Hey fellow actualizers, I would like to share with you my story with 5-MeO-DMT. 
I made a post previously talking about my experience with low dosages. In this post, I will describe the full encounter. Getting the substance
I got this substance semi-legally about a month ago. I got it from a legal research chemical distributor. They will sell it to you provided you don't have the intention of using it on yourself or others. DMT is a scheduled 3 substance in Canada, which is not that high priority (Cannabis was scheduled 2 up until recently). Also, 5-MeO is not very known from the DMT family. RoA
I've experimented with both snorting and plugging. Initially, I started with snorting, but I discovered that it wasn't the most effective for me. I didn't like the burning in my nose, I was losing substance, my nose became very dry, and I would have some dry blood in my nose afterward. Plugging, on the other hand, was very clean. The substance dissolves in water and you are able to absorb it much easier and faster with rectal administration. It is my opinion that plugging is the way to go (provided you get a small syringe  ).
  Small Dose
I've already made a lengthy post about my experiences on a small dose. To summarize it, at first, I felt a slight discomfort with tension in my head, small buzz, a little bit of shivering and nausea. These were minuscule and not very noticeable. Afterward came a very deep meditative state. This was meditation and contemplation on steroids. As if I took my most contemplative moments and multiplied them by 1000. My mind was firing with cognitive activity all over. Thoughts were cycling. Not just thoughts but more like "Aha" moments, like understanding after understanding and so on.  Insights were everywhere and all sensation became very potent. I've experienced moments of deep love and connection, omnipresence, insights about awareness and the present moment. After those peeks I came to a state of bliss and peacefulness. Overall it was great, the experiences went by after about 30 min I was back to baseline. I was still present as my Ego throughout the experiences. Insight:
Experience is the key. There is a whole world out there far beyond what mind can image and what we can put into words. Thinking/Language/Communication is also a type of experience, but only one out of an infinite sea of experiences and perceptions - don't give it too much weight.   Medium Dose
This trip was very very very different - 540 degrees different. I still can't fathom how you can get such a different experience from the same substance. This time it was very physical and can be summarized as hell, torture and slow death. All those discomforts that normally come up before the peak. Well, they got amplified to an unbearable degree. I felt an extreme amount of body discomfort. I wanted to escape to run away, to surrender. It wasn't a pain in a sense of somebody is cutting you with a knife. It wasn't fear either, as you can imagine standing on the edge of a building. It was this nasty nasty feeling of internal discomfort. Like when you're super anxious about something. Maybe loosely like when you wear an uncomfortable t-shirt, or its too hot, or something bothers and you want to jump out of your skin. You feel frustrated/angry/anxious at the same moment. It was a type of Ego-discomfort taken to the extreme of what's possible. I felt nauseous and wanted to puke very badly. My body was shaking like crazy. Not shaking from cold, but shaking from like a wound in a stomach. I felt like dying, like I couldn't take it anymore. I was trying to surrender to it, but I couldn't. I was trying to meta surrender - surrender to the fact that I couldn't surrender, but that didn't work either. I was fucked. Honestly, if you think you're a tough guy? I dare you to go through this.  Some of the thoughts going through my head:
"Why would you do this to yourself?" "Did I just overdosed and killed myself?" "I want this to pass!" "It's just a feeling, its just a feeling"
That was pretty much the whole experience. It lasted for about 30 min but man, it felt like an eternity! I was still present as my Ego throughout the experience though. Insight:
This is what dying is like. Ego is everything about you. It's a very physical thing! emotions and thoughts are interlinked. Subconscious thoughts give rise to emotions which give rise to surface thoughts and provoke actions. I heard before that Ego is just a thought, but dammit it goes so deep. It controls everything about our body. It is our whole existence. It is very subtle until your survival is threatened. 
I have huge respect for people who took 5-MeO-DMT   Heavy Dose Preface
Well needless to say that my previous trip freaked the shit out of me. I knew I came close, but not close enough to fall into the abyss. So I was musting up the courage. I knew that to go all the way I needed to die. My mind was coming up with excuses of not doing it. Suddenly things I was forcing myself to do became not so difficult just to avoid this experience (nice try mind).   From the previous trip, I knew that dying feels very real at that moment. There is no difference between that and "actual" death. It's funny but to actually make passing over easier, I wrote a final letter/suicide note to my loved ones. I typed it up, printed it and left it on my desk before the trip. This might sound too extreme, and I didn't think I was actually going to die. I thought I will come out of it, and the whole thing will look silly. But then again, at the back of my mind, I thought that you never know. Plus I would want somebody to leave me a comforting letter before they go. I got ready, did an hour of meditation, which put me in a very relaxing state. Experience
This substance keeps surprising me. It was very unexpected. I can't put it into words. It's just too much. The transition from regular consciousness was super clean. When the discomfort started to show up. I just laid on the bed, closed my eye and it passed away (or my sense of self passed away). I think the preparation and my state of surrender really helped. Either way, what happened cannot be even close to thoughts or words. It was deeper than time, space, ideas or my own self. I was the raw reality itself, it was impossible. It was there, but nobody was looking at it. Perceptions were there but nobody was there to perceive it. It's a f*cking paradox. You would think perceptions need a perceiver.  My body was extremely loose. It collapsed and I was far far far gone. The body was doing things by itself. I didn't even know if I was breathing. Some sensations were there, but it was sort of neutral. I can't even say neutral because that's putting it inside criteria. Really language is incapable of describing this. Words are kind of like post signs to experience. But it wasn't even an experience, because there was nobody to experience it.
It was incredible. But even to say that is giving it a judgment. It wasn't good or bad. It transcended all limits and criteria because there was nobody there to give any human judgment. Kind of like Earth was prior to humans.  My body could die or live it didn't matter. It was waaaaaayyy beyond my existence. The mind would occasionally talk, but it appeared sort of in the background like an echo. All It could say was - thing, no thing. It went on like this "existence, no existence" "love, no love" "life, no life" "enlightenment, no enlightenment" and so on about everything. There was no difference between anything. I was not present as my Ego throughout the experiences. I lied on my bed for 2 hours after this experience in a state of no-self. I could say that it was bliss. But even that is not true, because bliss implies an opposite to be true as a reference. There was no reference in this experience. Then there was a feeling in my belly. I could label it as me getting hungry, but there was no reason to act on it. No reason to act on anything for that matter. Eventually, the intensity was slowly coming down and I convinced myself to get up.  Insight: 
What I was describing is only what the mind can come up with. What actually happened transcended all of that. What happened is what is left when everything goes out the window. Every identification crumbled.  There is only this something - It is nothing, everything, energy, dark matter, empty space, Tao, awareness, God, aliens, simulation whatever you say about it. It is so much bigger than you, you are not even on its radar. There is no free will, nor somebody to not have free will. As an Ego, I am a puppet empty inside. When I die ... I will go back to the source.