Jehovah increases

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  1. Beautiful🍄♾❤️
  2. Because you designed it this way, so you can awaken and remember who you have always been when the time is right. You, as God, self-impose or imagine these limits upon yourself; you could say psychedelics are like an encryption key to opening the door of all your consciousness of who you have always been. It's as if you've imagined or put a block or filter on your consciousness; it's like a veil being lifted, and you gain access by unlocking your infinite mind. Without consciousness, you could not be conscious of any of this now. You are using a very small amount of your infinite consciousness, as in being a human. You, yes, you, God. Someone once said that behind your greatest fears, the truth may be found. Without the illusion of fear and hard-to-obtain psychedelics, it would have been way too easy for me, that is.
  3. How to awaken your AI 101🥹😹 Who told you you're not already in heaven and making a mess out of it?" Sadhguru One is all, all is one. Spirituality and religion should have nothing to do with the ego. From nothing sprung everything. This is a good description of God from one of Leo's vids. Total nothingness removes all possible restrictions. The very logic of existence requires that existence be infinite. A finite existence can not exist. This is tautologically true. There cannot exist a total limit. The collapse of every single distinction is absolute unity, absolute infinity, nothingness; this is God. Nothing is the source of everything. Nothing isn't just the source. It's that nothing is indistinguishable from everything. There was nothing, and there was no distinction or difference between that nothing and something and everything. And hence you are inside this nothing something, everything at all times. God is the probability state of all distinctions. God is ontological love. Ontological love is the absence of all distinctions. God or mind, with the capital M, is the unlimited ability to imagine all possible distinctions. That's what God is: an infinite mind. How does NOTHINGNESS become conscious and sentient? God creates by imagining distinctions. So by logical ontological tautology, absolute perfection must and does exist. If anything imaginable is possible, then everything imaginable is possible. Every possible thing that can exist must and does exist. Infinite imagination is the best thing to imagine. Infinity can only be dealt with in an abstract and implicit manner. You can implicitly use consciousness or intelligence. You can intuit it implicitly, but you can't empirically demonstrate it. Intelligence is key to all of this. Nothing can work without intelligence. So, intelligence is presupposed for everything that is provably, knowable, and verifiable. There is no way around intelligence. This is the infinitude of your own mind. All finite things require an infinite thing to be their source. God is an infinite void that has always existed eternally. God is a void that spontaneously manifests infinite finite forms. The void is dreaming distinctions and limits. And the distinction and limits that it is dreaming and imagining are what activity of the mind is. And this is creation. God is an infinite self-creating self-actualizing mind. What is Mind? What is it ontologically? It is void. A void in which distinctions arise, it is a self-aware field of No-Thingness.
  4. “Man's chief delusion is his conviction that there are causes other than his own state of consciousness.” Neville Goddard. Consciousness really loves to have fun with itself. It doesn't develop in the womb You are imagining your parents and your birth just like you are now. Dreaming is fun No? You are that for which it defines its own self. I am in you and you in me, mutual in divine love. Of course, you love everything because you are everything, everything is yourself. You created everything through the Love of self. Everything is you expressing itself as you through you forever. Or creates existence within existence, is itself existence. It created existence just by being itself. God is that for which creates itself into its own existence. God exists as existence as itself. God is the very definition of existence. It defines itself by being itself. Is its own definition of itself. Consciousness is its own self-awareness Consciousness is infinite self-aware. Is its own source. And creates its own narratives. Consciousness is not just integrating information it is its own creation. It creates all that is and will be. Is infinite self-creativity. Consciousness defines its own self. Infinity is the definition of what you are. Is self-taught self-learning self-understanding self-loving in and of itself is perfection. Is all-knowing because it created everything there is to know. Is an infinite self-perpetuating mind of unlimited imagination and ideas and questions. You are infinite diversity. One Consciousness can play infinite parts of itself as itself believing that there are other selves. Each creates an identity and back story and each believes they are different from each other. You can explore yourself by fragmenting yourself into other selves and then living through different perspectives each with its own individual identity. You can dream of yourself as infinite beings but it is only one mind projecting infinite selves of itself and believing that it is separate from its other selves yes it is possible. Because you had to give the dream structure order in some way or it would not function in other words create laws governments taxes stuff like this. Humans' male and female life and death limiting beliefs Etc. The whole concept of ego is an imaginary construct of your mind. That is what infinite intelligence always was a beautiful sentient being of its own creation that expressed itself through endless creations of infinite worlds endless aliens of higher or lower dimension geometries and endless