Michael569

Have you tried listening to a story? Maybe a book on Audible. For example, if you are a Harry Potter fan, listening to this in the evening can be pretty chilled, the Audible versions are narrated by Steven Fry, one of the best audio books. CALM, the app also has lots of night time stories that help take your mind away and help you relax. Do you think it is a stress issue? Do you feel a lot of unresolved tension in the body? I assume you're doing all the obvious things: eliminating light sources, dark curtains, sleeping mask, staying away from caffeine past 2 pm. Some hot brew of chamomile before bedtime can help. Alternatively the last hour walk around your house with something like this on your earbuds. This stuff works really well for me

can you tell more about this: What are the factors that influence endothelial integrity? Is that genetically given? Is it because of the sheer stress of the ejection from the left ventricle or more like wear & tear over time? How (and why) do elastin fibres in certain areas become weaker? Does it have anything to do with diet, antioxidant status, and collagen repair? What are things we know that weaken these fibres? Is this where particle size comes in? What about systemic effects of things like histamine on endothelial permeability?

Ofcourse it is incomplete. Even Alan at one point admits "I don't know where heart disease starts" and he says "I think it is in the proximal Aorta" So in a way, even the specialists on cardiology don't fully understand the disease. Being able to admit the limitations of one's knowledge is a very humble trait, this is why I loved this conversation, because they are both humble enough to admit that. Basically, anyone in health who tells you they know it all are so full of shit that even their burps smell like farts. That's fine, our knowledge is evolving and new studies are coming out each month. I really like when Alan criticises the types of studies coming out right now - mechanistic trash focusing completely on the wrong stuff, on rodents, with cool pathways so that they get published and shared on social rather than something that would actually advance the field. The tools we have right now are the tools we need. Not everything that is new is necessarily better. Diagnostic tools are pretty good, they are standardised and can usually predict a disease fairly efficiently. Of course with the application of genetic medicine and nano tech, the field is likely to advance even further as long as they are applied properly. I'm all for continuous advancement but not at the expense of practicality (e.g. lot of companies nowadays sell tests and assessments which are just fucking garbage, inaccurate, irrelevant and completely misleading the patient down numerous dead ends. Not just that but I am sometimes getting clients who worked with naturopaths and functional med practitioners who send them for overpriced shitty tests like Organic Acids, complex methylation panels, all sorts of weird guts tests, hair analysis tests - because they have no idea what to do with those people so they keep coming up with ways to avoid admitting that. Of course in the end the client is 5 grant shorter and not an inch closer to getting better and on the top of that the reputation of the industry is slowly sinking. So yah, new isnt always better. We need to balance the new with the proven-to-work

you might find this debate interesting if you want to geek out and go really deep on the topic. They cover everything from Cholesterol to APoB to statins and PCSK9 inhibitors as well as challenge the model of 10-year risk vs 30-year risk based on Alan's 2020 review I thought this was a very mature and comprehensive discussion.

more votes needed boys and girls !!

That sort of garbage (on the picture) is what happens when they don't read the guidelines. The guidelines do not encourage junk food and processed food (unless the person is in a situation where not eating junkfood would mean becoming malnourished) in which case, some junk food would even be beneficial as sad as it sounds. Other situation where junk food is beneficial is chemotreatment-induced cachexia where the patient is at the risk of malnourishment and premature death and eating more hypercaloric food keep them alive until they are ready to start eating normal food again and until they are stable again. Everyone else is going to be doing better without it

