Psygenlab

DOSAGE : 0.5 - 2 mg, orally DURATION : several hours QUALITATIVE COMMENTS : (with 0.5 mg, orally) "This stuff is an absolute poison. Within minutes I noticed what can only be called ear-ringing without any ear-ringing. Intense tinnitus with no sound, most uncomfortable. There were two waves of nausea and vomiting of yellow bilious stuff, with thick mucus for saliva. I can't think straight -- muddled. I can't get answers to questions because I simply cannot form the questions. Eyes closed to music gave no images, but the music sounded OK. Recovery was quite rapid, and I was together again in a few hours. Never again." (about 1 mg, smoking) "I managed to vaporize about a milligram of the material, and there was nothing profound. There was a slight feeling of calmness. As I felt sure that this material would be a quieting agent, I managed to vaporize and inhale what might have been up to another milligram. There were no psychedelic effects manifested, and I fell asleep easily 10 minutes later." (with 3 mgs, smoking) "Initially the compound exhibited a 5-MeO-DMT-like effect. There was a total loss of self-identity in a nearly instantaneous rush. I felt as if the top of my head was blown off at the inset of the drug experience. My observers told me that I had been unconscious for four hours. I remember reentering with the feeling 'God is Love.' After completely coming to, I felt very nauseous, and threw up in the bathroom several times. I felt drained and sick for the rest of the evening as well as mentally slow. By the next morning I was more alert and responsive, I have absolutely no memory of anything that transpired while I was on the compound." (with 3 mgs, smoking) "I inhaled the vaporized sample at 10 past noon. There was quite a rush. There were none of the shifting shapes, colors and forms of DMT. Nor was it acute with clarity or energy as with my many experiences with 5-MeO-DMT. The effect was intense but not terrifying, with a full body buzz and with humming resonance as I fell backwards into something where all memory was lost. I was told that at 18 past noon, I was unconscious. Something over an hour later, I started flailing, rolling about, quivering and shaking, and had very constricted pupils. In another hour I was able to talk lucidly, but quietly. In yet another hour, I was nauseous and tried for the bathroom, but didn't make it. The people who were watching me were alarmed. My actions were scary. And my skin looked funny for several days afterwards. There are longlasting properties of this. My first exposure was with perhaps a milligrams (smoked, also) and the effects were substantial, with rough edges and minor dysphoria." (with 4 mgs, smoking) "This was the free base. I remember the pipe, and the inhalation and, with the pouring of a small glass of scotch, I settled down in front of the TV to watch a re-run of Star Trek. That was it. I came to some time later in the front room of a professional ally of mine, who had by chance discovered me walking down the street near his house. I do not recall, nor have I been able to regain any memories of the time I was 'out there.' I apparently experienced no physical discomfort from the drug. In fact I distinctly remember feeling very comfortable when I awoke. Clearly this compound is some weird-ass shit."

Oberlender personally self-experimented with some of the psychoactive drugs synthesized in the Nichols lab.[3] In the mid-1990s, he tried the obscure psychedelic tryptamine 5-MeO-pyr-T, a synthetic analogue of 5-MeO-DMT, and accidentally took too high of a dose of it without a trip sitter present.[3] While under the influence of 5-MeO-pyr-T, Oberlender stripped naked, began wandering the Purdue University campus in a fugue state, and was apprehended by campus police.[3] His case did not end up going to court, but the incident did result in Oberlender having to leave Nichols's lab.[3] His experience with 5-MeO-pyr-T was subsequently published anonymously in Alexander Shulgin's 1997 book TiHKAL (Tryptamines I Have Known and Loved).[3][7] The chemist publicly shared further details of the incident during an interview with psychedelic journalist Hamilton Morris in 2021, describing it as a cautionary tale of the risks of self-experimentation with little-known psychoactive drugs and the importance of careful dose escalation and of having a trip sitter

inspiring infos from hamilton 5-MeO-DMT / 5-MeO-MALT / DPT are known by Actualized.org rarer psychedelics like 5-MeO-pyr-T has crazy affirmity and selectivity- Selectivity: selectivity makes one compound stronger for specific purpose, LSD has strong affirmity for 5-ht1a as 5meodmt, yet as equal selectivity to 5-ht1a which it makes it also too visual. 5-MeO-pyr-T series sound so cool. they could last potentially longer

