Only have experience with shrooms.
my first time with two grams i had but for sure didn't need a trip sitter. Nothing much came up, I did it mostly recreationally.
I wouldn't go higher than 3g without a tripsitter for the first time, and even that's pushing it. It depends on where you're at, level of emotional maturity awareness, etc.
They are amazing to take while meditating.
I've had profound insights
And i've tricked myself, doing self inquiry on them I thought I was getting somewhere but I was just saying who am i over and over again and giggling without even thinking what it meant.