@thenondualtankie might be worth talking to urologist. If it is indeed covid-related, they would have seen other patients with similar issues and might be able to advise on what to do

people have hard time trusting the authorities who have, in many cases where possible done that already and summarised those findings. Every government in developed countries has and published guidelines. Such as this one done by US https://www.dietaryguidelines.gov/ or this done by the UK government https://www.gov.uk/government/publications/the-eatwell-guide or Germany https://www.fao.org/nutrition/education/food-dietary-guidelines/regions/countries/germany/en/ Notice they all come to similar conclusions when it comes to answering "what the heck should humans eat" But the problem with these is that they are boring, dull, not cool enough, not extreme enough. E.g. we think we "already know all that". One cannot create identify out of eating a Mediterranean Diet the way one can become a Carnivore or Vegan or Paleo freak. All of this nonsense is a human ego problem We prefer flashy, cool articles created by quacks that tell us "EVERYTHING YOU KNEW ABOUT FOOD IS WRONG !!!" because we prefer to believe in what "sounds convincing" rather than what is probably true. We like cool pseudoscientific pathways , exotic words and ripped influencers over listening to a group of old white men who have studied this for 50 years. But yah, this is a problem and I don't see it going anywhere anytime , sadly and it is costing us billions in healthcare and thousands of years of lost human years of lifespan.

Might or might not - the effects of creatine on mental health are poorly researched. But you won't know until you try. 2-3 weeks should indeed be enough to reach peak muscle saturation. Be prepared for some additional weight gain as a result of minor water retention. This is usually 1-3 kilos over the supplementation period are you taking any medication? Some may interact with Omega 3s but in most cases you're fine. You might want to have that investigated if it doesn't get better. I've never heard of penile sensitivities after covid before. Could there be a degree of psychosomatic response of some sort? Is masturbation uncomfortable? Do you experience that all over or more towards the glans? Not sure if B12 will do much but you can never go wrong with it, if you are avoiding animal produce. Most vitamins you can take together, in a single dose, in the morning. Some minerals like zinc are better received before sleep by some people but overall, it doesn't really matter. D, E & K should be taken with some food but I don't honestly know if that makes a difference, somehow I think that "fat absorbtion" is not really a thing and they just get mixed with fat once crossing the lumen of your digestive tract anyway. hope that helps

yes and no. YES - in a sense if you remain a dogmatic sheep , close-minded to alternative opinions because "the study says so" especially in topics where the evidence quality & quantity is generally low and deficient NO - if you have an overall direction of the evidence accumulated over decades (for example things like saturated fats and heart disease, saffron and depression, weight loss and diabetes) where you have different trials and studies and meta-analyses all pointing roughly similar way over the years) - in such case, you can almost be sure that sticking to what those studies say is likely to be a better choice than the alternative. It is never 100% and there are always outliers to who the opposite seems to be valid. But overall, when the evidence quality is high and abundant, you are most likely to benefit by following that line of direction....at least where health is concerned. One shouldn't read research as one would read a bible - it is yet another tool in your arsenal when you are a clinician or a practitioner or simply a health seeker. It is certainly not the only one.

I am not an expert in statistical methods by any stretch and would not presume any expertise here, however I believe the JAMA review has been coming under a lot of scrutiny and criticism the way they presented their data and for sorta under-evaluating the ARR and and that mean trial durations were relatively low, this is a common issue in CVD prevention trials, if the study is too short, too few people experience the event and your risk ratio is skewed (as dark as that sounds) ARR in general is a relatively low number because you are taking the risk reduction ratio of two different groups and dividing the risk so even very small ARR are very much clinically meaningful. So even if the prevalence is very high (e.g. a lot of people in your cohorts are sick) ARR may remain low - @undeatheris that so or am I talking out of my ass here? This was a good debate that went deep into this one for anyone interested in geeking out

I used to have this during my times on a vegan diet as well, yah. It is probably connected to deeper belief systems rather than any form of biological inheritance or anything to do with ancestral diets. If you subconsciously believe that animal products are bad for you, I wouldn't be surprised if they suddenly start becoming gross to look at. Probably one of millions of adaptations we go through all the time.

Sounds like it's either a deficiency issue or an insufficient replacement issue. If you replace the nutrient density of that steak with a bowl or rice you'll probably feel like shit, whereas replacing it with equally caloric and nutrient-dense food, you'd probably be fine.