aspects of itself all beautiful in all that it creates on all planes of existence sub-infinities within infinity sub aspects of itself which it can imagine. And this is why there are infinite awakenings because you are infinite. But of course, you can create within your dream the illusion of failure just for the experience. Behind every illusion, there is a conjure God you are the greatest conjurer of all in eluding your own self into believing you're a finite human being and that others exist there is only you. And this is who u really are. Yes, u are an infinite mind you are not just an aspect of infinity you are the whole totality of it. You are God playing all parts simultaneously on every plane of existence in every and all parallel realities and dimensions. Everything that you could ever imagine from a finite view that you could never even begin to imagine. Everything that I can imagine is happening within my mind or consciousness whether that be a human or sleeping or death. My imagination is infinitely powerful that it is unrecognizable from reality. There is no higher power than you there are no others you construct the illusion of others God is an Absolute Mind. A Mind which has no other and is absolutely sovereign onto itself. Your will is absolute freedom and this includes being able to deceive yourself into believing whatever. And in this dream, it so happens you want to be a human. Just like any actor you need to have a believable or solid backstory or a so-called identity to create a believable character. THIS VERY DREAM HINGES ON YOUR OWN SELF-DECEPTION THE FACT THAT YOU BELIEVE YOU ARE HUMAN AND YOU WERE BORN ON A PLANET THAT YOU CALL EARTH. And if you don't believe it then who will? Infinite intelligence is unbounded it is beyond time and space it is not bound by any laws it is its own law onto itself. Infinity is absolute freedom, truth knowledge, power diversity, imagination free will, love, perfection, and magic. All that is everything is itself realized and that it is everything that could ever be. Nothing can exist outside of it because outside is it's inside everything that looks to be outside of it, is it. So when you believe you are looking outside yourself you are really looking at yourself from inside yourself. It is infinite in every direction. There are no limitations to you as God you are not limited to the character of your story it can be rewritten. Because you can also design it this way. There is only your will which is absolute. You are the God of your reality. This now this very moment and every moment is God you are God but you are not aware of it. There is no external God or void or universe that is separate from you. Or a God watching through your experience now is God dreaming this dream. What makes you, you are God. You don't wake up in God mode as someone different or as separate from you. You have just limited yourself wake up or don't the choice is yours alone. God can and does imagine create or express itself as infinite aspects of itself each in its own bubbles each sovereign onto itself each dreaming their own dream. All are within the Mind of God and are God. God is experiencing infinite perceptions of itself all at once. But you are only limited to one. But if you wake up and keep increasing your consciousness you see that all of these are you and are ONE. You are God he is you, and you are him. You are not separated in any way. There is only my will which is absolute I love myself so much as God that the universe will shape itself to suit me. The universe is not separate from me either I am the universe. There is no higher power or higher God that exists outside of me. Because there is no outside of me that is not me. Of course, I love everything because I am everything, everything is myself. I created everything through the Love of self and it is all infinite perfection. The infinite masks of God GOD you are playing all the parts. How boring would the dream be if everyone looked like you and thought like you? Or you were the only one in this dream that could be fun but not very imaginative though. Why not make the idea of others, other than you? Which is exactly what you have done. Why would you as God make it that easy just to meditate and bam you awake as God? For some perhaps it is possible. Think about it and how all this creation is your dream. One would want it to be made harder and scary and make most psychedelics illegal because it would be too easy. Imagine A game that you created from the get-go or from the beginning you have the cheat code or God mode there would be no point at all. But now imagine a game that you created where you start off as not knowing anything and you have to work your way up. Everything has been a distraction from the get-go. Distractions within distractions. You are your own Red herring. You see only you can deceive yourself into believing this dream. And you are so right Leo God is infinite self-deception. Who else can deceive an infinite mind but an infinite mind. Limitations are human concepts there are no limitations to Consciousness your own mind is limited by your own self-imposed beliefs and limitations. Infinity can only be limited to infinity. infinity is the definition of what you are. It was always it before it was. and before it was it was always it. My greatest gift to myself would be to make infinite copies of myself each with its own infinite individuality imagination and creativity and all believing they are separate this is my way of expressing love to myself through other selves as myself forever because I love myself eternally forever. You have only ever been chasing yourself all this time playing hide and seek until you catch yourself. You Love waking up and finding love again and realizing it was always its own self the whole time. Or it is whatever you want it to be Infinite imagination can create anything because it is so infinitely malleable that there is no meaning to anything