serotonin, dopaamine and psychedelics

[mark patrick]

Hello Leo and All,  Many years ago I did some 600 trips in two and a half years ( i kept a diary, and so did a friend). I had many remarkable insights, and recognize many of the states you discuss. After watching your latest retreat (may 2018), I just had to write and say that, in my experience, what you were discussing in terms of suicidal thoughts and meaninglessness could be accounted for by a leaching of serotonin or dopamine through the use of psychedelics. Has anyone had any similar experiences?  does anyone know how to bolster the neurochemical resistance to this leaching of these neurotransmitters to prevent negative fallout from this? I raise this as it is something that certainly needs considering if you are taking a shamanic path that uses repeated heavy doses of psychoactives.

yours with blessings, Mark Patrick.