around here for over 7 months so it's not like I'm making a buck saying these things. Sure, if someone likes this and need some help, I'm happy to do that but you will not see me agressively promoting business around here other than my signature - which you are free to do as well and so is everyone else. I just really dislike people being told off what we clearly know are health promoting foods because of some made up chemical reaction and then pushed to following what is (probably) a health jeopardising diet. If you wanna call that "having a head in the sand" that's up to you.

@Nilsi can you translate all this jibberish to something practical for me to respond to please? Which part of what I said you disagree with and why?

Do you have any evidence for any of this? I mean actual longitudinal evidence that shows vegans are more likely to be androgen deprived. We can make mechanistic speculations all day long but has any of that actually been demonstrated in humans? Are cultures with highest green tea consumption more likely to have low testo levels? Any RCTs you can share where people are given green tea and their levels drop? Permanently or transiently? If green tea is so bad why is it consistently associated with lower incidents of Alzheimer's, Parkinson's, prostate cancer, breast cancer and mental health disease? Even periodontal health is positively impacted by it. If anything, if something was shown to reduce DHT in adults that's a MAJOR benefit. You don't want high DHT post teenage years especially if you have history of prostate cancer in family So If drinking more green tea will ensure i can skip a prostate cancer that men part 65 in my family are getting and the mechanism is DHT reduction (even at the cost of my strength at the gym going 10% down) then I'll say fuck yeah gimme more of that stuff.

Godspeed Matt, hope you'll find the peace you're looking for ?‍♂️

@KobywithaY Two major changes i would do there as per the comment earlier 1. Add some carbohydrates back - all that fatigue and low-ness is likely caused by carb deprivation. Protein can be used for gluconeogenesis but it's dirty, slow and inefficient not to mention (probably) heavy on the elimination system. 2. Cut down on red meat, butter and animal fat SIGNIFICANTLY if you even want to make it to your 70s. Your cholesterol profile is not good and you need to remedy that. In case of butter i would consider going for 100% elimination until you get your LDL in 100s and lower. I would treat that as a main priority for you rather than worrying about testosterone which bit seems alright, i wouldn't worry about it too much. Eating more carbs will push it up if your natural levels are higher.

@universe what about it?

I don't think it is too late. AI can already do a lot but for professional-looking webs, the human touch takes it one step further. I would just be cautious about the "for extra income part". Learning web design is likely going to require a large chunk of time & money so you might consider going into this all-in as a full-time pro. Of course, it will take some time to build it and get clients (unless you would prefer to get employed by someone instead which is easier) but the intention should probably be for it to either be your main income eventually rather than doing it on the side of something even more mentally challenging Or do you have another, bigger, idea that you want to be your main with havign web design as a side?

Seems like you are already trying to see the finish line before you even took the first step. The thing you choose is likely to keep changing. Just start taking action and in time you will learn which skills you need to master and which you can outsource. By doing the thing that makes the most sense to you you will naturally gravitate towards the important activities while cutting out the ones that can go. To give you a personal example, I've recently made a decsion to outsource a large chunk of design work to a designer so that I can liberate more time for my core activities that I want to master. I generally suck at design and havign someone else do it for me who is better and more creative will generate better results anyway as long as I can afford them. Just take the first steps and with time, the question will be answered to you

Hey, thanks for sharing your story. Could you share more details about what your diet looks like? What do you eat for breakfast, lunch dinner? What do you eat and what sort of foods do you avoid? you shouldn't have a high cholesterol at 19, has that been investigated? Being exposed to high circulatory LDL in life drives up your risk of premature atherosclerosis - that's not something you want to have so early. (hope you are not subscribing to "cholesterol doesn't matter" theory shared by a lot of carnivore people) Have you been checked for familial hypercholesterolaemia? Could it be connected to high red meat consumption? What were your LDL and non-HDL cholesterol levels? Did the panel include ApoB? Has your blood sugar been checked? Thyroid? Testosterone? The feelings you describe can be triggered by a variety of things and without more information, it is hard to tell. It could be coming from traumatic experiences early in life, living in a toxic environment, from more biological issues (e.g. gut dysbiosis, nutritional deficiencies) , thyroid issues, hormonal issues. Lack of purpose and vision in life is a common one too. Do you get outside enough?

You should just get one of those soda streamers. Makes just sparkling water, costs next to nothing (other than machine & electricity) and you can sweetened it up yourself.

What did you serve with the eggs? How were they prepared? Does this always happen with eggs? Does it happen with other food? What did you drink alongside it?

Those are your results. There is a non-statistically significant association between mindfulness and physical activity. That's A result. You don't need to find a positive association to have a valid hypothesis and valid research. Post hoc hypothesis is a common practice due to publishing bias but science is not immune to this. It all depends on you. If you think conducting the original experiment would teach you more (despite result being non-statistically significant) then you should follow your original intuition, otherwise, you run the risk of opening yourself up to major biases even while doing the new paper. Also consider that statistically non-significant often indicates lack of evidence rather than the absence of an effect. Sometimes the statistical power is low so confidence intervals are barn door and you don't get what you wanted but then 5 years later the amount of research catches up and it becomes SS (or it doesn't, confidence intervals widen even further and then you will be able to say "yah there is definitely nothing there" Just out of curiosity, how did you assess the SS? Did you run a forest plot in Revman?

That's a fair concern. Not everybody values health on a deeper level, at least not to the degree you would see around here. People know a bit about sugar and heard about saturated fats and processed food and know eating fruit is good but that, in general, is it. Most don't take any extra effort to understand any of the nuances. They simply don't care . You can help her appreciate her health more but there is a limit to what you can achieve without it coming across as criticism - that depends on her level of development, some people are fairly resistant to feedback and get easily offended. One of the ways are cooking together, shopping together and showing her how tasty healthy food can be. The other way people learn is when they become sick. She's unlikely going to change if you push broccoli sprouts and green juices on her so small steps over a long time is more likely.