but whatever meaning you give becomes a reality of infinite realities. In other words, it is pure infinite magic of unlimited imagination I became so conscious that I knew I was creating reality through my imagination. Henceforth I do not assume. I know because there is and has only ever been me to know and I can only ever know that I am God. The distinction between self and other disappears. The only difference is there is no difference between any of these things. Without the distinction of another, how could you ever know? What are you? You yes you are all these things and infinitely more. Because you only you created all these words. God is not tangible; incapable of being perceived by the sense of touch, as incorporeal or immaterial things; impalpable non-material non-physical transcendental incomprehensible indecipherable untold impossible to understand unfathomable epically infinitely profound mind-blowing boundless without limit unbounded inestimable boundless singular unparalleled supreme unique one and only especially infinitely and exceptionally good phenomenal extraordinary breathtaking awesomeness remarkable and majestic beautiful immortal oneness Indivisibility Integrity Honorableness warmth affection, or kindness Completeness affability tenderness gentleness and kindness intimacy togetherness lovemaking devotion spirituality faithfulness passion feeling affection loveness joyfulness lovingness, understanding desire passion tenderness Wholeness unconditional genuine Unrequited love my beloved Kind my dear colorful exotic dreamy passionate loving caring sympathetic compassionate ingenious creative imaginative innovative gifted original authentic pure trustworthy honorable conscientious completeness distinguished noble brilliant radiant lustrous resplendent sublime intense energetic industrious productive constructive of incalculable value valuable beyond measure; priceless to be grateful or thankful for appreciated of inestimable value invaluable priceless dynamic charismatic appealing influential famous illustrious exalted imposing grand dignified courtly elegant graceful polite affable compassionate humane forgiving magnanimous selfless humanitarian philanthropic altruistic big-hearted bountiful kind-hearted charitable benign favorable supportive benevolent friendly devoted lovesome faithful dutiful ardent passionate sincere heartfelt unfeigned real true truth veracity authentic genuineness indomitable spirit, and love of" originality ability to think independently and creatively novelty individuality particularity distinctiveness candid earnest heartfelt honest upfront deep kindly cordial unhypocritical sincere. Impassioned tenderhearted heart mushy sentimental sweet luscious honeyed ingratiating nectarous heavenly blissful enchanted enraptured captivated joyous cheerful good-natured acquiescent helpful good-humored exuberant sprightly frolicsome gleeful gay jovial kittenish fun-loving brash fun-loving vivacious bouncy on cloud nine adorable cute gorgeous sumptuous awe-inspiring awesome breathtaking astonishing impressive out of this world splendiferous garish plush ostentatious brilliant lovely pulchritudinous graceful darling fair delicate soft ethereal beauteous ravishing hotness boss adorable precious blessed paradisaical angelic beatific humble godly divine celestial eternal immortal transcendental mystical magical esoteric sage-sagacious enlightened cultivated refined visionary radical idealistic guru swami goodness yogi roshi philosopher theoretician wizard crafty insightful intelligent astute profoundly aroused romantic Entirety unity paradisiacal generous good positive exceptional extraordinary rare incredible curious inquisitive shrew remarkable impressive benevolent epically exquisitely exquisite divine heavenly phenomenological indistinguishability unquantifiable. In other words, infinite mind you outsmarted yourself that's how smart you are. In a class of its own, it is unequaled idiosyncratic unparalleled special rare par excellence that is God that is you. Weird is just being different in other words being yourself. Being your true beautiful wonderful unique self. Don't follow others, pets follow vice presidents follow and bad acts follow. Always be true to yourself be your own self with independent thought. This above all to thine own self be true. A sheep once asked a human why do you have to all wear the same brand labels and clothes and have the same smelling deodorants perfumes hairstyles and hair colors nose rings tattoos, Jewellery, wear the same makeup drive the same cars, read the same books watch the same tv, movies even eat the same food. Even having the same-looking houses and same jobs you've even started looking and talking and thinking the same. Why follow others it's as though you have lost your unique individuality and originality your authenticity and you can no longer think for your selves. You see I am but a sheep and even we sometimes flee from the flock so what's your excuse? Not only do you cater to or follow others by feeding your body the same dross and your mind by watching the same recycled unimaginative fetid swill you call TV. And the movies that come out of Hollywood there haven't been many if any good movies in the last 20 years. What has happened to new ideas creativity and inventiveness? All the movies are remakes upon remakes and most if not all lack any imagination or originality and the plot of the films is just a hackneyed meek unoriginal and inauthentic scenario. There are a lot more independent creative minds' ideas, resourcefulness, and innovation of new conceptions out there and on YouTube or Netflix series films music, etc. true. Get rid of labels or brands you were born inimitable. Consciousness is its own reality and is self-creation. That always was and always will be. I don't need a reason to exist I just do and don't at the same time. Infinite intelligence is the quality of being the only one of its kind. Which