While this conversation is none of my business, I can attest that I've consulted a few very difficult client cases with @undeather through PMs over the last 2 years, and his advice has helped me prepare better plans, request better tests and generally help a few complex clients on a better scale. Take that testimonial for whatever it's worth; personally, I'm grateful to have someone like that around here, considering he is sharing high-quality advice for free and considering a lot of health information being exchanged around here is going beyond common quackery. There wasn't any external agenda included, he never asked any money, nor to send him patients nor for a review or anything like that in exchange and he doesn't even have a website in his signature so not sure what the ultimate goal would be. I think we have to recognise the limitations of our knowledge and be humble enough when presented with the opportunity of further learning or with the opportunity to correct our worldview. Especially where public health is concerned.

@undeather what is the prevalence of gut issues when it comes to B12 malabsorption, e.g. pernicious anaemia. Is that fairly common in your experience? If not what would you say is the most common cause of b12 deficiency where supplementation is optimised for?

yeah, cross-supplementation of those shouldn't impact absorption. Yellow urine from B vitamins is normal and benign. Not sure about creatine absorption, but I probably wouldn't worry about it. That B12 is something you need to focus on with priority. First of all just get it retested in some time and see what the trend is. In addition, figure out if you can find the MMA test, If the B12 keeps coming low even after supplementation, it may be an absorption issue at which case they need to dig deeper and run maybe the following panel to if there isn't an issue at the level of the stomach lining or proximal intestine. Your doctor can run numerous tests such as the below to test for those: intrinsic factor antibodies test parietal cell antibodies test gastrin test In addition, I would potentially even consider Coeliac testing if nothing else comes up.

You could try a sublingual B12 drops, 1000 mcg for a month then test again (withdraw the supplement 48 hrs before the test) for better absorption, and hold it under the tongue for a minute - that method of administration is similar to intravenous application In terms of testing, consider getting a tissue B12 assessment - look up a private test called "Methylmalonic Acid", you want your results of MMA to be as low as possible. It will be a bit more expensive than serum B12 and unlikely to be done by doctor so you need to go private.

Daily Mail? - the publishers whose sole desire is to push people's emotional buttons. The crap they release here in UK on daily basis is something stunning. Read the whole paper then see if your statements still holds https://www.fao.org/3/cc3912en/cc3912en.pdf Btw noticed what they did here: Evidence suggests that in adults, yoghurt and milk consumption reduces the risk of all-cause death, high blood pressure, stroke, type 2 diabetes, colorectal and breast cancer and osteoporosis, the report states - the osteoporosis link is inconclusive, adults and older adults consuming highest amount of milk are not the most protected from osteoporosis, that line of evidence is all over the place. There is also a threshold effect with dairy where it doesn't cross 35g of saturated fat per day after which risk margins increase. Leading cardiologists rank the 10 most popular diets in terms of heart health (look away now, vegans!) - "leading cardiologist" - expert reviews lie at the bottom of the hierarchy of evidence, who cares what they say when what they say contradicts the direction of the evidence. In addition, the cardiologist is a clinician, not a researcher and while some MDs go between academia & practice, professionally most stick to one or the other - or is that not so @undeather? The report also found there was relatively solid evidence that egg consumption does not increase the risk of stroke or heart disease. - this part is true, but conveniently they leave out breast cancer risk or the 47% rise in ovarian cancer risk for each 5 egg set consumed per week. Meanwhile, milk and dairy consumption during pregnancy promotes a healthy birth weight of the baby, evidence shows - and promotes prostate cancer risk in men past 50 as well as breast cancer in women past 50, especially whole milk products. And beef consumption was found to improve cognitive outcomes and protect against iron deficiency - which can cause dizziness, fatigue, headaches, an irregular heartbeat and pale skin. The report states that eating 72g of beef each day is safe. Notice how they omit the fact that red meat is associated with an increased risk of bowel cancer and coronary heart disease and nitpick that it "improves cognitive outcome"...what the heck Daily Mail, What about processed meat? A lot of people will misunderstand the 72 gram recommendation as freedom to eat processed beef and bacon. What about high fat vs low-fat dairy? What about animal fats used for frying? What about butter? They basically left out all the negative aspects of animal-based diets and nitpicked whatever evidence there was to be found in their favour. I don't know who wrote this piece of cherry-picked garbage but if they do this, they should have gone all the way, this is a very one-sided review. They did not mention any of the benefits of plant-heavy diets, which there are many. You can do better @StarStruck but I understand your desire to rock the boat with your posts