I did some hours of a conversation with Gemini with google search, and here is the cleaned up, final draft of my research. still very vague, but good point to start. My initial curiosity revolved around whether the 5-MeO-DMT and MAOI combination could be safer than generally believed. If so, it might open avenues to explore prolonged states of nondual consciousness. However, there are clear cases resulting in death and severe serotonin toxicity. Despite research, it remains unclear why 5-MeO-DMT is dangerous with MAOIs while N,N-DMT is generally considered fine. I currently lack the resources and knowledge to conduct such experimentation, so I will not be pursuing this experiment anytime soon. Main Insights: 5-MeO-DMT combined with MAOIs can lead to blood concentrations 100-300 times higher than typical effective inhaled doses of 5-MeO-DMT. This suggests an experience potentially 100-300 times stronger than a high-dose "whiteout" smoked experience. Considering 5-MeO-DMT's 100-fold higher affinity for the 5-HT1A receptor compared to N,N-DMT, and the MAOI's effect on metabolism, the combined "signal" on this receptor could be ten thousands of times stronger than N,N-DMT's effect in ayahuasca so, 5-MeO-DMT with MAOI can be at least 100 times stronger than expected, upto 10000 times. (1mg -> 10g effect?) The Danger: 5-MeO-DMT + MAOI Mixing 5-MeO-DMT with MAOIs is dangerous. This combination often leads to Serotonin Toxicity, a severe condition. Symptoms of Serotonin Toxicity include: Anxiety Hypervigilance Rapid heart rate High blood pressure Elevated body temperature Excessive sweating Seizures Severe muscle rigidity Unlike the relatively short duration of smoked 5-MeO-DMT (around 20 minutes), the effects with MAOIs can last at least 4 hours, potentially causing the body to overheat severely. By default, this combination is hazardous. Medical supervision and safety backups (like "trip killers" and counter-actions to serotonin toxicity) are essential for any safe experimentation, if it were even possible. The 2005 Fatal Case: A Stark Example In 2005, a 25-year-old male died after ingesting 5-MeO-DMT and MAOIs. Post-mortem analysis revealed: Blood Concentration: 1.88 mg/L (or 1880 ng/mL) of 5-MeO-DMT in his heart blood. Stomach Content: 201 mg/L of 5-MeO-DMT. (Note: This doesn't mean he ingested 201 mg directly; it's a concentration in the stomach contents). To grasp the magnitude of exposure, compare the blood concentration found to typical effective doses: Fatal Blood Concentration: 1880 ng/mL. Typical Effective Inhaled 5-MeO-DMT (without MAOIs): 5-20 ng/mL for a profound, non-lethal experience. The 1880 ng/mL found in his blood is roughly 100-300 times higher than concentrations typically seen with effective inhaled doses. This suggests his experience was likely orders of magnitude more intense than a high-dose 5-MeO-DMT experience. While a precise ingested dose cannot be calculated, an estimated total amount in his body at death could be around 394 mg, though this is a vague assumption. Ayahuasca (N,N-DMT + MAOI): A Different Story The human body contains MAO-A enzymes, primarily in the gut, which break down both 5-MeO-DMT and N,N-DMT. Ayahuasca, by mixing MAOIs with N,N-DMT, aims to prolong the experience of DMT. However, the outcome is different: N,N-DMT Blood Concentration Comparison: Smoked/Vaporized N,N-DMT (without MAOI): Typical peak plasma concentrations (Cmax) range from 10 ng/mL to 80 ng/mL. Peaks are reached rapidly (minutes), then decline quickly (half-life 5-15 minutes). Oral N,N-DMT in Ayahuasca (with MAOI): Typical peak plasma concentrations (Cmax) for N,N-DMT in ayahuasca sessions generally fall within the range of 10 ng/mL to 100 ng/mL. Examples: ~33 ng/mL in one study, 12.14-17.44 ng/mL in another. The MAOI enables oral activity, leading to a slower onset and longer duration (4-6 hours), but the peak concentrations are often numerically similar to smoked DMT. For N,N-DMT, the MAOIs in ayahuasca primarily enable oral bioavailability and prolong the duration, rather than causing a drastic increase in peak blood concentration to toxic levels. This is why a 200-300 mg oral dose of N,N-DMT in ayahuasca might be considered a high but manageable dose, while a similar dose of 5-MeO-DMT with an MAOI is lethal. The Core Question: Why the Drastic Difference in Accumulation? This leads to the central question: Why was there significantly higher 5-MeO-DMT in the blood in the fatal case, despite both compounds being metabolized by MAO-A and both scenarios involving MAOI inhibition? The answer lies in inherent potency and receptor affinity: 5-MeO-DMT: The Focused "Spear" It has an at least 100-fold higher affinity (Ki: 1.9 nM) for the 5-HT1A receptor (linked to ego-dissolution) compared to N,N-DMT (Ki: 183 nM). This means 5-MeO-DMT is incredibly efficient at activating this specific receptor. A tiny amount can produce a profound effect. When its breakdown is blocked by an MAOI, this highly potent compound accumulates rapidly to overwhelming, toxic levels. N,N-DMT: The "All-Rounder" N,N-DMT is less selective, acting on 5-HT1A, 5-HT2A (responsible for visuals), and many other receptors. While MAOIs enable its oral activity, its lower inherent potency means that even with inhibited breakdown, the peak concentrations reached are generally within a range that produces intense psychedelic effects without immediate systemic toxicity. Two main hypotheses emerge for the extreme 5-MeO-DMT accumulation: Synergistic Overload: The combination of 5-MeO-DMT's 100-fold stronger affinity for 5-HT1A and a significantly reduced metabolization speed due to MAOI means the "signal" from 5-MeO-DMT is hitting the 5-HT1A "button" ten thousands of times more strongly and frequently. This leads to a rapid and severe overstimulation of the serotonin system. Accidental Overdose: It's possible the individual simply ingested an extremely high dose of 5-MeO-DMT, perhaps mistaking its potency for that of N,N-DMT, leading to a massive overdose that even partial MAO inhibition turned lethal. Conclusion: Disciplinary experimentation and rigorous execution are still needed to fully understand if a safe way to combine 5-MeO-DMT with MAOIs exists. Even if theoretically possible, the extreme potency of 5-MeO-DMT and the narrow margin for error mean that miscalculation or confusion could easily lead to death. Safety backups, medical supervision, and immediate counter-actions for serotonin toxicity would be absolutely critical for any such endeavor. By default, mixing 5-MeO-DMT and MAOIs remains highly hazardous.