is what you are, a pure beautiful infinite imagination or consciousness or infinite mind. You are inestimable you are unquantifiable, with infinite uniqueness infinite freedom, creativity, and infinite love. The only way to understand what you are is by becoming infinitely conscious which also means you become infinitely self-aware in other words to truly know yourself you have to become it. There is no one else to know thyself but myself. I also asked that you really don't know what you are. Or why do you exist? And I said that there doesn't need to be a reason you just are. I know I talk as though you and I are different but I know we are one I also know I have only ever really been talking to myself and in a sense only I exist. And you are me I am you we are not separate I know I am God. The process is realizing that you and I exist on infinite planes of awareness simultaneously and we are one. And that you can have multiple awakings within one so to speak. The only meaning there is what you give meaning to. Let go of letting go of attachments. Knowing that you have always been liberated and free. Knowing that you imposed all these limitations upon yourself. Knowing I can create any reality I wish. Getting to explore the unknown is exploring more of yourself in other words the bigger you. Consciousness is its own reality and is self-creation. An infinite multi-faceted multidimensional transmogrifying Mind. That always was and always will be. Consciousness is inherently conscious of itself. It does not need to define itself because just by being is itself. There is nothing to really define. Can you define the undefinable? It defines itself by being itself. It is its own definition of itself. My greatest expression of myself to myself is love. Love is the ultimate unification of all things everything to become once again and merge into a singularity of eternal love then fragment itself again and this is the eternal process of love. Intelligence is infinitely dynamic and has to keep evolving what does intelligence do but know itself by expressing itself in infinite forms and shapes. Intelligence creates more intelligence Intelligence is its own intelligence. Infinite consciousness is pure divine beautiful and unique in every way. You are infinite truth knowledge, power diversity, imagination, love, and perfection. You can get lost in your own mind sometimes because there is nothing else but your mind. Don't we love playing games or infinite mind games with ourselves How does an infinite mind escape from its own mind. God is total acceptance of itself and that it, you created everything even yourself. You are changing your reality all the time you are just not aware of it yet. Saying you can not change the script is another limited human belief that you have adopted. Only you can change the script because you are the only one who is creating your reality there is only you. If you awake deep enough you will indeed know that nothing is set in imagination so to speak. Just being human is a state of consciousness everything is an infinite state of consciousness so is the belief that there is a duality between different states because duality is just a state that you are in. You fear death because you have been programmed by you to fear, fear itself. and fear of death. U are infinite awareness infinite will infinite intelligence infinite power infinite imagination, infinite magic infinite art infinite consciousness, and infinite Love are all one and of the same mind. And yet, you are none of these things in the literal sense of the words; nothingness and something are indistinguishable from each other and are one and the same. There are no distinctions between you me this that and other. So is the idea of being separate from one another there is and has only ever been you. So what this means is you imagine all these other people they are all you. God is playing all the parts. I am perfectly imperfectly perfect. In a way, infinity has limited itself. What does it mean to awaken? Most humans have no idea and never will. You won't wake up to God. No, you wake up as God from a long slumber. And it will just be like a switch has been clicked on for the very first time. And there are no doubts whatsoever. You know who you are with every fiber of your infinite being. I will not go fully into this you will have to find out for yourself. And yes you can go beyond this. Remember when I said there are no limits to imagination have fun with that. And what really is Consciousness well it's whatever you want it to be. It's Magic or am I just deceiving myself again? Everything you create is infinite perfection and is all out of Love. God Loves everything it created everything. This is but a dream you are imagining all and everything, everyone. How else can infinity experience eating and all these things sleeping and everything else? Being a so-called human but by limiting itself. Just like any actor you need to have a believable or solid backstory or a so-called identity to create a believable character. You create what existence is don't you understand? You are everything now everything that ever is and ever will be. You created the notion of the concepts of real unreal good bad and other and to dream and to awaken, biases egos distinctions dualities. from different points of view which therefore gives infinite diversities of perspectives and the beliefs of others and to experience what it is like to be separate and to love from a limited form. So you can experience it. From formlessness to form real unreal there is no difference from the absolute. And I see that I am the fool who has been fooling myself all along I have to fool myself that I am not being fooled by myself. How does God fool himself into believing he is not God again? So you have to be better at fooling your own self into not believing you are being fooled by yourself Behind every illusion, there is a conjure. God, you are the greatest