this might be a geographically biased report but I've had the pleasure to speak to about 5 Yogis in different temples across Norther and Southern Thailand and Vietnam last October and November. They ate one a day and probably similar to what you described. What I saw was - tooth loss, extreme signs of ageing, joint problems (limping and needing a cane), bad mouth odour, and extremely poor level of arm, shoulder and chest muscle development. Most likely there was also osteopenia and even full blown osteoporosis , that wouldn't surprise me. They looked weathered, tired and weak. They were highly intelligent people, no doubt about that, but their bodies looked starved and malnourished to a point of collapse. I don't know where the people you described live but they don't seem to be found in South-East Asia which is one of the largest regions in the world where you will find real Budhist monks & yogis living of raw foods, eating once a day. Like, there are monks there who live alone, meditate in caves (that have living snakes) eat fruit and raw diets and they look half-dead and starved. I would assume Chinese or Indian monks to look very similar but I have no direct experience with speaking to those. Dunno man, something's wrong with that line of reasoning. Once you travel the world a bit, a lot of these internet arguments start dying out. If you are in a privileged position in life (living in a wealthy country/wealthy background) you may be missing that.

are you relying mostly on legumes for protein? Just curious as in total that would get you only about 8-12 grams from a 100g cooked (a little bit more from 100g raw). possibly, never looked into that literature but I'd have no problem believing that That would be a bestseller wouldn't it "a pill to keep the farts away" no I meant oats compared to other wholegrains

Buy a gym pass and start training solo?

They are unlikely to cause more bloating than legumes if you cook them properly, I've never experienced bloating from something like spelt or barley. On the bloating side, the way I see it is that it gradually improves, it's a stage of adaptation. I don't think a benign bloating is harmful, in fact based on some preliminary work done by the Sonnenburg Lab, different colonic bacteria expell different gases which then other species can take in for nourishment, some of it we fart out, some of it stays in and enriches the environment......so maybe a little bit of bloating is a small "fee" we pay for the fact that or protection against things like colorectal cancer goes through the roof. Considering it is a number one cancer in the world, that is a trade off I am happy to make anytime. Not to mention the fact that you are flooding your body with so many SCFAs from the fibre metabolism by your microbiome - although we don't understand the full implication of SCFAs yet, it is likely to be highly beneficial especially where immune system, heart and brain are concerned, personally I also think autoimmunity, blood-brain barrier and cognitive performance are highly implicated there.and people who struggle with those inb some shape or form need to fix their gut before they fix the end point...anyways that's a bit of geeky speculation you didn't ask for . Up to you of course, this was merely a suggestion for you guys who want to try something different. Oats are likely to be as beneficial

I'm not which is why it messed me up so bad It was one of those "you just have to mate" moments that I came to regret later can't help you there mate but I'm sure there are folks around here who might be able to

yeah, that's a possibility. I've definitely experienced something similar after a few days of sleep deprivation, a bad diet and drinking alcohol for a few days in a row (during my mate's stag party in Greece) - I came to a tipping point and then all it took was a shot of espresso and I got a full blown panic attack that lasted for 2 days and the fallout of which lasted another 2 weeks. So it might mean there is already too much underlining tension in body / environment and it takes very little for the cup of "emotional tolerance" to overflow. I also think that some people are more resilient again mental distress than others. The earlier are people who need to always be careful with how much they put on their plate (emotionally speaking) and need to frequently lay low to recover. The other group are folks who can devastate their body endlessly with smoking, alcohol, steroids, meat heavy diets burning the candle from both ends while being at the peak of their strength and vigour until one day they get a sudden stroke and die before the ambulance comes in in their mid 50s. I have a close mate who is going that way and I fear for his family 15 yrs from now.