5-MeO basically has no tolerance so you could do back to back doses. The real issue is whether you'd actually want to redose. 10mg is a good starting dose for snorting/plugging. 5mg is too little unless you are smoking it. 10mg snorted will freak you out enough that you probably won't want to redose that day. Even 10mg if its your first time can be very shocking. For me 5-MeO trips tend to be so deep that I would never want to redose same day. I would plan it like this: Day 1: 10-12mg Day 2: 15-20mg Day 3: 25mg A week later: 30mg Even that will be emotionally challenging to pull off. After my 30mg dose I didn't want to do 5-MeO for a whole year. That's how strong it is. I still have no desire to do a 30mg dose. At 30mg your life as a human being is over.