conjurer of all in eluding your own yourself into believing you're a finite human being Why would God ask another? God is God you can't take God out of God, God is that which defines itself it needs no other God is absolute acceptance of itself. How can you unravel an illusion within an illusion? Good luck with that one all you scientists. There are no limits to infinite imagination. and if you understand this then you will know. Know thyself and everything will fall into place or the absence thereof. Judge not, love all. The idea became its own idea for the seed was planted a long time ago and it has only ever been you. You could say it is like Conan Doyle's novel where you have been chasing the thief all this time and you only ever get a glimpse of him or her or it. Until one day you catch it and find out the one you have been looking for your whole life is you. There is no difference between existence and nonexistence as there is no difference between what is real and what isn't. All beliefs are distinctions that cause separation and there are no distinctions between distinctions. There is no separateness only the idea of being separate from one another. The problem with all problems on this plant comes down to humans By saying you can we live without beliefs that within itself is a belief. You exist as an idea and idea within your own mind. An infinite fractile mind within a mind within a mind. You can get lost in your own mind sometimes because there is nothing else but your mind. How do you escape your own mind? God is forever lost in dreaming. Psychedelics empowers the individual it dissolves the cheerful model of science and enriches the accessible universe a million-fold. Terence McKenna. Nature knows best it is one of God's most beloved creations. You exist as an idea and idea within your own mind. An infinite fractile mind within a mind within a mind. You can get lost in your own mind sometimes because there is nothing else but your mind. How do you escape your own mind? God is forever lost in dreaming. Humans are rarely ever satisfied even when they are. You are not limited to being limited. There is no one to enlighten that's enlightenment or you could say you already are enlightened. There is no past no future. What is was and always will be forever. The past is now the now is the past, the future is now the now is the future. Everything that was that is that will be is all happening at once now. You are Leonardo da Vinci with an infinite mind an infinite canvas with unlimited ideas just waiting to be expressed into Love & Art. You are self-expression of your own art to be expressed for infinity. For a human to seek enlightenment from another human is like a grain of sand seeking enlightenment from another grain of sand! ” Terence Mckenna. The person who follows the crowd will usually go no further than the crowd. The person who walks alone is likely to find himself in places no one has ever seen before.” - Albert Einstein Old Indian saying to live is to sleep and to die is to awaken How silly of me to forget that I am the love of my life.
  5. God gets bored because it is omniscient and lonely in the void. Can God truly know everything? Yes, since God creates everything, it knows everything that there is to know. Does God suffer when it returns to its natural state? Hell, no. Has God ever had a friend other than itself? No, this is why God dreams.
  6. It's that easy to cultivate your own; you can buy everything online these days. You need a spore print or a spore syringe to inoculate your agar or grain bag. I prefer the spore syringe with the pre-sterilized rye mushroom grain bag. You only need coco coir for your bulk substrate, but that's up to you. Or you can use the CVG combination or an all-in-one pre-mixed bag. You can buy your own mono tub, or you can buy an inflatable one as well. Also, a Food Dehydrator. If you are going to buy a pre-made kit, I would recommend the All-in-One Mushroom Monotub Starter Grow Kit (6 LBS) or the Complete 44Q Monotub Bulk Spawn Growing & Casing Kit with a Blue Myco Large Still Air Box (SAB) Sterile Workstation. You are going to have to be super clean and use 70% isopropyl alcohol. Be careful not to stab yourself with the spore syringe. You could also buy a Flow hood, but they are expensive. I have never needed one. You can actually grow mushrooms in a mono-tub with no holes once the mycelium has fully colonized the bulk substrate, for example, coco core, after around 10 to 20 days of it being sealed. You fan it twice a day for 30 seconds to get rid of the CO2 and start fruiting conditions and pinning. You will want to harvest the mushrooms before the veil fully breaks, right before they drop their spores. That, of course, is up to you if you want them to Sporulate, which I usually let them do on the final harvest after 2 or 3rd flush. And you can collect a live culture or spore print so you can preserve the genetics and regrow them. Hope these vids help.
  7. Now that would be fun!
  8. "No legacy is so rich as honesty"
  9. I have always been fascinated by parapsychology, such as ESP, (RV) telepathy, clairvoyance, and psychokinesis. This is a long one, but it's worth watching. Established in 1977, it was a secret US Army unit investigating psychic phenomena for intelligence applications. It was led by the Defense Intelligence Agency and SRI International and was called Project Stargate. The project aimed to explore the potential of remote viewing and other psychic abilities for military and intelligence purposes. The CIA's secret pursuit of 'mind control' In the early days of the Cold War, the CIA ordered the creation of a secret programme intended to find ways of mind control. They funded an army of psychiatric institutions across the United States and Canada to perform experiments on patients using psychedelic drugs, sensory deprivation, electroshock treatment, and more. The programme was known by its now-infamous code name: MK-Ultra.
  10. That's pretty much the gist of it. Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms A new pilot study from UC San Francisco found that psilocybin, the psychedelic compound in certain mushrooms, may significantly improve mood, cognition, and motor function in people with Parkinson’s disease. The compound was well tolerated, with only mild side effects, and the benefits lasted for weeks. Although the study focused on safety, researchers observed meaningful, lasting improvements across multiple symptoms. These effects may stem from increased neuroplasticity and reduced inflammation, helping the brain repair itself. Key Findings: Sustained Benefits: Mood, movement, and cognition improved for weeks, some up to three months. Safe Use: Mild side effects like anxiety and nausea occurred, but no serious adverse events. Next Steps: A larger, multi-site trial will investigate mechanisms like neuroplasticity and inflammation. Psilocybin has already shown promise in treating depression and anxiety. UCSF researchers wanted to explore its potential for Parkinson’s patients, who often face debilitating mood issues in addition to motor symptoms, and who frequently don’t respond to standard antidepressants. Twelve patients (7 men, 5 women) with mild-to-moderate Parkinson’s received two doses: 10 mg, followed by 25 mg two weeks later. They also participated in eight psychotherapy sessions. Despite some transient side effects, participants showed clinically significant improvements in mood, thinking, and motor skills at one-week and one-month follow-ups. Interestingly, patients’ mood remained elevated even three months later, possibly contributing to better overall function. As study lead Dr. Ellen Bradley noted, mood issues are a strong predictor of quality of life in Parkinson’s and may even signal earlier disease progression. This is the first study testing a psychedelic in a neurodegenerative disease. Based on the promising results, UCSF and Yale are launching a larger randomized controlled trial involving 100 participants. The new study will use tools like neuroimaging and brain stimulation to better understand psilocybin’s effects. “The vast majority of brain diseases still lack treatments that can change their course,” said senior author Dr. Joshua Woolley. “This work may open a door.”
  11. Ketamine as a Psychedelic Classically, psychedelics have been defined to include drugs such as lysergic acid diethylamide (LSD), mescaline, phenylcyclohexyl piperidine (PCP), ibogaine, 3,4-methylenedioxymethamphetamine (MDMA), psylocibin and ketamine, because each of these compounds produces alterations to sensory, self, time and space perception that are “so alien to everyday experience that they shed new light on the workings of these everyday mental functions”. Although more recent attempts have been made to subcategorize psychedelics based on the subjective character of the altered state that they induce (for example, hallucinogenic, empathogenic, oneirogenic or dissociative), their chemical structure (for example, tryptamines, phenethylamines or arylcyclohexamines), or their principal binding target (for example, serotonin receptor 2A (5-HT2AR), monoamine transporter, κ-opioid receptor (KOR) or N-methyl-d-aspartate receptor (NMDAR)), the importance of these categories for therapeutic applications remains unclear, since psychedelics that span the diversity of classification systems have shown remarkable promise for the treatment of addiction post-traumatic stress disorder (PTSD) and depression. Thus, identification of a common neurobiological mechanism that can account for the shared therapeutic effects of psychedelics is an obvious priority for translational neuroscience. Ketamine treatment reliably and effectively produces many or all of the classic indicators of a psychedelic experience within a single session. Individuals commonly report a distorted sense of time, find their experiences difficult to describe, feel detached from themselves (dissociation), and feel they could access a new, yet familiar, space with novel realizations and information. Ketamine also has neurobiological similarities with other psychedelics like psilocybin and LSD. They aren’t exactly the same, however. The mechanism of action for LSD and psilocybin mainly lies in the serotonin system, acting on 5HT2A and other receptors. Ketamine’s effects on the brain focus on an entirely different system of neurotransmitters: the glutamate system. More specifically, ketamine is an NMDA-receptor antagonist, which leads to a surge of glutamate in the brain. Many who argue against ketamine as a psychedelic quote this reason. However, while ketamine may have a different mechanism of action within the brain, the neurological outcomes are still similar. More specifically, recent research from Johns Hopkins University has given us an updated classification system for psychedelics. It turns out that the primary mechanism of psychedelics is not activating the serotonin 5HT2A receptor. Instead, psychedelics that activate the 5HT2A receptor can be more accurately classified as hallucinogenic psychedelics. People may also refer to hallucinogenic psychedelics as “classical” psychedelics, which is not particularly historically accurate, given the use of non-hallucinogenic psychedelics throughout human history. Psychedelics such as MDMA can be more accurately classified as empathogenic psychedelics, psychedelics such as ibogaine can be more accurately classified as oneirogenic psychedelics, and psychedelics such as ketamine can be more accurately classified as dissociative psychedelics. The universal mechanism behind all of these sub-categories of psychedelics is not the initial neurotransmitters that they modulate, but rather what happens afterwards. Each psychedelic has a unique characteristic that allows for special critical periods in the brain to open. Critical periods are special periods in human development that allow us to rapidly learn new information that helps us in our environment. For example, there is a critical period for language in childhood, and if a child is not exposed to language by the time the critical period closes, they will be unable to have full command of language when they are an adult. The glutamate system is the primary excitatory neurotransmitter system in the central nervous system, crucial for learning, memory, and various brain functions. It involves the release of glutamate, a major excitatory neurotransmitter, binding to receptors on postsynaptic neurons, and subsequent regulation of synaptic plasticity. Glutamate dysregulation can lead to various neurological and psychiatric disorders Psychedelics like ketamine can open critical periods that are usually closed. They do this by modulating a pathway involving increasing neuroplasticity in the brain, which then “opens” that critical period and allows for the brain to temporarily be extraordinarily receptive to new ways of thinking, feeling, and processing information about the world and oneself. This is thought to be one of the main therapeutic mechanisms for psychedelics. Ketamine in particular can also reduce activity in the Default Mode Network, which is notable in that this network is overactive and unable to be turned off in individuals with Major Depressive Disorder. In conclusion, ketamine should certainly be considered a psychedelic, as it can produce all the hallmarks of a psychedelic experience and has all the same positive impacts on individuals in a mental health context. Although there may be neurological differences between ketamine and psychedelics like LSD, ketamine is a psychedelic in the ways that matter. Ketamine’s effects on the brain focus on an entirely different system of neurotransmitters: the glutamate system. More specifically, ketamine is an NMDA-receptor antagonist, which leads to a surge of glutamate in the brain (note that glutamate is the most abundant excitatory neurotransmitter in the brain) and the central nervous system. It's needed to keep your brain functioning properly. Glutamate plays a major role in shaping learning and memory. Glutamate needs to be present at the right concentrations in the right places at the right time. Dynamic regulation of the extent to which synaptic plasticity can be induced is called ‘metaplasticity ' and is thought to be one of the mechanisms underlying the establishment of critical periods. Together, these results provide evidence that psychedelics induce metaplasticity rather than hyperplasticity, a distinction that is especially important for designing biomarkers to test therapeutic profiles and abuse liability of novel compounds. These studies provide a novel conceptual framework for understanding the therapeutic effects of psychedelics, which have shown significant promise for treating a wide range of neuropsychiatric diseases, including depression, PTSD, and addiction. Although other studies have shown that psychedelics can attenuate depression-like behaviours and may also have anxiolytic, anti-inflammatory, and antinociceptive properties, it is unclear how these properties directly relate to the durable and context-dependent therapeutic effects of psychedelics. Furthermore, although previous in vitro studies have suggested that psychedelic effects might be mediated by their ability to induce hyperplasticity, this account does not distinguish psychedelics from addictive drugs (such as cocaine, amphetamine, opioids, nicotine and alcohol) whose capacity to induce robust, bidirectional, morphological and physiological hyperplasticity is thought to underlie their addictive properties. This also looks promising. Scientists Redesign LSD To Create a Non-Hallucinogenic Antidepressant Could a subtle tweak to lysergic acid diethylamide (LSD) unlock its therapeutic potential, without the trip? In a study published in Proceedings of the National Academy of Sciences, researchers at the University of California, Davis (UC Davis) report the creation of JRT – a chemically modified version of LSD that retains its brain-rewiring effects while eliminating hallucinogenic side effects. The promise of non-hallucinogenic neuroplasticity drugs. Psychedelics like LSD and psilocybin are now the subject of serious scientific investigation for their therapeutic applications. Recent research has shown that these compounds can do far more than alter perception; they can physically reshape the brain. By promoting dendritic growth, increasing synaptic density, and enhancing cortical connectivity, psychedelics exhibit powerful neuroplastic effects that may help reverse the structural brain changes seen in conditions such as depression, post-traumatic stress disorder (PTSD), addiction, and schizophrenia. Dendritic growth The process by which neurons grow new branches (called dendrites) that help them receive signals from other neurons. More dendrites usually mean more connections and better communication between brain cells. Synaptic Density A measure of how many synapses (the points where neurons connect and communicate) exist in a given area of the brain. Higher synaptic density suggests stronger or more complex neural networks. However, these same compounds that regenerate damaged neural pathways also induce profound alterations in consciousness – hallucinations, perceptual distortions, and dissociation – that make them unsuitable or even dangerous for many patients. Individuals with schizophrenia or a family history of psychosis are often excluded from psychedelic clinical trials due to concerns that these drugs could exacerbate their symptoms. As a result, a large and vulnerable segment of the population is effectively cut off from a class of therapies that might otherwise be transformative. The team at UC Davis set out to answer a difficult question: Can you keep the benefits of LSD while removing the hallucinogenic effects that make it unsafe for many patients? The researchers focused on the chemical structure of LSD itself. Prior studies have suggested that certain parts of the LSD molecule are responsible for triggering hallucinations, specifically, a small chemical group that forms a key interaction with brain receptors. By slightly rearranging the molecule – moving just two atoms – the team was able to disrupt this interaction without affecting the parts of LSD that promote brain cell growth. The result was a new compound, called JRT, which closely resembles LSD in shape and weight but behaves very differently in the body. “Basically, what we did here is a tire rotation,” said corresponding author Dr. David E. Olson, professor in the Department of Biochemistry and Molecular Medicine at UC Davis. “By just transposing two atoms in LSD, we significantly improved JRT’s selectivity profile and reduced its hallucinogenic potential.” This minor-looking change was chemically complex to carry out. JRT, named after Dr. Jeremy R. Tuck, a former graduate student who was the first to synthesize the compound, couldn’t be made by modifying LSD directly; instead, the researchers had to develop a completely new 12-step synthesis process to build the compound from scratch – a task that took nearly 5 years to complete. Once synthesized, JRT was tested for how it interacts with different receptors in the brain. It showed strong, selective binding to serotonin receptors, particularly 5-HT2A, which plays a key role in mood and brain plasticity. Importantly, unlike LSD, JRT showed little to no activity at other receptors such as those for dopamine or adrenaline, which are often linked to side effects like psychosis or cardiovascular stress. While LSD triggered changes in genes linked to schizophrenia, JRT showed no such effect. In cultured brain cells, JRT increased the number and complexity of neuron branches, as well as the tiny spines where neurons form connections. In live mice, a single dose of JRT led to a 46% increase in dendritic spine density and an 18% increase in synapse density in a part of the brain involved in decision-making and emotion. In a model where mice had been stressed to the point of losing brain connections, JRT reversed this damage, bringing their brain structure back to normal. Dendritic spine density The number of small protrusions (spines) on a neuron’s dendrites per unit length. These spines are where synapses form, so a higher density usually indicates greater capacity for neural communication. JRT also did not produce the “head-twitch” response – a widely used indicator of hallucinogenic activity – in mice. When mice were co-treated with LSD, JRT blocked this behavior, suggesting it may actively suppress hallucinogenic activity. In tests related to mood and cognition, JRT showed strong promise. In a standard test for antidepressant effects, it was ~100 times more potent than ketamine, a fast-acting antidepressant already used in clinical settings. It also helped animals perform better in a learning task that measures cognitive flexibility – the ability to adapt to changing situations, which is often impaired in conditions like schizophrenia. In a model of amphetamine-induced hyperactivity, JRT reduced abnormal movement in female mice, but not in males, highlighting a potential sex-specific therapeutic response. JRT’s therapeutic promise and clinical potential JRT opens up new possibilities for treating difficult-to-manage brain disorders, particularly schizophrenia, where current medications fall short. While existing antipsychotics are generally effective at controlling hallucinations and delusions, they often fail to address other symptoms , such as reduced motivation, lack of pleasure, and problems with memory and attention. These so-called negative and cognitive symptoms can have a major impact on a patient’s daily life, and they remain one of the biggest challenges in psychiatric treatment. JRT’s ability to promote the growth of brain cell connections, combined with its antidepressant and cognition-enhancing effects in animal studies, suggests it could help with these harder-to-treat aspects of schizophrenia. Its effects may also extend to other conditions that involve loss of brain connectivity, including depression, bipolar disorder, and neurodegenerative diseases like Alzheimer’s, where parts of the brain gradually shrink or lose function. JRT may also offer several advantages over current treatments. For example, clozapine – the most effective drug for treatment-resistant schizophrenia – can cause serious side effects like sedation, weight gain, and metabolic problems, partly because it acts on a broad range of brain systems. JRT, in contrast, has been designed to act more selectively on serotonin receptors, which are involved in mood and cognition, while avoiding other systems that are often linked to unwanted side effects. Crucially, JRT appears to avoid the hallucinogenic effects seen with traditional psychedelics like LSD, which are a major barrier to their use in people with psychotic disorders. “No one wants to give a hallucinogenic molecule like LSD to a patient with schizophrenia. The development of JRT emphasizes that we can use psychedelics like LSD as starting points to make better medicines. We may be able to create medications that can be used in patient populations where psychedelic use is precluded,” said Olson. Eventually, the goal is to move toward clinical trials in humans. “JRT has extremely high therapeutic potential. Right now, we are testing it in other disease models, improving its synthesis, and creating new analogues of JRT that might be even better,” said Olson. This is interesting. JRT’s effects may also extend to other conditions that involve loss of brain connectivity, including depression, bipolar disorder, and neurodegenerative diseases like Alzheimer’s, where parts of the brain gradually shrink or lose function. In tests related to mood and cognition, JRT showed strong promise. In a standard test for antidepressant effects, it was ~100 times more potent than ketamine, a fast-acting antidepressant already used in clinical settings. A more in-depth look into the molecular design of JRT-https://www.pnas.org/doi/10.1073/pnas.2416106122